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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Annals of biomedical engineering 4 (1976), S. 280-301 
    ISSN: 1573-9686
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract The previously limited dipole or vector concept in electrocardiography may now be extended to the multipole concept, and the extraction of otherwise lost surface reflections of myocardial electrical activity may now be obtained. The geometric form and orientation for each of the 15 components of a three-stage multipole located at the heart's center have been characterized. This permitted determination of the patterns of potential distribution on the chest resulting from the activation of each of the respective components. The 15 leads have been employed to determine dipolar-quadripolar-octapolar moment of instantaneous body surface potentials, first calculated from a 20-dipole model of ventricular depolarization and, second, actually recorded from normal human subjects. The new information in the quadripolar and octapolar leads appears related both to the anatomic displacement of the mean heart vector and to the estimate of opposed simultaneous electrical forces in the myocardium which ordinarily average or “cancel out” in conventional electrocardiographic and vectorcardiographic leads and thus go unreported. Octapolar strength was found to be greatest in mid-QRS in normal subjects but less than quadripolar in early and late QRS. The quadripolar strength remained approximately one-half that of the dipole or heart vector throughout the heart cycle.
    Type of Medium: Electronic Resource
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  • 2
    Publication Date: 2021-10-26
    Description: Patients with coronavirus disease 2019 (COVID-19) can have increased risk of mortality shortly after intubation. The aim of this study is to develop a model using predictors of early mortality after intubation from COVID-19. A retrospective study of 1945 intubated patients with COVID-19 admitted to 12 Northwell hospitals in the greater New York City area was performed. Logistic regression model using backward selection was applied. This study evaluated predictors of 14-day mortality after intubation for COVID-19 patients. The predictors of mortality within 14 days after intubation included older age, history of chronic kidney disease, lower mean arterial pressure or increased dose of required vasopressors, higher urea nitrogen level, higher ferritin, higher oxygen index, and abnormal pH levels. We developed and externally validated an intubated COVID-19 predictive score (ICOP). The area under the receiver operating characteristic curve was 0.75 (95% CI 0.73–0.78) in the derivation cohort and 0.71 (95% CI 0.67–0.75) in the validation cohort; both were significantly greater than corresponding values for sequential organ failure assessment (SOFA) or CURB-65 scores. The externally validated predictive score may help clinicians estimate early mortality risk after intubation and provide guidance for deciding the most effective patient therapies.
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Springer Nature
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