Publication Date:
2003-03-22
Description:
Local circuits in the spinal cord that generate locomotion are termed central pattern generators (CPGs). These provide coordinated bilateral control over the normal limb alternation that underlies walking. The molecules that organize the mammalian CPG are unknown. Isolated spinal cords from mice lacking either the EphA4 receptor or its ligand ephrinB3 have lost left-right limb alternation and instead exhibit synchrony. We identified EphA4-positive neurons as an excitatory component of the locomotor CPG. Our study shows that dramatic locomotor changes can occur as a consequence of local genetic rewiring and identifies genes required for the development of normal locomotor behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kullander, Klas -- Butt, Simon J B -- Lebret, James M -- Lundfald, Line -- Restrepo, Carlos E -- Rydstrom, Anna -- Klein, Rudiger -- Kiehn, Ole -- New York, N.Y. -- Science. 2003 Mar 21;299(5614):1889-92.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medical Biochemistry, Gothenburg University, Medicinaregatan 9 A, 405 30 Gothenburg, Sweden. klas.kullander@medkem.gu.se〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12649481" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Axons/physiology
;
Bicuculline/pharmacology
;
Carrier Proteins/genetics/metabolism
;
Electrophysiology
;
Ephrin-B3/genetics/*physiology
;
Gait
;
In Vitro Techniques
;
Interneurons/physiology
;
*Membrane Transport Proteins
;
Mice
;
Mice, Inbred C57BL
;
Mice, Transgenic
;
Motor Activity
;
Neurons/*physiology
;
Nipecotic Acids/pharmacology
;
Receptor, EphA4/genetics/*physiology
;
Sarcosine/pharmacology
;
Signal Transduction
;
Spinal Cord/*physiology
;
Spinal Nerve Roots/physiology
;
Strychnine/pharmacology
;
Vesicular Glutamate Transport Protein 1
;
Vesicular Glutamate Transport Protein 2
;
*Vesicular Transport Proteins
;
*Walking
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
