ISSN:
1588-2780
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Energy, Environment Protection, Nuclear Power Engineering
Notes:
Abstract Results on aluminium and99mTc-MDP interaction under “in vivo” and “in vitro” conditions are presented. Aluminium, as chemical impurity, which in99mTc-eluate some times appears above the allowed concentration (more than 20 μg/ml) in the course of preparate labeling procedure may interact under in vitro conditions. Such a form of interaction was discovered by radiochromatographic methods. The highest Al3+-ion concentration studied (200 μg/ml) increases the99mTc-hydrolysate content by about ten times compared to the control. However, the same Al3+-ion concentration decreases by about four times the content of99mTc-MDP complex, which is responsible for deposition in bones. According to biodistribution results obtained on wistar rats, significant increase of radioactivity in liver is observed, and at the same time the decrease in bones, in dependence on the aluminium ion dose. With a maximum dose of 200 μg Al3+/kg b.w. the uptake of99mTc-MDP in liver was higher for about 35% and lower in bones for 3.6%/g. With compensan (antacide drug) with which the animals were primarily treated per os, only considerably small changes were observed in99mTc-MDP uptake, if compared to the control group. These findings are very important for clinical application of this preparate.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02037163
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