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  • 1
    Publication Date: 2016-07-27
    Description: Freshwater wetlands are particularly vulnerable to climate change. Specifically, changes in temperature, precipitation, and evapotranspiration (i.e., climate drivers) are likely to alter flooding regimes of wetlands and affect the vital rates, abundance, and distributions of wetland-dependent species. Amphibians may be among the most climate-sensitive wetland-dependent groups, as many species rely on shallow or intermittently flooded wetland habitats for breeding. Here, we integrated multiple years of high-resolution gridded climate and amphibian monitoring data from Grand Teton and Yellowstone National Parks to explicitly model how variations in climate drivers and habitat conditions affect the occurrence and breeding dynamics (i.e., annual extinction and colonization rates) of amphibians. Our results showed that models incorporating climate drivers outperformed models of amphibian breeding dynamics that were exclusively habitat based. Moreover, climate-driven variation in extinction rates, but not colonization rates, disproportionately influenced amphibian occupancy in monitored wetlands. Long-term monitoring from national parks coupled with high-resolution climate data sets will be crucial to describing population dynamics and characterizing the sensitivity of amphibians and other wetland-dependent species to climate change. Further, long-term monitoring of wetlands in national parks will help reduce uncertainty surrounding wetland resources and strengthen opportunities to make informed, science-based decisions that have far-reaching benefits.
    Electronic ISSN: 2150-8925
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by Wiley on behalf of The Ecological Society of America (ESA).
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  • 2
    Publication Date: 2016-06-30
    Description: Reconstructing historical colonization pathways of an invasive species is critical for uncovering factors that determine invasion success and for designing management strategies. The American bullfrog ( Lithobates catesbeianus ) is endemic to eastern North America, but now has a global distribution and is considered to be one of the worst invaders in the world. In Montana, several introduced populations have been reported, but little is known of their sources and vectors of introduction and secondary spread. We evaluated the genetic composition of introduced populations at local (Yellowstone River floodplain) and regional (Montana and Wyoming) scales in contrast to native range populations. Our objectives were to (1) estimate the number of introductions, (2) identify probable native sources, (3) evaluate genetic variation relative to sources, and (4) characterize properties of local- and regional-scale spread. We sequenced 937 bp of the mitochondrial cytochrome b locus in 395 tadpoles collected along 100 km of the Yellowstone River, from three additional sites in MT and a proximate site in WY. Pairwise Φ ST revealed high divergence among nonnative populations, suggesting at least four independent introductions into MT from diverse sources. Three cyt b haplotypes were identical to native haplotypes distributed across the Midwest and Great Lakes regions, and AMOVA confirmed the western native region as a likely source. While haplotype ( H d  = 0.69) and nucleotide diversity ( π  = 0.005) were low in introduced bullfrogs, the levels of diversity did not differ significantly from source populations. In the Yellowstone, two identified haplotypes implied few introduction vectors and a significant relationship between genetic and river distance was found. Evidence for multiple invasions and lack of subsequent regional spread emphasizes the importance of enforcing legislation prohibiting bullfrog importation and the need for continuing public education to prevent transport of bullfrogs in MT. More broadly, this study demonstrates how genetic approaches can reveal key properties of a biological invasion to inform management strategies. This study examined the invasion history of the American bullfrog ( Lithobates catesbeianus ) in Montana. Genetic data provided evidence for multiple independent introductions into the state from the western region of the North American native range, but little dispersal within the state. These data will inform appropriate management actions for identifying and controlling bullfrog importation and secondary spread.
    Electronic ISSN: 2045-7758
    Topics: Biology
    Published by Wiley
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  • 3
    Publication Date: 2011-04-20
    Description: Metabolic, infectious, and tumor cell-intrinsic noxae can all evoke the endoplasmic reticulum (ER) stress response in tumor cells, which is critical for tumor cell growth and cancer progression. Evidence exists that the ER stress response can drive a proinflammatory program in tumor cells and macrophages but, to our knowledge, a role for the tumor ER stress response in influencing macrophages and inflammation in the tumor microenvironment has not been suggested. Here we show that macrophages cultured in conditioned medium from ER-stressed tumor cells become activated, and themselves undergo ER stress with the up-regulation of Grp78, Gadd34, Chop, and Xbp-1 splicing, suggesting a general activation of the ER stress-signaling pathways. Furthermore, these macrophages recapitulate, amplify and expand the proinflammatory response of tumor cells. We term this phenomenon “transmissible” ER stress. Although neither Toll-like receptor (TLR)2 nor interleukin 6 receptor (IL6R) signaling is involved, a reduction was observed in the transmission of ER stress to TLR4 KO macrophages, consistent with the fact that a second signal through TLR4 combined with exposure to tumor ER stress-conditioned medium results in a faster ER stress response and an enhancement of proinflammatory cytokine production in macrophages. The injection of tumor ER stress-conditioned medium into WT mice elicited a generalized ER stress response in the liver. We suggest that transmissible ER stress is a mechanism through which tumor cells can control myeloid cells by directing them toward a proinflammatory phenotype, thus facilitating tumor progression.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 4
    Publication Date: 2013-10-09
    Description: Use of pesticides can have substantial nonlethal impacts on nontarget species, including driving evolutionary change, often with unknown consequences for species, ecosystems, and society. Hyalella azteca, a species complex of North American freshwater amphipods, is widely used for toxicity testing of water and sediment and has frequently shown toxicity due...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 5
    Publication Date: 2018-09-27
    Description: Despite the recognized significance of ground product fineness on both line capacity and downstream process performance (typically flotation), less than 10% of mineral ore concentrators today use real-time particle size measurements in automatic control applications for the final product particle size. Although “near-line” particle size measurement instrumentation has been in place for several decades and is commonly installed in most modern concentrators, its availability and low measurement frequency have typically been inadequate for reliable use in automatic control. Their low availability is often associated with problems with slurry sample collection and handling systems required to present the samples to the size measurement instrument. Recently, an innovative technology for real-time, on-line particle size measurement has been developed by CiDRA Minerals Processing, under its commercial name Particle Size Tracking (PST), already proven in several commercial installations...
