ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
Collection
Keywords
Publisher
Language
Years
  • 1
    Monograph available for loan
    Monograph available for loan
    Glaciated margins : the sedimentary and geophysical archive (2019)
    London : The Geological Society
    Associated volumes
    Details Availability
    Call number: 9/M 07.0421(475)
    In: Geological Society Special Publication
    Description / Table of Contents: Abstract Understanding the sedimentary and geophysical archive of glaciated margins is a complex task that requires integration and analysis of disparate sedimentological and geophysical data. Their analysis is vital for understanding the dynamics of past ice sheets and how they interact with their neighbouring marine basins, on timescales that cannot be captured by observations of the cryosphere today. As resources, sediments deposited on the inner margins of glaciated shelves also exhibit resource potential where more sand-dominated systems occur, acting as reservoirs for both hydrocarbons and water. This book surveys the full gamut of glaciated margins, from deep time (Neoproterozoic, Ordovician and Carboniferous–Permian) to modern high-latitude margins in Canada and Antarctica. This collection of papers is the first attempt to deliberately do this, allowing not only the similarities and differences between modern and ancient glaciated margins to be explored, but also the wide spectrum of their mechanisms of investigation to be probed. Together, these papers offer a high-resolution, spatially and temporally diverse blueprint of the depositional processes, ice sheet dynamics, and basin architectures of the world's former glaciated margins; a vital resource in advancing understanding of our present and future marine-terminating ice sheet margins.
    Type of Medium: Monograph available for loan
    Pages: 288 Seiten , Illustrationen
    ISBN: 978-1-78620-397-7
    Series Statement: Geological Society Special Publication 475
    URL: https://sp.lyellcollection.org/content/475/1
    Language: English
    Location: Reading room
    Branch Library: GFZ Library
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    BOOK
    Link to Library Catalog
    get availability status
  • 2
    Unknown
    Glaciated Margins: The Sedimentary and Geophysical Archive (2019)
    London : The Geological Society
    Details
    Keywords: cryosphere ; glaciology ; sedimentology ; geophysics
    Description / Table of Contents: An introduction to glaciated margins: the sedimentary and geophysical archive / D. P. Le Heron, K. A. Hogan, E. R. Phillips, M. Huuse, M. E. Busfield and A. G. C. Graham / Geological Society, London, Special Publications, 475, 1-8, 30 January 2019, https://doi.org/10.1144/SP475.12 --- Glacio-marine iron formation deposition in a c. 700 Ma glaciated margin: insights from the Chuos Formation, Namibia / Maxwell A. Lechte, Malcolm W. Wallace and Karl-Heinz Hoffmann / Geological Society, London, Special Publications, 475, 9-34, 16 March 2018, https://doi.org/10.1144/SP475.2 --- A tale of two rift shoulders, and two ice masses: the Cryogenian glaciated margin of Death Valley, California / D. P. Le Heron, M. E. Busfield, D. O. Ali, T. Vandyk and S. Tofaif / Geological Society, London, Special Publications, 475, 35-52, 27 July 2018, https://doi.org/10.1144/SP475.11 --- Zarqa megafacies: widespread subglacial deformation in the Sarah Formation of Saudi Arabia and implications for the sequence stratigraphy of the Hirnantian glaciation / John Melvin / Geological Society, London, Special Publications, 475, 53-80, 7 March 2018, https://doi.org/10.1144/SP475.6 --- Development of a palaeovalley complex on a