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  • 1
    Publication Date: 2019
    Description: 〈p〉Detection of amyloid-β (Aβ) aggregates contributes to the diagnosis of Alzheimer disease (AD). Plasma Aβ is deemed a less invasive and more accessible hallmark of AD, as Aβ can penetrate blood-brain barriers. However, correlations between biofluidic Aβ concentrations and AD progression has been tenuous. Here, we introduce a diagnostic technique that compares the heterogeneous and the monomerized states of Aβ in plasma. We used a small molecule, EPPS [4-(2-hydroxyethyl)-1-piperazinepropanesulfonic acid], to dissociate aggregated Aβ into monomers to enhance quantification accuracy. Subsequently, Aβ levels of EPPS-treated plasma were compared to those of untreated samples to minimize inter- and intraindividual variations. The interdigitated microelectrode sensor system was used to measure plasma Aβ levels on a scale of 0.1 pg/ml. The implementation of this self-standard blood test resulted in substantial distinctions between patients with AD and individuals with normal cognition (NC), with selectivity and sensitivity over 90%.〈/p〉
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
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  • 2
    Publication Date: 2015-08-01
    Description: Jumping on water is a unique locomotion mode found in semi-aquatic arthropods, such as water striders. To reproduce this feat in a surface tension-dominant jumping robot, we elucidated the hydrodynamics involved and applied them to develop a bio-inspired impulsive mechanism that maximizes momentum transfer to water. We found that water striders rotate the curved tips of their legs inward at a relatively low descending velocity with a force just below that required to break the water surface (144 millinewtons/meter). We built a 68-milligram at-scale jumping robotic insect and verified that it jumps on water with maximum momentum transfer. The results suggest an understanding of the hydrodynamic phenomena used by semi-aquatic arthropods during water jumping and prescribe a method for reproducing these capabilities in artificial systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koh, Je-Sung -- Yang, Eunjin -- Jung, Gwang-Pil -- Jung, Sun-Pill -- Son, Jae Hak -- Lee, Sang-Im -- Jablonski, Piotr G -- Wood, Robert J -- Kim, Ho-Young -- Cho, Kyu-Jin -- New York, N.Y. -- Science. 2015 Jul 31;349(6247):517-21. doi: 10.1126/science.aab1637. Epub 2015 Jul 30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Biorobotics Laboratory, Department of Mechanical and Aerospace Engineering, Seoul National University, Seoul 151-744, Korea. School of Engineering and Applied Sciences and Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA 02138, USA. hyk@snu.ac.kr kjcho@snu.ac.kr. ; Micro Fluid Mechanics Laboratory, Department of Mechanical and Aerospace Engineering, Seoul National University, Seoul 151-744, Korea. hyk@snu.ac.kr kjcho@snu.ac.kr. ; Biorobotics Laboratory, Department of Mechanical and Aerospace Engineering, Seoul National University, Seoul 151-744, Korea. ; Laboratory of Behavioral Ecology and Evolution, School of Biological Sciences, Seoul National University, Seoul 151-742, Korea. ; Laboratory of Behavioral Ecology and Evolution, School of Biological Sciences, Seoul National University, Seoul 151-742, Korea. Institute of Advanced Machines and Design, Seoul National University, Seoul 151-744, Korea. ; Laboratory of Behavioral Ecology and Evolution, School of Biological Sciences, Seoul National University, Seoul 151-742, Korea. Museum and Institute of Zoology, Polish Academy of Sciences, Warsaw 00-679, Poland. ; School of Engineering and Applied Sciences and Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA 02138, USA. ; Micro Fluid Mechanics Laboratory, Department of Mechanical and Aerospace Engineering, Seoul National University, Seoul 151-744, Korea. Institute of Advanced Machines and Design, Seoul National University, Seoul 151-744, Korea. ; Biorobotics Laboratory, Department of Mechanical and Aerospace Engineering, Seoul National University, Seoul 151-744, Korea. Institute of Advanced Machines and Design, Seoul National University, Seoul 151-744, Korea.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26228144" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biomechanical Phenomena ; Extremities/physiology ; Heteroptera/*physiology ; Hydrodynamics ; *Locomotion ; Robotics ; Rotation ; Surface Tension ; *Water
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 72 (1992), S. 5393-5396 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The semiquantitative analysis of optical absorption for interstitial oxygen in silicon was carried out using the molecular orbital theory and compared with results from Fourier transform-infrared equipment having a high resolution of 0.05 cm−1. Six finely split peaks were observed with the wave numbers of 1120.2, 1123.6, 1128.3, 1132.8, 1133.5, and 1136.4 cm−1 at 30 K, among which 1120.2, 1132.8, and 1133.5 cm−1 were newly observed. It is concluded that there seems to be a reliable correlation between the observed band splitting and the likely energy transitions from an S6 symmetry model. Fine splitting of the absorption peaks at low temperature indicates the close relationship between the local Si—O—Si bond and six nearest neighbor silicon atoms forming S6 symmetry. Absorption peaks also were narrower and higher as the measurement temperature was lowered. Hence, it can be said that low-temperature measurement improves the oxygen detectability by a factor of 10 compared with measurement at room temperature.
    Type of Medium: Electronic Resource
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  • 4
    Publication Date: 2018-04-27
    Description: Mechanical power limitations emerge from the physical trade-off between force and velocity. Many biological systems incorporate power-enhancing mechanisms enabling extraordinary accelerations at small sizes. We establish how power enhancement emerges through the dynamic coupling of motors, springs, and latches and reveal how each displays its own force-velocity behavior. We mathematically demonstrate a tunable performance space for spring-actuated movement that is applicable to biological and synthetic systems. Incorporating nonideal spring behavior and parameterizing latch dynamics allows the identification of critical transitions in mass and trade-offs in spring scaling, both of which offer explanations for long-observed scaling patterns in biological systems. This analysis defines the cascading challenges of power enhancement, explores their emergent effects in biological and engineered systems, and charts a pathway for higher-level analysis and synthesis of power-amplified systems.
    Keywords: Engineering, Online Only
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 1992-12-01
    Print ISSN: 0021-8979
    Electronic ISSN: 1089-7550
    Topics: Physics
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