Publication Date:
2016-04-16
Description:
Immune-mediated tissue regeneration driven by a biomaterial scaffold is emerging as an innovative regenerative strategy to repair damaged tissues. We investigated how biomaterial scaffolds shape the immune microenvironment in traumatic muscle wounds to improve tissue regeneration. The scaffolds induced a pro-regenerative response, characterized by an mTOR/Rictor-dependent T helper 2 pathway that guides interleukin-4-dependent macrophage polarization, which is critical for functional muscle recovery. Manipulating the adaptive immune system using biomaterials engineering may support the development of therapies that promote both systemic and local pro-regenerative immune responses, ultimately stimulating tissue repair.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866509/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866509/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sadtler, Kaitlyn -- Estrellas, Kenneth -- Allen, Brian W -- Wolf, Matthew T -- Fan, Hongni -- Tam, Ada J -- Patel, Chirag H -- Luber, Brandon S -- Wang, Hao -- Wagner, Kathryn R -- Powell, Jonathan D -- Housseau, Franck -- Pardoll, Drew M -- Elisseeff, Jennifer H -- P30 CA006973/CA/NCI NIH HHS/ -- P30CA006973/CA/NCI NIH HHS/ -- R01AI077610/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2016 Apr 15;352(6283):366-70. doi: 10.1126/science.aad9272.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Translational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21287, USA. Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA. ; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA. Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA. ; Division of Biostatistics and Bioinformatics, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA. Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA. ; Hugo W. Moser Research Institute at Kennedy Krieger Institute, Baltimore, MD 21205, USA, and Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27081073" target="_blank"〉PubMed〈/a〉
Keywords:
Adaptive Immunity
;
Animals
;
*Biocompatible Materials
;
Carrier Proteins/genetics/metabolism
;
Disease Models, Animal
;
Homeostasis/immunology
;
Interleukin-4/genetics/immunology
;
Macrophages/immunology
;
Mice, Inbred C57BL
;
Muscle, Skeletal/*injuries/*physiology
;
TOR Serine-Threonine Kinases/genetics/metabolism
;
Th2 Cells/immunology
;
Tissue Engineering
;
*Tissue Scaffolds
;
Wound Healing/*immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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