Publication Date:
2012-01-28
Description:
The processes responsible for the evolution of key innovations, whereby lineages acquire qualitatively new functions that expand their ecological opportunities, remain poorly understood. We examined how a virus, bacteriophage lambda, evolved to infect its host, Escherichia coli, through a novel pathway. Natural selection promoted the fixation of mutations in the virus's host-recognition protein, J, that improved fitness on the original receptor, LamB, and set the stage for other mutations that allowed infection through a new receptor, OmpF. These viral mutations arose after the host evolved reduced expression of LamB, whereas certain other host mutations prevented the phage from evolving the new function. This study shows the complex interplay between genomic processes and ecological conditions that favor the emergence of evolutionary innovations.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306806/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306806/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meyer, Justin R -- Dobias, Devin T -- Weitz, Joshua S -- Barrick, Jeffrey E -- Quick, Ryan T -- Lenski, Richard E -- R00 GM087550/GM/NIGMS NIH HHS/ -- R00 GM087550-03/GM/NIGMS NIH HHS/ -- R00GM087550/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2012 Jan 27;335(6067):428-32. doi: 10.1126/science.1214449.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Zoology, Michigan State University, East Lansing, MI 48824, USA. justin.raymond.meyer@gmail.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22282803" target="_blank"〉PubMed〈/a〉
Keywords:
Alleles
;
Bacterial Outer Membrane Proteins/genetics/*metabolism
;
Bacteriophage lambda/*genetics/physiology
;
Escherichia coli/genetics/metabolism/*virology
;
*Evolution, Molecular
;
Genome, Bacterial
;
Genome, Viral
;
*Mutation
;
Polymorphism, Single Nucleotide
;
Porins/genetics/*metabolism
;
Receptors, Virus/genetics/*metabolism
;
Selection, Genetic
;
Viral Tail Proteins/chemistry/*genetics/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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