Publication Date:
2013-09-21
Description:
Opioid receptor antagonists increase hyperalgesia in humans and animals, which indicates that endogenous activation of opioid receptors provides relief from acute pain; however, the mechanisms of long-term opioid inhibition of pathological pain have remained elusive. We found that tissue injury produced mu-opioid receptor (MOR) constitutive activity (MOR(CA)) that repressed spinal nociceptive signaling for months. Pharmacological blockade during the posthyperalgesia state with MOR inverse agonists reinstated central pain sensitization and precipitated hallmarks of opioid withdrawal (including adenosine 3',5'-monophosphate overshoot and hyperalgesia) that required N-methyl-D-aspartate receptor activation of adenylyl cyclase type 1. Thus, MOR(CA) initiates both analgesic signaling and a compensatory opponent process that generates endogenous opioid dependence. Tonic MOR(CA) suppression of withdrawal hyperalgesia may prevent the transition from acute to chronic pain.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440417/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440417/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Corder, G -- Doolen, S -- Donahue, R R -- Winter, M K -- Jutras, B L -- He, Y -- Hu, X -- Wieskopf, J S -- Mogil, J S -- Storm, D R -- Wang, Z J -- McCarson, K E -- Taylor, B K -- 5K02DA19656/DA/NIDA NIH HHS/ -- F31 DA032496/DA/NIDA NIH HHS/ -- F31DA032496/DA/NIDA NIH HHS/ -- HD02528/HD/NICHD NIH HHS/ -- K02 DA019656/DA/NIDA NIH HHS/ -- P30 HD002528/HD/NICHD NIH HHS/ -- R01 NS045954/NS/NINDS NIH HHS/ -- R01NS45954/NS/NINDS NIH HHS/ -- UL1 TR000117/TR/NCATS NIH HHS/ -- New York, N.Y. -- Science. 2013 Sep 20;341(6152):1394-9. doi: 10.1126/science.1239403.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology, University of Kentucky, Lexington, KY 40536, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24052307" target="_blank"〉PubMed〈/a〉
Keywords:
Acute Pain/metabolism
;
Adenosine Monophosphate/metabolism
;
Adenylyl Cyclases/metabolism
;
Animals
;
Chronic Pain/*metabolism
;
Disease Models, Animal
;
Freund's Adjuvant/pharmacology
;
Hyperalgesia/chemically induced/*metabolism
;
Isoflurane/pharmacology
;
Male
;
Mice
;
Naltrexone/analogs & derivatives/pharmacology
;
Nociceptive Pain/*metabolism
;
Receptors, N-Methyl-D-Aspartate/metabolism
;
Receptors, Opioid, mu/agonists/antagonists & inhibitors/*metabolism
;
Spinal Cord/drug effects/metabolism
;
Substance Withdrawal Syndrome/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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