Late Ordovician glaciated margin in NW Saudi Arabia / S. Tofaif, D. P. Le Heron and J. Melvin / Geological Society, London, Special Publications, 475, 81-107, 6 June 2018, https://doi.org/10.1144/SP475.8 --- Depositional model for the distal Ordovician glaciated margin of Jordan; implications for the reservoir potential of the Risha Formation / J. Philip P. Hirst and Maher Khatatneh / Geological Society, London, Special Publications, 475, 109-129, 1 March 2018, https://doi.org/10.1144/SP475.4 --- Sedimentary record of Early Permian deglaciation in southern Gondwana from the Falkland Islands / Kate Horan, Philip Stone and Simon J. Crowhurst / Geological Society, London, Special Publications, 475, 131-147, 19 March 2018, https://doi.org/10.1144/SP475.1 --- Deglacial sequences and glacio-isostatic adjustment: Quaternary compared with Ordovician glaciations / Pierre Dietrich, Jean-François Ghienne, Patrick Lajeunesse, Alexandre Normandeau, Rémy Deschamps and Philippe Razin / Geological Society, London, Special Publications, 475, 149-179, 14 May 2018, https://doi.org/10.1144/SP475.9 --- Sedimentary processes and facies on a high-latitude passive continental margin, Wilkes Land, East Antarctica / Sandra Passchier, Daniel J. Ciarletta, Victor Henao and Vicky Sekkas / Geological Society, London, Special Publications, 475, 181-201, 16 March 2018, https://doi.org/10.1144/SP475.3 --- Processes influencing differences in Arctic and Antarctic trough mouth fan sedimentology / Jenny Gales, Claus-Dieter Hillenbrand, Rob Larter, Jan Sverre Laberg, Martin Melles, Sara Benetti and Sandra Passchier / Geological Society, London, Special Publications, 475, 203-221, 23 March 2018, https://doi.org/10.1144/SP475.7 --- Seismic and geomorphic records of Antarctic Ice Sheet evolution in the Ross Sea and controlling factors in its behaviour / John B. Anderson, Lauren M. Simkins, Phillip J. Bart, Laura De Santis, Anna Ruth W. Halberstadt, Elisabetta Olivo and Sarah L. Greenwood / Geological Society, London, Special Publications, 475, 223-240, 17 April 2018, https://doi.org/10.1144/SP475.5 --- Late Wisconsinan grounding zones of the Laurentide Ice Sheet margin off the Québec North Shore (NW Gulf of St Lawrence) / P. Lajeunesse, P. Dietrich and J.-F. Ghienne / Geological Society, London, Special Publications, 475, 241-259, 25 June 2018, https://doi.org/10.1144/SP475.10 --- The glacier-influenced marine record on high-latitude continental margins: synergies between modern, Quaternary and ancient evidence / J. A. Dowdeswell, K. A. Hogan and D. P. Le Heron / Geological Society, London, Special Publications, 475, 261-279, 29 January 2019, https://doi.org/10.1144/SP475.13
    Pages: Online-Ressource (288 Seiten) , Illustrationen, Diagramme, Karten
    ISBN: 9781786203977
    URL: https://sp.lyellcollection.org/content/475/1
    Language: English
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOK
  • 3
    facet.materialart.
    Unknown
    Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases (2015)
    American Chemical Society (ACS)
    Details
    Publication Date: 2015-09-11
    Description: Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.5b00301
    Topics: Chemistry and Pharmacology
    Published by American Chemical Society (ACS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 4
    facet.materialart.
    Unknown
    Author Correction: Trans-differentiation of outer hair cells into inner hair cells in the absence of INSM1 (2018)
    Springer Nature
    In: Nature
    Details
    Publication Date: 2018
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Springer Nature
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 5
    facet.materialart.
