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  • 1
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    Inducing sleep by remote control facilitates memory consolidation in Drosophila (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-06-28
    Description: Sleep is believed to play an important role in memory consolidation. We induced sleep on demand by expressing the temperature-gated nonspecific cation channel Transient receptor potential cation channel (UAS-TrpA1) in neurons, including those with projections to the dorsal fan-shaped body (FB). When the temperature was raised to 31 degrees C, flies entered a quiescent state that meets the criteria for identifying sleep. When sleep was induced for 4 hours after a massed-training protocol for courtship conditioning that is not capable of inducing long-term memory (LTM) by itself, flies develop an LTM. Activating the dorsal FB in the absence of sleep did not result in the formation of LTM after massed training.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064462/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064462/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Donlea, Jeffrey M -- Thimgan, Matthew S -- Suzuki, Yasuko -- Gottschalk, Laura -- Shaw, Paul J -- 5F31NS063514-02/NS/NINDS NIH HHS/ -- NS057105/NS/NINDS NIH HHS/ -- R01 NS051305/NS/NINDS NIH HHS/ -- R01-NS051305-01A1/NS/NINDS NIH HHS/ -- T32GM008151/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2011 Jun 24;332(6037):1571-6. doi: 10.1126/science.1202249.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anatomy and Neurobiology, Washington University in St. Louis, St. Louis, MO 63110, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21700877" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Conditioning (Psychology) ; Drosophila/genetics/*physiology ; Drosophila Proteins/genetics/metabolism ; Female ; Memory, Long-Term/*physiology ; Models, Animal ; Motor Activity ; Neurons/*physiology ; Presynaptic Terminals/physiology ; Sleep/*physiology ; Social Isolation ; Temperature ; Transcription Factors/genetics/metabolism ; Transient Receptor Potential Channels/genetics/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Use-dependent plasticity in clock neurons regulates sleep need in Drosophila (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-04-04
    Description: Sleep is important for memory consolidation and is responsive to waking experience. Clock circuitry is uniquely positioned to coordinate interactions between processes underlying memory and sleep need. Flies increase sleep both after exposure to an enriched social environment and after protocols that induce long-term memory. We found that flies mutant for rutabaga, period, and blistered were deficient for experience-dependent increases in sleep. Rescue of each of these genes within the ventral lateral neurons (LNVs) restores increased sleep after social enrichment. Social experiences that induce increased sleep were associated with an increase in the number of synaptic terminals in the LNV projections into the medulla. The number of synaptic terminals was reduced during sleep and this decline was prevented by sleep deprivation.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850598/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850598/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Donlea, Jeffrey M -- Ramanan, Narendrakumar -- Shaw, Paul J -- F31 NS063514-01A1/NS/NINDS NIH HHS/ -- R01-NS051305-01A1/NS/NINDS NIH HHS/ -- T32-GM008151/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2009 Apr 3;324(5923):105-8. doi: 10.1126/science.1166657.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anatomy and Neurobiology, Washington University in St. Louis, 660 South Euclid Avenue, St. Louis, Missouri, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19342592" target="_blank"〉PubMed〈/a〉
    Keywords: Adenylyl Cyclases/genetics/physiology ; Animals ; Biological Clocks/genetics ; Brain/physiology ; Circadian Rhythm/genetics ; Drosophila Proteins/genetics/metabolism/physiology ; Drosophila melanogaster/cytology/genetics/*physiology ; Female ; Genes, Insect ; Male ; Memory ; Models, Animal ; Mutation ; *Neuronal Plasticity ; Neurons/*physiology/ultrastructure ; Nuclear Proteins/genetics/physiology ; Period Circadian Proteins ; Presynaptic Terminals/physiology/ultrastructure ; Receptor, Epidermal Growth Factor/genetics/metabolism ; Receptors, Invertebrate Peptide/genetics/metabolism ; Serum Response Factor/genetics/physiology ; Sleep/*physiology ; Sleep Deprivation ; Social Behavior ; Synapses/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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    PAPER CURRENT
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