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  • 1
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    The four and a half LIM domains 2 (FHL2) regulates ovarian granulosa cell tumor progression via controlling AKT1 transcription (2016)
    Springer Nature
    Details
    Publication Date: 2016-07-15
    Description: The four and a half LIM domains 2 (FHL2) regulates ovarian granulosa cell tumor progression via controlling AKT1 transcription Cell Death and Disease 7, e2297 (July 2016). doi:10.1038/cddis.2016.207 Authors: G Hua, C He, X Lv, L Fan, C Wang, S W Remmenga, K J Rodabaugh, L Yang, S M Lele, P Yang, A R Karpf, J S Davis & C Wang
    Electronic ISSN: 2041-4889
    Topics: Biology , Medicine
    Published by Springer Nature
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  • 2
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    Accounting for residential propagule pressure improves prediction of urban plant invasion (2016)
    Wiley
    In: Ecosphere
    Details
    Publication Date: 2016-03-09
    Description: Plant invasions substantially impact the ecosystem services provided by forests in urbanizing regions. Knowing where invasion risk is greatest helps target early detection and eradication efforts, but developing an accurate predictive model of invasive species presence and spread on the basis of habitat suitability remains a challenge due to spatial variation in propagule pressure (the number of individuals released) which is likely conflated with suitability. In addition to neighborhood propagule pressure that originates with propagules dispersing from naturalized populations within invaded habitats, we expect residential propagule pressure arising from the widespread use of exotic plants in the yards of single-family residences to be an important driver of invasions, and to notably improve the predictive accuracy of species distribution models (SDMs). To this end, we collected presence/absence data for a widespread forest invader, Ligustrum sinense (Chinese privet) , from 400 stratified random plots located along an urban gradient across the Charlotte, North Carolina metropolitan area. We assessed the relative contribution of residential propagule pressure and neighborhood propagule pressure to improving the predictive performance of a probit SDM for Chinese privet that only contains environmental predictors. Our results indicate that, although the environment-only model predicted the highest geographic area to be at risk of invasion by privet, it also had the highest rate of failure to accurately predict observed privet occurrences as indicated by the omission (incorrectly predicted absence) and commission (incorrectly predicted presence) error rates. Accounting for residential propagule pressure substantially improved model performance by reducing the omission error by nearly 50%, thereby improving upon the ability of the model to predict privet invasion in suboptimal habitat. Given that this increase in detection was accompanied by a decrease in the geographic area predicted at risk, we conclude that SDMs for invasive exotic shrubs and potentially for other synanthropic generalist plants may be highly inefficient when residential propagule pressure is not accounted for. Accounting for residential propagule pressure in models of invasive plants results in a more focused and accurate prediction of the area at risk, thus enabling decision makers to feasibly prioritize regional scale monitoring and control efforts.
    Electronic ISSN: 2150-8925
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by Wiley on behalf of The Ecological Society of America (ESA).
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  • 3
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    Measurements of laser generated soft X-ray emission from irradiated gold foils (2016)
    American Institute of Physics (AIP)
    Details
    Publication Date: 2016-08-23
    Description: Soft x-ray emission from laser irradiated gold foils was measured at the Omega-60 laser system using the Dante photodiode array. The foils were heated with 2 kJ, 6 ns laser pulses and foil thicknesses were varied between 0.5, 1.0, and 2.0 μm. Initial Dante analysis indicates peak emission temperatures of roughly 100 eV and 80 eV for the 0.5 μ m and 1.0 μ m thick foils, respectively, with little measurable emission from the 2.0 μ m foils.
    Print ISSN: 0034-6748
    Electronic ISSN: 1089-7623
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Published by American Institute of Physics (AIP)
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  • 4
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    The G-protein-coupled estrogen receptor agonist G-1 suppresses proliferation of ovarian cancer cells by blocking tubulin polymerization (2013)
    Springer Nature
    Details
    Publication Date: 2013-10-18
    Description: The G-protein-coupled estrogen receptor agonist G-1 suppresses proliferation of ovarian cancer cells by blocking tubulin polymerization Cell Death and Disease 4, e869 (October 2013). doi:10.1038/cddis.2013.397 Authors: C Wang, X Lv, C He, G Hua, M-Y Tsai & J S Davis
    Keywords: GPERG-1ovarian cancercell proliferationapoptosis
    Electronic ISSN: 2041-4889
    Topics: Biology , Medicine
    Published by Springer Nature
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  • 5
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    ASASSN-14ae: a tidal disruption event at 200 Mpc (2014)
    Oxford University Press
    Details
    Publication Date: 2014-10-26
    Description: ASASSN-14ae is a candidate tidal disruption event (TDE) found at the centre of SDSS J110840.11+340552.2 ( d ~= 200 Mpc) by the All-Sky Automated Survey for Supernovae (ASAS-SN). We present ground-based and Swift follow-up photometric and spectroscopic observations of the source, finding that the transient had a peak luminosity of L ~= 8 10 43  erg s –1 and a total integrated energy of E ~= 1.7 10 50 erg radiated over the ~5 months of observations presented. The blackbody temperature of the transient remains roughly constant at T  ~ 20 000 K while the luminosity declines by nearly 1.5 orders of magnitude during this time, a drop that is most consistent with an exponential, L e - t/t 0 with t 0 ~= 39 d. The source has broad Balmer lines in emission at all epochs as well as a broad He  ii feature emerging in later epochs. We compare the colour and spectral evolution to both supernovae and normal AGN to show that ASASSN-14ae does not resemble either type of object and conclude that a TDE is the most likely explanation for our observations. At z  = 0.0436, ASASSN-14ae is the lowest-redshift TDE candidate discovered at optical/UV wavelengths to date, and we estimate that ASAS-SN may discover 0.1–3 of these events every year in the future.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
