Publication Date:
2002-12-21
Description:
Members of the MyoD family of basic helix-loop-helix (bHLH) transcription factors control the formation of all skeletal muscles in vertebrates, but little is known of the molecules or mechanisms that confer unique identities to different types of skeletal muscles. MyoR and capsulin are related bHLH transcription factors expressed in specific facial muscle precursors. We show that specific facial muscles are missing in mice lacking both MyoR and capsulin, reflecting the absence of MyoD family gene expression and ablation of the corresponding myogenic lineages. These findings identify MyoR and capsulin as unique transcription factors for the development of specific head muscles.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lu, Jian-Rong -- Bassel-Duby, Rhonda -- Hawkins, April -- Chang, Priscilla -- Valdez, Renee -- Wu, Hai -- Gan, Lin -- Shelton, John M -- Richardson, James A -- Olson, Eric N -- New York, N.Y. -- Science. 2002 Dec 20;298(5602):2378-81.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, TX 75390-9148, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12493912" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Apoptosis
;
Basic Helix-Loop-Helix Transcription Factors
;
Branchial Region/embryology/metabolism
;
Cell Lineage
;
Cleft Palate/embryology
;
Crosses, Genetic
;
*DNA-Binding Proteins
;
Facial Muscles/cytology/*embryology/growth & development
;
Female
;
Gene Expression Regulation, Developmental
;
Gene Targeting
;
Head
;
Helix-Loop-Helix Motifs
;
Hernia, Diaphragmatic/embryology
;
Homozygote
;
In Situ Nick-End Labeling
;
Male
;
Masticatory Muscles/cytology/*embryology/growth & development
;
Mice
;
Muscle Cells/cytology/physiology
;
*Muscle Development
;
Muscle Proteins/genetics/metabolism
;
Muscle, Skeletal/embryology
;
Mutation
;
MyoD Protein/genetics/metabolism
;
Myogenic Regulatory Factor 5
;
Phenotype
;
*Trans-Activators
;
Transcription Factors/genetics/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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