Publication Date:
2005-07-30
Description:
To study adaptation, it is essential to identify multiple adaptive mutations and to characterize their molecular, phenotypic, selective, and ecological consequences. Here we describe a genomic screen for adaptive insertions of transposable elements in Drosophila. Using a pilot application of this screen, we have identified an adaptive transposable element insertion, which truncates a gene and apparently generates a functional protein in the process. The insertion of this transposable element confers increased resistance to an organophosphate pesticide and has spread in D. melanogaster recently.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Aminetzach, Yael T -- Macpherson, J Michael -- Petrov, Dmitri A -- New York, N.Y. -- Science. 2005 Jul 29;309(5735):764-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Sciences, Stanford University, 371 Serra Mall, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16051794" target="_blank"〉PubMed〈/a〉
Keywords:
Adaptation, Physiological
;
Alleles
;
Amino Acid Substitution
;
Animals
;
Azinphosmethyl/pharmacology
;
Base Sequence
;
Choline/metabolism
;
Crosses, Genetic
;
*DNA Transposable Elements
;
Drosophila/drug effects/genetics/physiology
;
Drosophila Proteins/chemistry/*genetics/physiology
;
Drosophila melanogaster/drug effects/*genetics/physiology
;
*Evolution, Molecular
;
Exons
;
Female
;
Gene Expression
;
*Genes, Insect
;
Haplotypes
;
Insecticide Resistance/*genetics
;
Insecticides/pharmacology
;
Introns
;
Long Interspersed Nucleotide Elements
;
Molecular Sequence Data
;
Mutation
;
Polymorphism, Genetic
;
Recombination, Genetic
;
Selection, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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