Publication Date:
1981-07-31
Description:
The transplantable Leydig cell tumor of Wistar rats, LTW(m), caused decreased food consumption and weight loss in the host within 2 weeks of implantation. The tumor was small, did not metastasize, and did not affect several parameters of biochemical function. When the tumors were removed, increases in food intake and body weight occurred within 72 hours and were sustained. Reimplantation of tumors caused anorexia to recur. Parabiotic pairs of rats with tumor in one partner also experienced weight loss. Those rats in parabiosis with tumor-bearing rats gained less weight than those in parabiosis with control rats. These observations suggest that the LTW(m) tumor causes anorexia and that this anorexia is mediated by a circulating substance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mordes, J P -- Rossini, A A -- AM07302/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Jul 31;213(4507):565-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6941477" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Anorexia/*etiology
;
Body Weight
;
Feeding and Eating Disorders/*etiology
;
Humans
;
Leydig Cell Tumor/*complications
;
Male
;
Mammary Neoplasms, Experimental/complications
;
Neoplasms, Experimental/complications
;
Rats
;
Testicular Neoplasms/*complications
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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