Publication Date:
1989-07-28
Description:
Astrocytes have many neuronal characteristics, such as neurotransmitter receptors, ion channels, and neurotransmitter uptake systems. Cultured astrocytes were shown to express certain neuropeptide genes, with specificity for both the gene expressed and the brain region from which the cells were prepared. Somatostatin messenger RNA and peptides were detected only in cerebellar astrocytes, whereas proenkephalin messenger RNA and enkephalin peptides were present in astrocytes of cortex, cerebellum, and striatum. Cholecystokinin was not expressed in any of the cells. These results support the hypothesis that peptides synthesized in astrocytes may play a role in the development of the central nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shinoda, H -- Marini, A M -- Cosi, C -- Schwartz, J P -- New York, N.Y. -- Science. 1989 Jul 28;245(4916):415-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Clinical Neuroscience Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2569236" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Animals, Newborn
;
Astrocytes/*metabolism
;
Blotting, Northern
;
Cells, Cultured
;
Cerebellum/cytology/metabolism
;
Cerebral Cortex/cytology/metabolism
;
Corpus Striatum/cytology/metabolism
;
Enkephalin, Methionine/biosynthesis/genetics
;
Enkephalins/biosynthesis/genetics
;
*Gene Expression Regulation
;
Neuropeptides/biosynthesis/*genetics
;
Protein Precursors/biosynthesis/genetics
;
RNA, Messenger/analysis
;
Radioimmunoassay
;
Rats
;
Somatostatin/biosynthesis/genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink