Publication Date:
1983-06-17
Description:
In the house mouse (Mus musculus), fetuses may develop in utero next to siblings of the same or opposite sex. The amniotic fluid of the female fetuses contains higher concentrations of estradiol than that of male fetuses. Male fetuses that developed in utero between female fetuses had higher concentrations of estradiol in their amniotic fluid than males that were located between other male fetuses during intrauterine development. They were also more sexually active as adults, less aggressive, and had smaller seminal vesicles than males that had developed between other male fetuses in utero. These findings raise the possibility that during fetal life circulating estrogens may interact with circulating androgens both in regulating the development of sex differences between males and females and in producing variation in phenotype among males and among females.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉vom Saal, F S -- Grant, W M -- McMullen, C W -- Laves, K S -- MH35079/MH/NIMH NIH HHS/ -- RR07053/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1983 Jun 17;220(4603):1306-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857252" target="_blank"〉PubMed〈/a〉
Keywords:
Aggression/*drug effects
;
Amniotic Fluid/analysis
;
Animals
;
Estradiol/analysis/*pharmacology/physiology
;
Female
;
Fetus/*drug effects/physiology
;
Humans
;
Male
;
Mice
;
Progesterone/pharmacology
;
Rats
;
Rats, Inbred Strains
;
Sex Differentiation/drug effects
;
Sexual Behavior, Animal/*drug effects/physiology
;
Testosterone/analysis/pharmacology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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