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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of chemical information and modeling 17 (1977), S. 148-157 
    ISSN: 1520-5142
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Bradford : Emerald
    Health manpower management 23 (1997), S. 233-236 
    ISSN: 0955-2065
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Medicine , Economics
    Notes: Government interest in health service "did not attend" (DNA) rates was seen to occur by accident, following which efforts to reduce DNAs have tended to concentrate on operational rather than strategic issues. Considers the effect hospital culture has had on DNA rates from an organizational and patient perspective. Identifies some of the key cultural issues that impacted on DNA rates by utilizing observation and telephone survey research methods. Concludes that , in the main, the lack of customer-oriented organizational culture was seen to affect DNA rates adversely within one NHS provider trust.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 418 (1983), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-0878
    Keywords: Molecular chaperone p26 hsp70 and 90 Artemin Stress tolerance Anoxic cell ultrastructure Dense nuclear granules Brine shrimp (Artemia franciscana Crustacea)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. Cells of encysted embryos of Artemia franciscana, the brine shrimp, are among the most resistant of all animal cells to extremes of environmental stress. We focus here on their ability to survive continuous anoxia for periods of years, during which their metabolic rate is undetectable. We asked whether their impressive tolerance was reflected in changes at the ultrastructural level. The ultrastructure of encysted embryos previously experiencing 38 days and 3.3 years of anoxia was compared with those not undergoing anoxia (controls). Rough endoplasmic reticulum was abundant in anoxic embryos, in spite of the absence of protein biosynthesis in their cells. Other cytoplasmic changes had occurred in the anoxic cells, but overall their structure was remarkably intact, in view of their 3 years of continuous anoxia. A major difference was the presence of abundant electron-dense granules in the nuclei of anoxic embryos; these were present but rare in nuclei of controls. Biochemical fractionation and Western immunoblotting confirmed previous observations that substantial amounts of the small heat shock/α-crystallin protein (p26) translocated into nuclei of anoxic embryos. We have no evidence that the dense granules contain this protein, but that remains a possibility. In contrast, and contrary to expectation, proteins of the hsp70 and 90 families did not undergo anoxia-induced nuclear translocation, an unusual result since such translocations have been widely observed in cells from a variety of organisms.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    International journal of salt lake research 6 (1997), S. 207-216 
    ISSN: 1573-8590
    Keywords: ancient DNA ; Artemia franciscana ; brine shrimp ; geologic cores ; Great Salt Lake ; palaeobiochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geography
    Notes: Abstract We present electron microscopic observations on fragments of encysted embryos of the crustacean,Artemia sp., recovered from a 27,000 year-old core section taken under the Great Salt Lake (GSL), Utah. The significance of these results comes from a consideration of the geological history of the GSL and the extraordinary properties and abundance ofArtemia cysts at this site. We make the case that this unique system, and probably other salt lakes as well, provides novel opportunities for the study of “ancient DNA” and related matters. The analysis provides the major focus of this paper, which we hope will stimulate interest in this aspect of salt lake research.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    International journal of salt lake research 6 (1997), S. 207-216 
    ISSN: 1573-8590
    Keywords: ancient DNA ; Artemia franciscana ; brine shrimp ; geologic cores ; Great Salt Lake ; palaeobiochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geography
    Notes: Abstract We present electron microscopicobservations on fragments of encysted embryos of thecrustacean, Artemia sp., recovered from a 27,000year-old core section taken under the Great Salt Lake(GSL), Utah. The significance of these results comesfrom a consideration of the geological history of theGSL and the extraordinary properties and abundance ofArtemia cysts at this site. We make the casethat this unique system, and probably other salt lakesas well, provides novel opportunities for the studyof “ancient DNA” and related matters. The analysisprovides the major focus of this paper, which we hopewill stimulate interest in this aspect of salt lakeresearch.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1573-5117
    Keywords: biological integrity ; ecological integrity ; bioassessment ; biocriteria ; water quality ; biological indicators
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The concept of ecological integrity has become a worldwide phenomenon and is firmly entrenched into the regulatory structure of environmental law in the United States of America (USA). The attainment of ecological integrity requires the attainment of its three elements: physical, chemical, and biological integrity. In the USA, measures of chemical integrity were implemented first into monitoring programs and were effective in reducing pollutant loadings to the nation's surface waters. Because biological communities integrate the effects of different stressors such as reduced oxygen, excess nutrients, toxic chemicals, increased temperature, excessive sediment loading, and habitat degradation, the advent of bioassessment in regulatory programs has provided a more comprehensive and effective monitoring and assessment strategy. Measures of biological integrity clearly have become a priority in the USA. The development of biological criteria (biocriteria) within regulatory programs to serve as thresholds by which to judge the attainment of designated aquatic life conditions of surface waters is a major focus of states and Indian tribes within the USA. The derivation of reference conditions for the nation's surface waters (i.e., streams, rivers, lakes, wetlands, estuaries, and marine waters) across different physiographic regions is a critical element in the design of biocriteria and is currently a primary initiative in the USA. Nearly all state water resource agencies have developed bioassessment approaches for streams; 1600 to 75 000 km of streams require assessment in each state. Bioassessment development for other water body types is not as advanced to date. The US Environmental Protection Agency (USEPA) has produced technical guidance for developing effective bioassessment programs; they include crucial elements such as defining objectives, classifying water bodies according to expected biological attributes, deriving the reference condition of the site classes, developing standardized protocols for sampling and data analysis, and implementing a quality assurance plan. Approaches to bioassessment in the USA follow a basic design of incorporating various attributes of the elements and processes of the aquatic community, which is either an aggregation into a multimetric index or a series of multivariate analyses using the attributes as input variables. The Clean Water Act of 1972 and its subsequent amendments mandate maintaining, restoring, and protecting the ecological integrity of surface waters. Through use of robust bioassessments and other measures of ecological integrity, the USA has developed a strategic plan to establish priorities to meet this goal.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 142 (1990), S. 386-391 
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Mouse L-929 cells were subjected to increasing concentrations of sorbitol, which remove cell water and reduce volume osmotically. The rate of lactate production from glucose was significantly higher in osmotically perturbed cells than in controls, both in monolayers and in suspensions. L cells can apparently use sorbitol as a glycolytic substrate; however, studies using other solutes (trehalose and sucrose) and permeabilized cells showed that the major effect of scrbitol on glycolysis in intact cells is mediated through a reduction in cell water content and volume. It is possible to explain some of these results by an increase in the chemical potentials of dissolved components of the glycolytic pathway caused by water loss; however, the relationship between water loss and glycolytic rate increase in not a simple linear one, suggesting that the situation is more complex than would result merely from increased concentrations of pathway components. Whatever the complete explanation might be, these studies show that glycolysis continues in an orderly fashion in cells that have lost about 85% of their original water content, suggesting that the operation of this pathway is not unduly sensitive to events taking place in the bulk aqueous phase.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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  • 9
  • 10
    Publication Date: 2000-07-12
    Print ISSN: 0302-766X
    Electronic ISSN: 1432-0878
    Topics: Biology , Medicine
    Published by Springer
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