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  • 1
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    Animal model for EV71 pathogenesis [Microbiology] (2013)
    National Academy of Sciences
    Details
    Publication Date: 2013-09-04
    Description: Enterovirus 71 (EV71) typically causes mild hand-foot-and-mouth disease in children, but it can also cause severe neurological disease. Recently, epidemic outbreaks of EV71 with significant mortality have been reported in the Asia-Pacific region, and EV71 infection has become a serious public health concern worldwide. However, there is little information available...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 2
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    Clustering of foreshocks and preshocks in the circum-Aegean region (1985)
    In:  Earthq. Pred. Res., Köln, Elsevier, vol. 3, no. 5, pp. 121-140, pp. 1015, (ISSN: 1340-4202)
    Details
    Publication Date: 1985
    Keywords: Seismicity ; Earthquake precursor: statistical anal. of seismicity ; Fore-shocks ; Earthquake precursor: prediction research
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    BIBLIOGRAPHY SEISMOLOGY
  • 3
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    The computation of reference state and APE production by diabatic processes in an idealised tropical cyclone (2016)
    Wiley
    Details
    Publication Date: 2016-06-17
    Description: This study investigates the energetics of tropical cyclone intensification using the Available Potential Energy (APE) theory. While the idea that tropical cyclones (TCs) intensify as the result of the conversion into kinetic energy of the available potential energy (APE) generated by the release of latent heat extracted from the warm tropical ocean surface is now well accepted, its rigorous theoretical formalisation has remained elusive owing to the complexity of constructing a suitable reference state for defining and quantifying APE in a moist atmosphere. Yet, the construction of such a reference state is a key fundamental issue, because the magnitude of the APE reservoir and of its temporal evolution, as well as the values of the thermodynamic efficiencies controlling the rate at which diabatic processes generate or destroy APE, depend on its specification. This issue is illustrated in the idealised context of an axisymmetric TC model by comparing the energetics of TC intensification obtained by using two different sorting-based approaches to compute the reference state defining APE. It is found that the thermodynamic efficiency controlling the APE generation by surface latent heat fluxes is larger when the reference state is constructed using a ‘top-down’ sorting method, as the APE thus defined absorbs all the CAPE present in the system. However, because a large fraction of the overall CAPE is never released during the TC’s lifetime (e.g. in regions dominated by subsidence), there is a better agreement between the production of APE by surface fluxes and its subsequent conversion into kinetic energy when a ‘bottom-up’ reference state is used. These results suggest that contrary to what is usually assumed, the reference state in APE theory should be constructed to minimise , rather than maximise, the total APE, so that the introduction of dynamically inert APE is minimised.
    Print ISSN: 0035-9009
    Electronic ISSN: 1477-870X
    Topics: Geography , Physics
    Published by Wiley
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  • 4
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    Weyl fluid dark matter model tested on the galactic scale by weak gravitational lensing (2012)
    American Physical Society (APS)
    Details
    Publication Date: 2012-08-24
    Description: Author(s): K. C. Wong, T. Harko, K. S. Cheng, and L. Á. Gergely The higher-dimensional Weyl curvature induces on the brane a new source of gravity. This Weyl fluid of geometrical origin (reducing in the spherically symmetric, static configuration to a dark radiation and dark pressure) modifies spacetime geometry around galaxies and has been shown to explain the ... [Phys. Rev. D 86, 044038] Published Thu Aug 23, 2012
    Keywords: General relativity, gravitation
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
    Published by American Physical Society (APS)
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  • 5
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    Strain Effects on the Crystal Growth and Superconducting Properties of Epitaxial Niobium Ultrathin Films (2012)
    American Chemical Society (ACS)
    Details
    Publication Date: 2012-03-31
    Description: Crystal Growth & Design DOI: 10.1021/cg3001834
    Print ISSN: 1528-7483
    Electronic ISSN: 1528-7505
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Published by American Chemical Society (ACS)
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  • 6
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    Mirsynergy: detecting synergistic miRNA regulatory modules by overlapping neighbourhood expansion (2014)
    Oxford University Press
    Details
    Publication Date: 2014-09-06
    Description: Motivation: Identification of microRNA regulatory modules (MiRMs) will aid deciphering aberrant transcriptional regulatory network in cancer but is computationally challenging. Existing methods are stochastic or require a fixed number of regulatory modules. Results: We propose Mirsynergy, an efficient deterministic overlapping clustering algorithm adapted from a recently developed framework. Mirsynergy operates in two stages: it first forms MiRMs based on co-occurring microRNA (miRNA) targets and then expands each MiRM by greedily including (excluding) mRNAs into (from) the MiRM to maximize the synergy score, which is a function of miRNA–mRNA and gene–gene interactions. Using expression data for ovarian, breast and thyroid cancer from The Cancer Genome Atlas, we compared Mirsynergy with internal controls and existing methods. Mirsynergy-MiRMs exhibit significantly higher functional enrichment and more coherent miRNA–mRNA expression anti-correlation. Based on Kaplan–Meier survival analysis, we proposed several prognostically promising MiRMs and envisioned their utility in cancer research. Availability and implementation: Mirsynergy is implemented/available as an R/Bioconductor package at www.cs.utoronto.ca/~yueli/Mirsynergy.html Contact: yueli@cs.toronto.edu ; zhaolei.zhang@utoronto.ca Supplementary information: Supplementary data are available at Bioinformatics online.
