ISSN:
1588-2780
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Energy, Environment Protection, Nuclear Power Engineering
Notes:
Abstract 99mTc-Hipp as a modified99mTc-DTPA, and99mTc-PAH as a new renal agent are developed. Each veal of lyophilised kit contain hippuric (Hipp) or p-aminohippuric acid (PAH), diethyltriaminepentaacetic acid as calciumtrisodium salt (CaNa3DTPA) and stannouschloride (SnCl2·xH2O), in molar ratio Hipp/PAH:DTPA=4∶1. They are high radiochemical purity radiopharmaceuticals, with hydrophilic character and low percentage of protein binding. The ITL chromatography and HPLC analyses of these labeled compounds have shown almost identical results as99mTc-DTPA, but their biological behavior in rats confirm certain differences.99mTc-Hipp is a renal agent clearing by the glomerular system, with better pharmacokinetical parameters than99mTc-DTPA:t 1/2(α)=4.1 min,t 1/2(β)=198.6 min,K cl=1.2·10−2min−1 and a twofold value for blood clearance (Cl=2.07 ml/min).99mTc-PAH is a quite different renal agent, rapidly secreted by kidney as a tubular secretion agent. Its pharmacokinetical parameters:t 1/2(α)=2.5 min,t 1/2(β)=41.7 min andK cl=5.1·10−4 min−1 are almost equal to those of99mTc-MAG3, but the blood clearance of Cl=5.22 ml/min is even higher than that of IOH clearance.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02345554
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