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  • 1
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    Translation. An RNA biosensor for imaging the first round of translation from single cells to living animals (2015)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2015-03-21
    Description: Analysis of single molecules in living cells has provided quantitative insights into the kinetics of fundamental biological processes; however, the dynamics of messenger RNA (mRNA) translation have yet to be addressed. We have developed a fluorescence microscopy technique that reports on the first translation events of individual mRNA molecules. This allowed us to examine the spatiotemporal regulation of translation during normal growth and stress and during Drosophila oocyte development. We have shown that mRNAs are not translated in the nucleus but translate within minutes after export, that sequestration within P-bodies regulates translation, and that oskar mRNA is not translated until it reaches the posterior pole of the oocyte. This methodology provides a framework for studying initiation of protein synthesis on single mRNAs in living cells.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451088/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451088/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Halstead, James M -- Lionnet, Timothee -- Wilbertz, Johannes H -- Wippich, Frank -- Ephrussi, Anne -- Singer, Robert H -- Chao, Jeffrey A -- EB013571/EB/NIBIB NIH HHS/ -- GM57071/GM/NIGMS NIH HHS/ -- NS83085/NS/NINDS NIH HHS/ -- R01 EB013571/EB/NIBIB NIH HHS/ -- R01 GM057071/GM/NIGMS NIH HHS/ -- R01 NS083085/NS/NINDS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2015 Mar 20;347(6228):1367-671. doi: 10.1126/science.aaa3380.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Friedrich Miescher Institute for Biomedical Research, CH-4058 Basel, Switzerland. ; Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Transcription Imaging Consortium, Howard Hughes Medical Institute Janelia Farm Research Campus, Ashburn, VA 20147, USA. ; Friedrich Miescher Institute for Biomedical Research, CH-4058 Basel, Switzerland. University of Basel, CH-4003 Basel, Switzerland. ; Developmental Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany. ; Developmental Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany. ephrussi@embl.de robert.singer@einstein.yu.edu jeffrey.chao@fmi.ch. ; Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Transcription Imaging Consortium, Howard Hughes Medical Institute Janelia Farm Research Campus, Ashburn, VA 20147, USA. ephrussi@embl.de robert.singer@einstein.yu.edu jeffrey.chao@fmi.ch. ; Friedrich Miescher Institute for Biomedical Research, CH-4058 Basel, Switzerland. Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. ephrussi@embl.de robert.singer@einstein.yu.edu jeffrey.chao@fmi.ch.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25792328" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Transport ; *Biosensing Techniques ; Cell Nucleus/metabolism ; Cytosol/metabolism ; Drosophila Proteins/biosynthesis/genetics ; Drosophila melanogaster/cytology/growth & development/metabolism ; Microscopy, Fluorescence/methods ; Molecular Imaging/*methods ; Oocytes/growth & development/metabolism ; *Peptide Chain Initiation, Translational ; RNA, Messenger/*chemistry/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
    Electronic Resource
    Electronic Resource
    MANAGEMENT AND POLICY EFFECTS ON POTENTIAL GROUNDWATER CONTAMINATION FROM DAIRY WASTE (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the American Water Resources Association 26 (1990), S. 0 
    Details
    ISSN: 1752-1688
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Architecture, Civil Engineering, Surveying , Geography
    Notes: : A combined economic and water quality modeling framework was used to evaluate impacts of alternative policies and management practices on reducing nitrate movement to groundwater for dairy farms in Rockingham County, Virginia. The analysis considers three on-farm manure storage options, cost-sharing programs for purchasing manure storage facilities, restrictions on nitrogen application rates, and a tax on commercial fertilizer. The CREAMS model was used to estimate nitrate leaching from the crop root zone for various nutrient (and manure) management practices, based on timing and rate of manure and fertilizer applications. The mixed-integer programming economic model considers water quality, policy, and economic constraints in comparing the profitability of alternative cropping and nutrient management systems that reduce groundwater contamination potential. The study provides both the environmental and economic effects of better management of dairy waste.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1752-1688.1990.tb01347.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Socio-economic impact management: programme design and implementation considerations (1982)
    Springer
    Environmental geochemistry and health 4 (1982), S. 141-150 
    Details
    ISSN: 1573-2983
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Medicine
    Notes: Abstract While larger mineral resource development projects offer new jobs and provide a stimulus to the economy of the area where they are sited, they may also pose problems in rural areas associated with rapid population growth. The purpose of an impact management programme is to anticipate and alleviate project effects that are generally perceived as undesirable and to enhance effects that are beneficial to site area communities. While the effective management of project effects is the end towards which all impact assessment efforts are directed, an integrated approach to impact management has been notably lacking. This paper suggests a systems framework for meeting this need by: (1) reviewing the need for impact management efforts; (2) discussing the objectives of, and considerations in, designing impact management programmes; (3) presenting a conceptual framework for, and key components of, such a programme; and (4) suggesting an approach for implementing such a system as an integral part of the project development process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02085975
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  • 4
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    Socio-economic impact management: programme design and implementation considerations (1982)
    Springer
    Details
    Publication Date: 1982-12-01
    Print ISSN: 0269-4042
    Electronic ISSN: 1573-2983
    Topics: Geosciences , Medicine
    Published by Springer
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  • 5
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    MANAGEMENT AND POLICY EFFECTS ON POTENTIAL GROUNDWATER CONTAMINATION FROM DAIRY WASTE (1990)
    Wiley
    Details
    Publication Date: 1990-02-01
    Print ISSN: 1093-474X
    Electronic ISSN: 1752-1688
    Topics: Architecture, Civil Engineering, Surveying , Geography
    Published by Wiley
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