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  • 1
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    tRNAs marked with CCACCA are targeted for degradation (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-11-15
    Description: The CCA-adding enzyme [ATP(CTP):tRNA nucleotidyltransferase] adds CCA to the 3' ends of transfer RNAs (tRNAs), a critical step in tRNA biogenesis that generates the amino acid attachment site. We found that the CCA-adding enzyme plays a key role in tRNA quality control by selectively marking structurally unstable tRNAs and tRNA-like small RNAs for degradation. Instead of adding CCA to the 3' ends of these transcripts, CCA-adding enzymes from all three kingdoms of life add CCACCA. In addition, hypomodified mature tRNAs are subjected to CCACCA addition as part of a rapid tRNA decay pathway in vivo. We conjecture that CCACCA addition is a universal mechanism for controlling tRNA levels and preventing errors in translation.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273417/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273417/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wilusz, Jeremy E -- Whipple, Joseph M -- Phizicky, Eric M -- Sharp, Phillip A -- 5T32-GM068411/GM/NIGMS NIH HHS/ -- P30 CA014051/CA/NCI NIH HHS/ -- P30 CA014051-38/CA/NCI NIH HHS/ -- P30-CA14051/CA/NCI NIH HHS/ -- R01 CA133404/CA/NCI NIH HHS/ -- R01 CA133404-05/CA/NCI NIH HHS/ -- R01 GM034277/GM/NIGMS NIH HHS/ -- R01 GM034277-28/GM/NIGMS NIH HHS/ -- R01 GM052347/GM/NIGMS NIH HHS/ -- R01 GM052347-16/GM/NIGMS NIH HHS/ -- R01-CA133404/CA/NCI NIH HHS/ -- R01-GM34277/GM/NIGMS NIH HHS/ -- R01-GM52347/GM/NIGMS NIH HHS/ -- T32 GM068411/GM/NIGMS NIH HHS/ -- T32 GM068411-08/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2011 Nov 11;334(6057):817-21. doi: 10.1126/science.1213671.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. wilusz@mit.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22076379" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Archaeal Proteins/metabolism ; Base Sequence ; Escherichia coli Proteins/metabolism ; Fungal Proteins/chemistry/metabolism ; Humans ; Mice ; Nucleic Acid Conformation ; Polyadenylation ; *RNA 3' End Processing ; RNA Nucleotidyltransferases/*metabolism ; *RNA Stability ; RNA, Fungal/chemistry/metabolism ; RNA, Transfer/chemistry/genetics/*metabolism ; RNA, Transfer, Ser/chemistry/metabolism ; RNA, Untranslated/chemistry/genetics/metabolism ; Saccharomyces cerevisiae/chemistry/genetics/metabolism ; Sulfolobus/enzymology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Along-strike variation in catchment morphology and cosmogenic denudation rates reveal the pattern and history of footwall uplift, Main Gulf Escarpment, Baja California (2017)
    Geological Society of America (GSA)
    Details
    Publication Date: 2017-07-01
    Description: Topography is expected to record tectonic, climatic, and rock strength controls on long-term denudation rates in active margins. We test this hypothesis in the Sierra San Pedro Mártir, Mexico—the footwall of the normal-faulted, western margin of the Gulf of California rift system—by relating topographic metrics with 10 Be-derived catchment-averaged denudation rates. Denudation rates and topographic metrics record along-strike gradients in rock uplift relative to base level that increase asymmetrically from fault tips to maxima within the northern half of the range. Surface uplift of an Eocene erosional surface and slope-break knickpoints found at increasingly higher elevations in the northern segments of the Sierra San Pedro Mártir fault system suggest that range asymmetry is due to a recent northward acceleration in the rate of rock uplift relative to base level. By characterizing the relationship between channel steepness and cosmogenic denudation rates, we extrapolate millennial-scale denudation rates to million-year time scales and estimate ages for the transient increase in rock uplift rates and the initial onset of normal faulting. We infer that the Sierra San Pedro Mártir fault system initiated during the middle Miocene (ca. 16–14 Ma) in the center of the range and ca. 12–8 Ma near the fault tips. Recent increases in rock uplift rates during the late Pliocene (ca. 3–2 Ma) coincide with lithospheric rupture in the Delfin basins to the east and represent a westward migration of strain from hanging-wall detachments to the Sierra San Pedro Mártir fault system. Age estimates are consistent with independent geologic constraints and show that pairing of carefully selected cosmogenic denudation rates with topographic analysis can be used to extract tectonic signals from topography over million-year time scales.
    Print ISSN: 0016-7606
    Electronic ISSN: 1943-2674
    Topics: Geosciences
    Published by Geological Society of America (GSA)
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  • 3
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    Management applications for thermal IR imagery of lake processes (1971)
    In:  CASI
    Details
    Publication Date: 2016-06-07
    Description: A thermal infrared scanning program was conducted in the Lake Ontario Basin region in an effort to determine: (1) limonologic data that could be collected by remote sensing techniques, and (2) local interest in and routine use of such data in water management programs. Difficulties encountered in the development of an infrared survey program in New York suggest that some of the major obstacles to acceptance of remotely sensed data for routine use are factors of psychology rather than technology. Also, terminology used should suit the measurement technique in order to encourage acceptance of the surface thermal data obtained.
    Keywords: GEOPHYSICS
    Type: NASA. Manned Spacecraft Center 3d Ann. Earth Resources Program Rev., Vol. 3 13p (SEE N72-12295 03-13
    Format: application/pdf
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