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  • 1
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    Research on photoresponse characteristics of bilayer molybdenum disulfide field effect transistors (2018)
    Institute of Physics (IOP)
    Details
    Publication Date: 2018-07-13
    Description: The field-effect transistors (FETs) have attracted much attention because of the unique properties of the layered MoS 2 nanosheet as an ideal channel material. The phototransistors based on the MoS 2 FET have advantages of high photoresponsivity, rapid and stable response. This paper is concerned with the fabrication of bilayer MoS 2 based FET and the research on the photoelectric characteristics of the devices. The effect of the optical power and gate voltage on the photoelectric properties of the device was researched through the contrast experiments. It has been achieved that the photocurrent increases with the increase of optical power at the same gate voltage and drain voltage. The photoresponsivity also been enhanced with the gate voltage increased. And the photoresponsivity of bilayer MoS 2 FET was enhanced more than 100 folds by using MoS 2 /MoO 3 as the channel material. The results indicated that the MoS 2
    Print ISSN: 1757-8981
    Electronic ISSN: 1757-899X
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by Institute of Physics (IOP)
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  • 2
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    Optical Coherence in Atomic-Monolayer Transition-Metal Dichalcogenides Limited by Electron-Phonon Interactions (2016)
    American Physical Society (APS)
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    Publication Date: 2016-03-26
    Description: Author(s): P. Dey, J. Paul, Z. Wang, C. E. Stevens, C. Liu, A. H. Romero, J. Shan, D. J. Hilton, and D. Karaiskaj We systematically investigate the excitonic dephasing of three representative transition-metal dichalcogenides, namely, MoS 2 , MoSe 2 , and WSe 2 atomic monolayer thick and bulk crystals, in order to gain a proper understanding of the factors that determine the optical coherence in these materials. Cohe… [Phys. Rev. Lett. 116, 127402] Published Fri Mar 25, 2016
    Keywords: Condensed Matter: Electronic Properties, etc.
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
    Published by American Physical Society (APS)
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  • 3
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    Optical Control of Surface Anchoring and Reorientation of Liquid Crystals via a Plasmon-Enhanced Local Field (2012)
    American Physical Society (APS)
    Details
    Publication Date: 2012-10-03
    Description: Author(s): J. Shan, W. Shi, L. Y. Liu, Y. R. Shen, and L. Xu Gold nanoparticles deposited on the windows of a liquid crystal (LC) cell were found to be able to reduce the surface anchoring energy of the LC, and hence the threshold for its reorientation phase transition, by 1 to 2 orders of magnitude when a cw pump light was used to excite the local plasmon re... [Phys. Rev. Lett. 109, 147801] Published Tue Oct 02, 2012
    Keywords: Soft Matter, Biological, and Interdisciplinary Physics
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
    Published by American Physical Society (APS)
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  • 4
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    Pax2 regulates a fadd-dependent molecular switch that drives tissue fusion during eye development (2012)
    Oxford University Press
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    Publication Date: 2012-04-25
    Description: Tissue fusion is an essential morphogenetic mechanism in development, playing a fundamental role in developing neural tube, palate and the optic fissure. Disruption of genes associated with the tissue fusion can lead to congenital malformations, such as spina bifida, cleft lip/palate and ocular coloboma. For instance, the Pax2 transcription factor is required for optic fissure closure, although the mechanism of Pax2 action leading to tissue fusion remains elusive. This lack of information defining how transcription factors drive tissue morphogenesis at the cellular level is hampering new treatments options. Through loss- and gain-of-function analysis, we now establish that pax2 in combination with vax2 directly regulate the fas-associated death domain ( fadd ) gene. In the presence of fadd , cell proliferation is restricted in the developing