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  • 6
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    Insulin rapidly increases diacylglycerol by activating de novo phosphatidic acid synthesis (1987)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1987-05-01
    Description: The mechanisms whereby insulin increases diacylglycerol in BC3H-1 myocytes were examined. When [3H]arachidonate labeling of phospholipids was used as an indicator of phospholipase C activation, transient increases in [3H]diacylglycerol were observed between 0.5 and 10 minutes after the onset of insulin treatment. With [3H]glycerol labeling as an indicator of de novo phospholipid synthesis, [3H]diacylglycerol was increased maximally at 1 minute and remained elevated for 20 minutes. [3H]Glycerol-labeled diacylglycerol was largely derived directly from phosphatidic acid. Insulin increased de novo phosphatidic acid synthesis within 5 to 10 seconds; within 1 minute, this synthesis was 60 times greater than that of controls. Thus, the initial increase in diacylglycerol is due to both increased hydrolysis of phospholipids and a burst of de novo phosphatidic acid synthesis. After 5 to 10 minutes, de novo phosphatidic acid synthesis continues as a major source of diacylglycerol. Both phospholipid effects of insulin seem important for generating diacylglycerol and other phospholipid-derived intracellular signaling substances.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Farese, R V -- Konda, T S -- Davis, J S -- Standaert, M L -- Pollet, R J -- Cooper, D R -- AM18608/AM/NIADDK NIH HHS/ -- HD22248/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1987 May 1;236(4801):586-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3107122" target="_blank"〉PubMed〈/a〉
    Keywords: Arachidonic Acid ; Arachidonic Acids/metabolism ; Cell Line ; Diglycerides/*metabolism ; Enzyme Activation ; Glycerides/*metabolism ; Glycerol/metabolism ; Insulin/*pharmacology ; Kinetics ; Muscles/drug effects/*metabolism ; Phosphatidic Acids/*biosynthesis ; Phosphatidylinositols/metabolism ; Phospholipids/metabolism ; Type C Phospholipases/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Mitigation of hard x-ray background in backlit pinhole imagers (2016)
    American Institute of Physics (AIP)
    Details
    Publication Date: 2016-09-17
    Description: Experiments were performed to mitigate the hard x-ray background commonly observed in backlit pinhole imagers. The material of the scaffold holding the primary backlighter foil was varied to reduce the laser-plasma instabilities responsible for hot electrons and resulting hard x-ray background. Radiographic measurements with image plates showed a factor of 〉25 decrease in x-rays between 30 and 67 keV when going from a plastic to Al or V scaffold. A potential design using V scaffold offers a signal-to-background ratio of 6:1, a factor of 2 greater than using the bare plastic scaffold.
    Print ISSN: 0034-6748
    Electronic ISSN: 1089-7623
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Published by American Institute of Physics (AIP)
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  • 8
    Electronic Resource
    Electronic Resource
    Assembly Processes in Vertebrate Skeletal Thick Filament Formation (1988)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biophysics and Biomolecular Structure 17 (1988), S. 217-239 
    Details
    ISSN: 0084-6589
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.bb.17.060188.001245
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  • 9
    Electronic Resource
    Electronic Resource
    Secondary Radiations of Radium (1904)
    [s.l.] : Nature Publishing Group
    Nature 69 (1904), S. 489-489 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] I ENCLOSE two prints I have taken with a radium screen. No. 1 shows the impression of a steel pen-nib, a steel screw, and an ordinary paper fastener. These articles were laid on a photographic plate and exposed for 6 days. No. 2 shows the impression of two bronze coins (halfpennies) similarly ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/069489f0
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  • 10
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    Multi-fault analysis scorecard: testing the stochastic approach in fault seal prediction (2010)
    In:  Geological Society Special Publication 347: 317-332.
    Details
    Publication Date: 2010-11-08
    Description: Multi-fault analysis is an ExxonMobil stochastic tool for analysing the impact and sensitivities of stratigraphic uncertainty and variability on cross-fault leakage of hydrocarbons in faulted traps. This juxtaposition-based method provides quantitative prediction of hydrocarbon contact levels through a complex system of structural spills and juxtaposition leak points in traps with stacked reservoir systems and one or more faults. Validation of the Multi-fault analysis technology was carried out by comparing pre-drill predictions to post-drill results from 41 faulted exploration prospects drilled from 1994-2001. Of the 41 prospects, 29 were valid tests in which we made 22 successful predictions. Of the 22 successful outcomes, 11 were discoveries and 11 were dry wells. Some of the dry wells were drilled assuming the presence of sealing fault-zone material to trap hydrocarbons despite a Multi-fault analysis failure prediction. The seven Multi-fault failures comprise four predicted successes that were failures and three predicted failures that were successes. Most of the Multi-fault prediction failures can be attributed to data quality and uncertainty; however, some may be associated with sealing fault-zone material. Other considerations in fault seal analysis (i.e. dip leak along faults and sealing fault zone materials), model input uncertainties, and using drill-well learnings are also discussed.
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