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  • 1
    Electronic Resource
    Electronic Resource
    Biopharmaceutical and clinical pharmacokinetic profile of bromazepam (1976)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 4 (1976), S. 1-16 
    Details
    ISSN: 1573-8744
    Keywords: single dose ; multiple dose ; blood and urine levels ; predictable steady-state blood levels
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Bromazepam appears to be completely absorbed in man. The intact drug was eliminated from the blood with a mean half-life of 11.9 hr. Predictable steady-state blood levels are maintained on multiple daily dosing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01271440
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  • 2
    Electronic Resource
    Electronic Resource
    Utilization of area under the curve to elucidate the disposition of an extensively biotransformed drug (1973)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 1 (1973), S. 201-216 
    Details
    ISSN: 1573-8744
    Keywords: area analysis ; pharmacokinetic model ; rate constant determination ; biotransformation products ; computer simulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The principle of area analysis was used in the development of a metabolic and pharmacokinetic model for an extensively biotransformed drug. Area analysis was also used to determine the rate constants associated with the model. The drug used to exemplify the utility of area analysis in developing such a model was N4-ethoxyacetylsulfamethoxazole. Administration of this drug to the monkey results in three recognizable biotransformation products. Each of the four compounds was administered intravenously to a monkey on separate occasions. Excellent agreement was obtained between the simulated and actual blood levels of the intact drug and its three biotransformation products. Such agreement between the simulated and experimental data reflects the utility of area analysis as the basis for the design of a metabolic and pharmacokinetic model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01062347
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  • 3
    Electronic Resource
    Electronic Resource
    Pharmacokinetic and biopharmaceutic profile of chlordiazepoxide HCl in healthy subjects: Single-dose studies by the intravenous, intramuscular, and oral routes (1977)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 5 (1977), S. 3-23 
    Details
    ISSN: 1573-8744
    Keywords: chlordiazepoxide ; benzodiazepine ; two-compartment model, biopharmaceutics ; pharmacokinetics ; single dose ; routes of administration ; intravenous ; intramuscular ; oral
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Single 30- mg doses of chlordiazepoxide HCl were administered to six healthy human subjects by the intravenous, oral, and intramuscular routes. Plasma concentration- time curves following intravenous administration were satisfactorily described by a biexponential equation consistent with a two-compartment open model system. Mean values of half-lives for the so-called distribution and elimination phases were 0.252 and 9.39 hr, respectively. The mean values for the volume of the central compartment (V 1) and volume of distribution $$(V_{d_\beta } )$$ were 18.0 and 30.9% of body weight, respectively. Following oral administration, the drug was rapidly and completely absorbed. Absorption was first order (t1/2≈27 min), and three of the six subjects showed a discernible lag time of approximately 20 min. Drug absorption following intramuscular administration was comparatively slow. A two- compartment “muscle model” comprised of precipitated and solubilized drug in the muscle was found to satisfactorily characterize the absorption process following administration by this route.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01064806
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  • 4
    Electronic Resource
    Electronic Resource
    Pharmacokinetic and biopharmaceutic profile of chlordiazepoxide HCl in healthy subjects: Multiple-dose oral administration (1977)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 5 (1977), S. 25-39 
    Details
    ISSN: 1573-8744
    Keywords: chlordiazepoxide ; benzodiazepine ; two-compartment model ; multiple dosing ; pharmacokinetics ; biopharmaceutics ; metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Eight healthy male volunteers received chlordiazepoxide HCl orally at a dosage of 10 mg every 8 hr over a period of 21 days. On day 22, the regimen was changed to 30 mg every 24 hr for an additional 15 days. Plasma concentrations of chlordiazepoxide and its metabolites desmethyl-chlordiazepoxide, demoxepam, and desoxydemoxepam were measured during 14 of the 36 treatment days. Chlordiazepoxide plasma concentration- time data were consistent with first-order absorption and complete bioavailability. The harmonic mean absorption half-life was 12.3 min. Disposition of chlordiazepoxide was described by a two-compartment open model with a harmonic mean terminal exponential half-life of 10.1 hr. Average steady — state plasma levels of chlordiazepoxide, desmethylchlordiazepoxide, and demoxepam were approximately 0.75, 0.54, and 0.36 μg/ml, respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01064807
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