    Print ISSN: 1367-4803
    Electronic ISSN: 1460-2059
    Topics: Biology , Computer Science , Medicine
    Published by Oxford University Press
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  • 7
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    An epigenome-wide association study of total serum immunoglobulin E concentration (2015)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2015-02-25
    Description: Immunoglobulin E (IgE) is a central mediator of allergic (atopic) inflammation. Therapies directed against IgE can alleviate hay fever and allergic asthma. Genetic association studies have not yet identified novel therapeutic targets or pathways underlying IgE regulation. We therefore surveyed epigenetic associations between serum IgE concentrations and methylation at loci concentrated in CpG islands genome wide in 95 nuclear pedigrees, using DNA from peripheral blood leukocytes. We validated positive results in additional families and in subjects from the general population. Here we show replicated associations--with a meta-analysis false discovery rate less than 10(-4)--between IgE and low methylation at 36 loci. Genes annotated to these loci encode known eosinophil products, and also implicate phospholipid inflammatory mediators, specific transcription factors and mitochondrial proteins. We confirmed that methylation at these loci differed significantly in isolated eosinophils from subjects with and without asthma and high IgE levels. The top three loci accounted for 13% of IgE variation in the primary subject panel, explaining the tenfold higher variance found compared with that derived from large single-nucleotide polymorphism genome-wide association studies. This study identifies novel therapeutic targets and biomarkers for patient stratification for allergic diseases.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416961/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416961/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Liang, Liming -- Willis-Owen, Saffron A G -- Laprise, Catherine -- Wong, Kenny C C -- Davies, Gwyneth A -- Hudson, Thomas J -- Binia, Aristea -- Hopkin, Julian M -- Yang, Ivana V -- Grundberg, Elin -- Busche, Stephan -- Hudson, Marie -- Ronnblom, Lars -- Pastinen, Tomi M -- Schwartz, David A -- Lathrop, G Mark -- Moffatt, Miriam F -- Cookson, William O C M -- 096964/Wellcome Trust/United Kingdom -- 097117/Wellcome Trust/United Kingdom -- P01-ES18181/ES/NIEHS NIH HHS/ -- R01 HL101251-01/HL/NHLBI NIH HHS/ -- WT 077959/Wellcome Trust/United Kingdom -- WT096964/Wellcome Trust/United Kingdom -- Medical Research Council/United Kingdom -- England -- Nature. 2015 Apr 30;520(7549):670-4. doi: 10.1038/nature14125. Epub 2015 Feb 18.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departments of Epidemiology and Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA. ; National Heart and Lung Institute, Imperial College, London SW3 6LY, UK. ; Universite du Quebec a Chicoutimi, Saguenay, Quebec G7H 2B1, Canada. ; Institute of Life Science, College of Medicine, Swansea University, Swansea SA2 8PP, UK. ; 1] Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada [2] Departments of Medical Biophysics and Molecular Genetics, University of Toronto, Ontario M5S 1A1, Canada. ; University of Colorado School of Medicine and National Jewish Health, Denver, Colorado 80206, USA. ; Department of Human Genetics, McGill University and Genome Quebec Innovation Centre, Montreal H3A 1B1, Canada. ; Jewish General Hospital and Lady Davis Research Institute, Montreal H3T 1E2, Canada. ; Department of Medical Sciences, SciLifeLab, Uppsala University, Uppsala SE-751 44, Sweden. ; 1] Department of Human Genetics, McGill University and Genome Quebec Innovation Centre, Montreal H3A 1B1, Canada [2] Department of Medical Genetics, McGill University Health Centre, Montreal H3H 1P3, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25707804" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Asthma/blood/genetics ; Child ; CpG Islands/genetics ; DNA Methylation/*genetics ; Eosinophils/cytology/metabolism ; Epigenesis, Genetic/*genetics ; Female ; *Genetic Association Studies ; Genome, Human/*genetics ; Humans ; Immunoglobulin E/*blood ; Inflammation Mediators ; Male ; Middle Aged ; Mitochondrial Proteins/genetics ; Pedigree ; Polymorphism, Single Nucleotide/genetics ; Transcription Factors/genetics ; Young Adult
