Publication Date:
2000-12-02
Description:
Bone marrow stem cells give rise to a variety of hematopoietic lineages and repopulate the blood throughout adult life. We show that, in a strain of mice incapable of developing cells of the myeloid and lymphoid lineages, transplanted adult bone marrow cells migrated into the brain and differentiated into cells that expressed neuron-specific antigens. These findings raise the possibility that bone marrow-derived cells may provide an alternative source of neurons in patients with neurodegenerative diseases or central nervous system injury.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mezey, E -- Chandross, K J -- Harta, G -- Maki, R A -- McKercher, S R -- AI30656/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2000 Dec 1;290(5497):1779-82.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Basic Neuroscience Program, Laboratory of Developmental Neurogenetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. mezey@codon.nih.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11099419" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigens/analysis
;
Biomarkers/analysis
;
Bone Marrow Cells/*cytology/physiology
;
*Bone Marrow Transplantation
;
Brain/*cytology
;
Cell Differentiation
;
Cell Movement
;
Female
;
Immunoenzyme Techniques
;
Intermediate Filament Proteins/analysis
;
Male
;
Mice
;
Mice, Knockout
;
Microscopy, Confocal
;
Nerve Tissue Proteins/analysis/immunology
;
Nestin
;
Neurons/chemistry/*cytology/immunology
;
Phosphopyruvate Hydratase/analysis
;
*Stem Cell Transplantation
;
Stem Cells/chemistry/*cytology
;
Y Chromosome
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
