ISSN:
1052-9306
Keywords:
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
This report describes a highly sensitive capillary gas chromatographic/mass spectrometric procedure for the quantification of alprazolam in human plasma. Alprazolam was extracted from plasma at basic pH with benzeneisoamyl alcohol (98:2, v/v) and analysed directly without any derivatization. Triazolam, also a triazolobenzo-diazepine derivative, was used as an internal standard because its extraction characteristics were similar to alprazolam. High sensitivity was achieved by negative ion chemical ionization and selected ion monitoring for alprazolam (m/z 308) and triazolam (m/z 306). The within-day coefficient of variation of the method over the concentration range 1.0-20 ng alprazolam per ml of plasma was 5.5%.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/bms.1200130306
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