    Unknown
    The Integration of Data Review, Remote Sensing and Ground Survey for a Regional-Level Karst Assessment (2016)
    Association of Engineering Geologists (AEG)
    Details
    Publication Date: 2016-03-04
    Description: Detailed karst terrain assessments require the identification and survey of surface features such as closed depressions, sinkholes, and cave entrances. Typically, surveys are carried out at sites encompassing several hundred acres or less; however, the traditional methods have proven impractical from a time and expense viewpoint for extensive, regional-level surveys in well-developed karst terrain. This subject survey covered a 76-mi (122.3-km) length of a natural gas transmission pipeline. The goal of the study was to assist the United States Fish and Wildlife Service in assessing habitat vulnerability for the Madison Cave Isopod, a federally protected threatened species found only in phreatic ground water of the Great Valley of Virginia and West Virginia. The survey used an integrated approach involving the evaluation of topographic maps, digital elevation models, shaded relief maps, satellite imagery, and historic aerial photographs to identify "concentrations" of karst features. Ground surveys were then undertaken by walking sections of the pipeline right-of-ways that occurred within karst concentrations, and documenting the features using GPS instrumentation. The karst survey encompassed 48,640 acres (19.2 hectares), and was the largest utility-associated karst assessment ever conducted in the Commonwealth of Virginia. Approximately 216 closed depressions and 28 cave entrances were located, identified, and described based on their geology, physical appearance, and drainage characteristics. The use of an integrated approach significantly reduced the time and cost of the study. The study’s findings and recommendations have been used to develop conservation-based avoidance and minimization measures intended to limit the impact to the species’ habitat.
    Print ISSN: 1078-7275
    Topics: Geosciences
    Published by Association of Engineering Geologists (AEG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 6
    facet.materialart.
    Unknown
    Ultraviolet radiation accelerates BRAF-driven melanomagenesis by targeting TP53 (2014)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2014-06-12
    Description: Cutaneous melanoma is epidemiologically linked to ultraviolet radiation (UVR), but the molecular mechanisms by which UVR drives melanomagenesis remain unclear. The most common somatic mutation in melanoma is a V600E substitution in BRAF, which is an early event. To investigate how UVR accelerates oncogenic BRAF-driven melanomagenesis, we used a BRAF(V600E) mouse model. In mice expressing BRAF(V600E) in their melanocytes, a single dose of UVR that mimicked mild sunburn in humans induced clonal expansion of the melanocytes, and repeated doses of UVR increased melanoma burden. Here we show that sunscreen (UVA superior, UVB sun protection factor (SPF) 50) delayed the onset of UVR-driven melanoma, but only provided partial protection. The UVR-exposed tumours showed increased numbers of single nucleotide variants and we observed mutations (H39Y, S124F, R245C, R270C, C272G) in the Trp53 tumour suppressor in approximately 40% of cases. TP53 is an accepted UVR target in human non-melanoma skin cancer, but is not thought to have a major role in melanoma. However, we show that, in mice, mutant Trp53 accelerated BRAF(V600E)-driven melanomagenesis, and that TP53 mutations are linked to evidence of UVR-induced DNA damage in human melanoma. Thus, we provide mechanistic insight into epidemiological data linking UVR to acquired naevi in humans. Furthermore, we identify TP53/Trp53 as a UVR-target gene that cooperates with BRAF(V600E) to induce melanoma, providing molecular insight into how UVR accelerates melanomagenesis. Our study validates public health campaigns that promote sunscreen protection for individuals at risk of melanoma.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112218/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112218/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Viros, Amaya -- Sanchez-Laorden, Berta -- Pedersen, Malin -- Furney, Simon J -- Rae, Joel -- Hogan, Kate -- Ejiama, Sarah -- Girotti, Maria Romina -- Cook, Martin -- Dhomen, Nathalie -- Marais, Richard -- A12738/Cancer Research UK/United Kingdom -- A13540/Cancer Research UK/United Kingdom -- A17240/Cancer Research UK/United Kingdom -- A7091/Cancer Research UK/United Kingdom -- A7192/Cancer Research UK/United Kingdom -- C107/A10433/Cancer Research UK/United Kingdom -- C5759/A12328/Cancer Research UK/United Kingdom -- England -- Nature. 2014 Jul 24;511(7510):478-82. doi: 10.1038/nature13298. Epub 2014 Jun 11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK [2]. ; 1] Signal Transduction Team, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK [2]. ; Signal Transduction Team, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK. ; Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK. ; 1] Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK [2] Histopathology, Royal Surrey County Hospital, Egerton Road, Guildford GU2 7XX, UK. ; 1] Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK [2] Signal Transduction Team, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24919155" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Cell Transformation, Neoplastic/*genetics/*radiation effects ; DNA Damage/genetics ; Disease Models, Animal ; Female ; Humans ; Melanocytes/metabolism/pathology/radiation effects ; Melanoma/etiology/*genetics/metabolism/*pathology ; Mice ; Mice, Inbred C57BL ; Mutagenesis/genetics/*radiation effects ; Mutation/genetics/radiation effects ; Nevus/etiology/genetics/metabolism/pathology ; Proto-Oncogene Proteins B-raf/*genetics/metabolism ; Skin Neoplasms/etiology/genetics/metabolism/pathology ; Sunburn/complications/etiology/genetics ; Sunscreening Agents/pharmacology ; Tumor Suppressor Protein p53/*genetics/metabolism ; Ultraviolet Rays/*adverse effects
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 7
    facet.materialart.