    Print ISSN: 1757-8981
    Electronic ISSN: 1757-899X
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
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  • 6
    Publication Date: 2009-10-03
    Description: The course of the biotic recovery after the impact-related disruption of photosynthesis and mass extinction event at the Cretaceous-Paleogene boundary has been intensely debated. The resurgence of marine primary production in the aftermath remains poorly constrained because of the paucity of fossil records tracing primary producers that lack skeletons. Here we present a high-resolution record of geochemical variation in the remarkably thick Fiskeler (also known as the Fish Clay) boundary layer at Kulstirenden, Denmark. Converging evidence from the stable isotopes of carbon and nitrogen and abundances of algal steranes and bacterial hopanes indicates that algal primary productivity was strongly reduced for only a brief period of possibly less than a century after the impact, followed by a rapid resurgence of carbon fixation and ecological reorganization.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sepulveda, Julio -- Wendler, Jens E -- Summons, Roger E -- Hinrichs, Kai-Uwe -- New York, N.Y. -- Science. 2009 Oct 2;326(5949):129-32. doi: 10.1126/science.1176233.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Organic Geochemistry Group, Department of Geosciences, and Center for Marine Environmental Sciences (MARUM), University of Bremen, 28334 Bremen, Germany. juliosep@mit.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19797658" target="_blank"〉PubMed〈/a〉
    Keywords: Biomarkers/analysis ; Carbon Isotopes ; Cyanobacteria/physiology ; Denmark ; *Ecosystem ; Eukaryota/*physiology ; *Extinction, Biological ; Geologic Sediments ; Nitrogen Isotopes ; Photosynthesis ; Phytoplankton/physiology ; Polycyclic Compounds/analysis ; Seawater/chemistry/*microbiology ; Time ; Triterpenes/analysis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-09-13
    Description: The global health landscape looks more promising than ever, although progress has been uneven. Here, we describe the current global burden of disease throughout the life cycle, highlighting regional differences in the unfinished agenda of communicable diseases and reproductive, maternal, and child health and the additive burden of emerging noncommunicable diseases and injuries. Understanding this changing landscape is an essential starting point for effective allocation of both domestic and international resources for health.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sepulveda, Jaime -- Murray, Christopher -- New York, N.Y. -- Science. 2014 Sep 12;345(6202):1275-8. doi: 10.1126/science.1257099.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Global Health Sciences, University of California (UC) San Francisco, San Francisco, CA, USA. sepulvedaj@globalhealth.ucsf.edu. ; Institute for Health Metrics and Evaluation (IHME), University of Washington, Seattle, WA, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25214611" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Age Factors ; Aged ; Child ; Child Welfare/trends ; Child, Preschool ; Communicable Diseases/epidemiology ; *Cost of Illness ; Diabetes Mellitus/epidemiology ; Emergencies/epidemiology ; Female ; Global Health/*trends ; Humans ; Infant ; Infant, Newborn ; Male ; Maternal Welfare/trends ; Middle Aged ; Obesity/epidemiology ; Prevalence ; Reproductive Health/trends ; Wounds and Injuries/epidemiology ; Young Adult
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Mutation Research/Environmental Mutagenesis and Related Subjects 97 (1982), S. 203 
    ISSN: 0165-1161
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Two nodulation regions from the symbiotic plasmid (pSym) of Rhizobium phaseoil CE-3 were identified. The two regions were contained in overlapping cosmids pSM927 and pSM991. These cosmids, in a R phaseoli pSym-cured strain background, induced ineffective nodules on Phaseolus vulgaris roots.Transconjugants of Rhizobium meliloti harbouring pSM991 induced nodule-like structures on bean roots, suggesting that this cosmid contains host-range determinants.Analysis of deletions and insertional mutations in the sequences of pSM991 indicated that the genes responsible for the induction and development of nodules in P. vulgaris are organized in two regions 20kb apart. One region, located in a 6.8kb Eco RI fragment, includes the common nodABC genes. The other region, located in a 3.5kb EcoRI fragment, contains information required for host-range determination.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 569 (1989), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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