Publication Date:
2015-12-09
Description:
Article Type IIA topoisomerases (topo2As) create transient double-strand DNA breaks. Here, the authors report structures showing how QPT-1 binds in the DNA/topo2A complex at the same site as the fluoroquinolone moxifloxacin, and discuss the potential for developing new classes of antibiotics. Nature Communications doi: 10.1038/ncomms10048 Authors: Pan F. Chan, Velupillai Srikannathasan, Jianzhong Huang, Haifeng Cui, Andrew P. Fosberry, Minghua Gu, Michael M. Hann, Martin Hibbs, Paul Homes, Karen Ingraham, Jason Pizzollo, Carol Shen, Anthony J. Shillings, Claus E. Spitzfaden, Robert Tanner, Andrew J. Theobald, Robert A. Stavenger, Benjamin D. Bax, Michael N. Gwynn
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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