    Unknown
    Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-05-09
    Description: Limited evidence exists that humans mount a mutation-specific T cell response to epithelial cancers. We used a whole-exomic-sequencing-based approach to demonstrate that tumor-infiltrating lymphocytes (TIL) from a patient with metastatic cholangiocarcinoma contained CD4+ T helper 1 (T(H)1) cells recognizing a mutation in erbb2 interacting protein (ERBB2IP) expressed by the cancer. After adoptive transfer of TIL containing about 25% mutation-specific polyfunctional T(H)1 cells, the patient achieved a decrease in target lesions with prolonged stabilization of disease. Upon disease progression, the patient was retreated with a 〉95% pure population of mutation-reactive T(H)1 cells and again experienced tumor regression. These results provide evidence that a CD4+ T cell response against a mutated antigen can be harnessed to mediate regression of a metastatic epithelial cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tran, Eric -- Turcotte, Simon -- Gros, Alena -- Robbins, Paul F -- Lu, Yong-Chen -- Dudley, Mark E -- Wunderlich, John R -- Somerville, Robert P -- Hogan, Katherine -- Hinrichs, Christian S -- Parkhurst, Maria R -- Yang, James C -- Rosenberg, Steven A -- Intramural NIH HHS/ -- New York, N.Y. -- Science. 2014 May 9;344(6184):641-5. doi: 10.1126/science.1251102.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Surgery Branch, National Cancer Institute (NCI), National Institutes of Health, Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24812403" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptor Proteins, Signal Transducing/*genetics ; Adoptive Transfer/*methods ; Adult ; Bile Duct Neoplasms/genetics/*therapy ; *Bile Ducts, Intrahepatic ; CD4-Positive T-Lymphocytes/*immunology ; Cholangiocarcinoma/genetics/*therapy ; Clinical Trials, Phase II as Topic ; Exome ; Female ; Humans ; Lymphocytes, Tumor-Infiltrating/*transplantation ; Mutation ; Receptor, ErbB-2/metabolism ; Th1 Cells/*transplantation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 8
    facet.materialart.
    Unknown
    BedMachine v3: Complete bed topography and ocean bathymetry mapping of Greenland from multi-beam echo sounding combined with mass conservation (2017)
    Wiley
    Details
    Publication Date: 2017-09-19
    Description: Greenland's bed topography is a primary control on ice flow, grounding line migration, calving dynamics and subglacial drainage. Moreover, fjord bathymetry regulates the penetration of warm Atlantic Water (AW) that rapidly melts and undercuts Greenland's marine-terminating glaciers. Here, we present a new compilation of Greenland bed topography that assimilates seafloor bathymetry and ice thickness data through a mass conservation (MC) approach. A new 150-m horizontal resolution bed topography/bathymetric map of Greenland is constructed with seamless transitions at the ice/ocean interface, yielding major improvements over previous datasets, particularly in the marine-terminating sectors of northwest and southeast Greenland. Our map reveals the total sea level potential of the Greenland Ice Sheet is 7.42±0.05 m, which is 7 cm greater than previous estimates. Furthermore, it explains recent calving front response of numerous outlet glaciers and reveals new pathways by which AW can access glaciers with marine-based basins, thereby highlighting sectors of Greenland that are most vulnerable to future oceanic forcing.