eye through a caspase-dependent pathway. However, the loss of fadd results in a proliferation defect and concomitant activation of the necroptosis pathway through RIP1/RIP3 activity, leading to an abnormal open fissure. Inhibition of RIP1 with the small molecule drug necrostatin-1 rescues the pax2 eye fusion defect, thereby overcoming the underlying genetic defect. Thus, fadd has an essential physiological function in protecting the developing optic fissure neuroepithelium from RIP3-dependent necroptosis. This study demonstrates the molecular hierarchies that regulate a cellular switch between proliferation and the apoptotic and necroptotic cell death pathways, which in combination drive tissue morphogenesis. Furthermore, our data suggest that future therapeutic strategies may be based on small molecule drugs that can bypass the gene defects causing common congenital tissue fusion defects.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
    Published by Oxford University Press
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  • 5
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    Simultaneous detection of the spin-Hall magnetoresistance and the spin-Seebeck effect in platinum and tantalum on yttrium iron garnet (2014)
    American Physical Society (APS)
    Details
    Publication Date: 2014-11-27
    Description: Author(s): N. Vlietstra, J. Shan, B. J. van Wees, M. Isasa, F. Casanova, and J. Ben Youssef This is a simultaneous, but separate, detection of the spin Hall magnetoresistance and the spin Seebeck effect in Pt and Ta on YIG, by using a lock-in detection technique. In this way, the authors observe the dynamic behavior of the magnetization of the YIG, when applying low magnetic fields and high ac currents, i.e., in the regime where the system can be influenced by spin-transfer torques. They identify a new type of signal, present for small values of magnetic field, and demonstrate that this is due to changes in the spin Hall magnetoresistance signal caused by the Oersted-field-induced motion of the magnetic material. [Phys. Rev. B 90, 174436] Published Wed Nov 26, 2014
    Keywords: Magnetism
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 6
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    Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-03-09
    Description: The tumour suppressor ARF is specifically required for p53 activation under oncogenic stress. Recent studies showed that p53 activation mediated by ARF, but not that induced by DNA damage, acts as a major protection against tumorigenesis in vivo under certain biological settings, suggesting that the ARF-p53 axis has more fundamental functions in tumour suppression than originally thought. Because ARF is a very stable protein in most human cell lines, it has been widely assumed that ARF induction is mediated mainly at the transcriptional level and that activation of the ARF-p53 pathway by oncogenes is a much slower and largely irreversible process by comparison with p53 activation after DNA damage. Here we report that ARF is very unstable in normal human cells but that its degradation is inhibited in cancerous cells. Through biochemical purification, we identified a specific ubiquitin ligase for ARF and named it ULF. ULF interacts with ARF both in vitro and in vivo and promotes the lysine-independent ubiquitylation and degradation of ARF. ULF knockdown stabilizes ARF in normal human cells, triggering ARF-dependent, p53-mediated growth arrest. Moreover, nucleophosmin (NPM) and c-Myc, both of which are commonly overexpressed in cancer cells, are capable of abrogating ULF-mediated ARF ubiquitylation through distinct mechanisms, and thereby promote ARF stabilization in cancer cells. These findings reveal the dynamic feature of the ARF-p53 pathway and suggest that transcription-independent mechanisms are critically involved in ARF regulation during responses to oncogenic stress.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737736/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737736/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, Delin -- Shan, Jing -- Zhu, Wei-Guo -- Qin, Jun -- Gu, Wei -- P01 CA080058/CA/NCI NIH HHS/ -- P01 CA097403/CA/NCI NIH HHS/ -- R01 CA085533/CA/NCI NIH HHS/ -- R01 CA118561/CA/NCI NIH HHS/ -- R01 CA129627/CA/NCI NIH HHS/ -- R01 CA131439/CA/NCI NIH HHS/ -- England -- Nature. 2010 Mar 25;464(7288):624-7. doi: 10.1038/nature08820. Epub 2010 Mar 7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Cancer Genetics, and Department of Pathology and Cell Biology College of Physicians & Surgeons, Columbia University, 1130 St Nicholas Avenue, New York, New York 10032, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20208519" target="_blank"〉PubMed〈/a〉