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 8
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    Inferring probabilistic miRNA-mRNA interaction signatures in cancers: a role-switch approach (2014)
    Oxford University Press
    Details
    Publication Date: 2014-05-20
    Description: Aberrant microRNA (miRNA) expression is implicated in tumorigenesis. The underlying mechanisms are unclear because the regulations of each miRNA on potentially hundreds of mRNAs are sample specific. We describe a novel approach to infer  Pro babilistic  Mi RNA–mRNA I nteraction S ignatur e (‘ProMISe’) from a single pair of miRNA–mRNA expression profile. Our model considers mRNA and miRNA competition as a probabilistic function of the expressed seeds (matches). To demonstrate ProMISe, we extensively exploited The Cancer Genome Atlas data. As a target predictor, ProMISe identifies more confidence/validated targets than other methods. Importantly, ProMISe confers higher cancer diagnostic power than using expression profiles alone. Gene set enrichment analysis on averaged ProMISe uniquely revealed respective target enrichments of oncomirs miR-21 and 145 in glioblastoma and ovarian cancers. Moreover, comparing matched breast (BRCA) and thyroid (THCA) tumor/normal samples uncovered thousands of tumor-related interactions. For example, ProMISe–BRCA network involves miR-155/183/21, which exhibits higher ProMISe coupled with coherently higher miRNA expression and lower target expression; oncomirs miR-221/222 in the ProMISe–THCA network engage with many downregulated target genes. Together, our probabilistic approach of integrating expression and sequence scores establishes a functional link between the aberrant miRNA and mRNA expression, which was previously under-appreciated due to the methodological differences.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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  • 9
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    Genetic Basis of Differential Heat Resistance between Two Species of Congeneric Freshwater Snails: Insights from Quantitative Proteomics and Base Substitution Rate Analysis (2015)
    American Chemical Society (ACS)
    Details
    Publication Date: 2015-08-30
    Description: Journal of Proteome Research DOI: 10.1021/acs.jproteome.5b00462
    Print ISSN: 1535-3893
    Electronic ISSN: 1535-3907
    Topics: Chemistry and Pharmacology
    Published by American Chemical Society (ACS)
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  • 10
    Electronic Resource
    Electronic Resource
    Study of the morphology of the InAs-on-AlSb interface (1997)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 82 (1997), S. 4904-4907 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Using an atomic force microscope, we studied various InAs-on-AlSb interface structures grown by molecular beam epitaxy. We found marked differences between the effects of the two interface bond configurations—InSb-like and AlAs-like—on the morphology of the subsequent InAs layer. In general, InSb-like interfaces lead to a much smoother InAs overgrown layer with clearly resolvable monolayer terraces. AlAs-like interfaces, on the other hand, lead to increasingly rougher InAs growth with longer As exposure. Previous studies have demonstrated a strong correlation between the interface configuration and the electron mobility in the InAs quantum well. The morphology and transport results we obtained indicate one reason for the influence of the interface configuration—a rough InAs layer. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.366354
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    Paper (German National Licenses)
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