Publication Date:
2017-08-19
Description:
Atg4 proteolytic activity can be inhibited by Atg1 phosphorylation Nature Communications, Published online: 18 August 2017; doi:10.1038/s41467-017-00302-3 The protease Atg4 mediates Atg8 lipidation, required for autophagosome biogenesis, but also triggers Atg8 release from the membranes, however is unclear how these steps are coordinated. Here the authors show that phosphorylation by Atg1 inhibits Atg4 at autophagosome formation sites.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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