Publication Date:
1990-05-04
Description:
Gene products encoded by the human T cell leukemia virus (HTLV) types I and II mediate transformation by the transactivation of cellular genes necessary for proliferation, probably including transcriptional regulatory factors. By searching for factors that may control proliferation, a zinc finger gene (225) was identified that was constitutively expressed in all HTLV-I- or HTLV-II-transformed cell lines examined, whereas in normal T cells it was only transiently expressed after mitogenic stimulation. The 225 gene was also constitutively expressed in two HTLV-I-transformed helper T cell clones, but not in the parental cell lines. Thus this putative cellular transcriptional factor, which was abnormally expressed in retrovirus-infected cells, may have a role in transformation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wright, J J -- Gunter, K C -- Mitsuya, H -- Irving, S G -- Kelly, K -- Siebenlist, U -- New York, N.Y. -- Science. 1990 May 4;248(4955):588-91.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2110381" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Cell Line
;
*Cell Transformation, Viral
;
DNA-Binding Proteins/*genetics
;
Gene Expression Regulation, Viral
;
*Genes, Viral
;
Human T-lymphotropic virus 1/*genetics
;
Human T-lymphotropic virus 2/*genetics
;
Humans
;
Metalloproteins/*genetics
;
Molecular Sequence Data
;
T-Lymphocytes
;
Viral Structural Proteins/*genetics
;
Zinc/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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