    Keywords: ADP-Ribosylation Factors/*metabolism ; Cell Line ; Fibroblasts/metabolism ; *Gene Expression Regulation ; Humans ; Molecular Sequence Data ; Nuclear Proteins/metabolism ; Proto-Oncogene Proteins c-myc/metabolism ; Stress, Physiological/*physiology ; Tumor Suppressor Protein p53/*metabolism ; U937 Cells ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 7
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    Spin-Hall magnetoresistance in platinum on yttrium iron garnet: Dependence on platinum thickness and in-plane/out-of-plane magnetization (2013)
    American Physical Society (APS)
    Details
    Publication Date: 2013-05-21
    Description: Author(s): N. Vlietstra, J. Shan, V. Castel, B. J. van Wees, and J. Ben Youssef The occurrence of spin-Hall magnetoresistance (SMR) in platinum (Pt) on top of yttrium iron garnet (YIG) has been investigated, for both in-plane and out-of-plane applied magnetic fields and for different Pt thicknesses [3, 4, 8, and 35 nm]. Our experiments show that the SMR signal directly depends ... [Phys. Rev. B 87, 184421] Published Mon May 20, 2013
    Keywords: Magnetism
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 8
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    SCG10 promotes non-amyloidogenic processing of amyloid precursor protein by facilitating its trafficking to the cell surface (2013)
    Oxford University Press
    Details
    Publication Date: 2013-11-22
    Description: The processing of amyloid precursor protein (APP) is a key event in the pathogenesis of Alzheimer's disease. As certain cleavage pathways tend to occur in particular subcellular compartments, the processing of APP is greatly influenced by factors that regulate its trafficking. Here we report that SCG10 directly interacts with the KFFEQ motif of the APP intracellular domain and promotes the non-amyloidogenic processing of the APP. Knockdown of SCG10 led to decreases in α cleavage products, sAPPα and CTFα, while increases of both Aβ1–40 and Aβ1–42. Elevation of SCG10 induced APP accumulation in post-Golgi vesicles and on the cell surface by facilitating its secretory pathway. In addition, the APP processing was dependent on the palmitoylation-mediated membrane-anchoring of SCG10. Furthermore, elevation of SCG10 reduced Aβ accumulation and amyloid plaque formation in the hippocampus of APPswe/PS1dE9 mice. Taken together, these results show that SCG10 has a potential role in preventing and treating Alzheimer's disease.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
    Published by Oxford University Press
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  • 9
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    Temperature dependence of the magnon spin diffusion length and magnon spin conductivity in the magnetic insulator yttrium iron garnet (2016)
    American Physical Society (APS)
    Details
    Publication Date: 2016-11-05
    Description: Author(s): L. J. Cornelissen, J. Shan, and B. J. van Wees We present a systematic study of the temperature dependence of diffusive magnon spin transport using nonlocal devices fabricated on a 210-nm yttrium iron garnet film on a gadolinium gallium garnet substrate. In our measurements, we detect spin signals arising from electrical and thermal magnon gener… [Phys. Rev. B 94, 180402(R)] Published Fri Nov 04, 2016
    Keywords: Magnetism
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 10
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    Criteria for accurate determination of the magnon relaxation length from the nonlocal spin Seebeck effect (2017)
    American Physical Society (APS)
    Details
    Publication Date: 2017-11-23
    Description: Author(s): J. Shan, L. J. Cornelissen, J. Liu, J. Ben Youssef, L. Liang, and B. J. van Wees The nonlocal transport of thermally generated magnons not only unveils the underlying mechanism of the spin Seebeck effect, but also allows for the extraction of the magnon relaxation length ( λ m ) in a magnetic material, the average distance over which thermal magnons can propagate. In this study, we... [Phys. Rev. B 96, 184427] Published Wed Nov 22, 2017
    Keywords: Magnetism
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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