ISSN:
1588-2780
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Energy, Environment Protection, Nuclear Power Engineering
Notes:
Abstract A new, aqueous phase preparation procedure for123I-mIBG /meta-iodobenzylguanidine/ is described. It comprises a copper-catalyzed exchange reaction between aqueous123I-iodide and mIBG at 150 °C for 45 min, a purification via anion-exchange chromatography, and a sterilization via micropore filtration. Overall preparative yield, radiochemical purity and specific activity amount to 〉90%, 〉99.7% and 〉1015 Bq.mol−1 mIBG, respectively. Other features are simplicity /no evaporation of water or other solvents/, reproducibility of labelling yield and radiochemical purity, and speed /total time required 1.5 h/.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02163075
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