    Print ISSN: 0094-8276
    Electronic ISSN: 1944-8007
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 9
    facet.materialart.
    Unknown
    Insect Wing Membrane Topography Is Determined by the Dorsal Wing Epithelium (2013)
    Genetics Society of America (GSA)
    Details
    Publication Date: 2013-01-11
    Description: The Drosophila wing consists of a transparent wing membrane supported by a network of wing veins. Previously, we have shown that the wing membrane cuticle is not flat but is organized into ridges that are the equivalent of one wing epithelial cell in width and multiple cells in length. These cuticle ridges have an anteroposterior orientation in the anterior wing and a proximodistal orientation in the posterior wing. The precise topography of the wing membrane is remarkable because it is a fusion of two independent cuticle contributions from the dorsal and ventral wing epithelia. Here, through morphological and genetic studies, we show that it is the dorsal wing epithelium that determines wing membrane topography. Specifically, we find that wing hair location and membrane topography are coordinated on the dorsal, but not ventral, surface of the wing. In addition, we find that altering Frizzled Planar Cell Polarity ( i.e. , Fz PCP) signaling in the dorsal wing epithelium alone changes the membrane topography of both dorsal and ventral wing surfaces. We also examined the wing morphology of two model Hymenopterans, the honeybee Apis mellifera and the parasitic wasp Nasonia vitripennis . In both cases, wing hair location and wing membrane topography are coordinated on the dorsal, but not ventral, wing surface, suggesting that the dorsal wing epithelium also controls wing topography in these species. Because phylogenomic studies have identified the Hymenotera as basal within the Endopterygota family tree, these findings suggest that this is a primitive insect character.
    Electronic ISSN: 2160-1836
    Topics: Biology
    Published by Genetics Society of America (GSA)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 10
    facet.materialart.
    Unknown
    Landform assemblage produced by ice-grounding events on the Yermak Plateau (2016)
    Geological Society
    In:  EPIC3Atlas of Submarine Glacial Landforms: Modern, Quaternary and Ancient., Geological Society, London, Memoirs, London, Memoirs, Geological Society, 46(1), pp. 329-332, ISSN: 0435-4052
    Details
    Publication Date: 2017-06-01
    Description: The landforms and sediments preserved on the Yermak Plateau (Figs 1–3) provide information on the glacial history and past dynamics of the northwestern-most sector of the Eurasian Ice Sheet (Dowdeswell et al. 2010; Gebhardt et al. 2011), as well as the exchange of ice and water between the North Atlantic and the Arctic Ocean via Fram Strait (Fig. 1a) (Jakobsson et al. 2010). Early ideas about Quaternary ice cover in the Arctic Ocean pro- posed the existence of a circum-Arctic ice shelf prior to the last gla- ciation (e.g. Mercer 1970). More recent work suggested that the major glaciations since the interglacial period of marine oxygen isotope stage (MIS) 5.5 did not extend beyond the Eurasian conti- nental shelf edges. However, geophysical data reveal that ice extended across the Yermak Plateau prior to MIS 5.5 during the particularly extensive glaciation in MIS 6 (Dowdeswell et al. 2010; Jakobsson et al. 2010). By contrast, the presence of a grounding-zone complex beyond NW Spitsbergen (Fig. 3) implies that grounded ice did not extend onto the Yermak Plateau during the Last Glacial Maximum (LGM) (Ottesen & Dowdeswell 2009).
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , peerRev
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...