Publication Date:
1997-12-31
Description:
Virus-specific CD4+ T helper lymphocytes are critical to the maintenance of effective immunity in a number of chronic viral infections, but are characteristically undetectable in chronic human immunodeficiency virus-type 1 (HIV-1) infection. In individuals who control viremia in the absence of antiviral therapy, polyclonal, persistent, and vigorous HIV-1-specific CD4+ T cell proliferative responses were present, resulting in the elaboration of interferon-gamma and antiviral beta chemokines. In persons with chronic infection, HIV-1-specific proliferative responses to p24 were inversely related to viral load. Strong HIV-1-specific proliferative responses were also detected following treatment of acutely infected persons with potent antiviral therapy. The HIV-1-specific helper cells are likely to be important in immunotherapeutic interventions and vaccine development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rosenberg, E S -- Billingsley, J M -- Caliendo, A M -- Boswell, S L -- Sax, P E -- Kalams, S A -- Walker, B D -- F32-AI09738/AI/NIAID NIH HHS/ -- R01-A136550/PHS HHS/ -- R01-AI28568/AI/NIAID NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1997 Nov 21;278(5342):1447-50.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9367954" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Anti-HIV Agents/therapeutic use
;
Chemokines/biosynthesis
;
Cohort Studies
;
Cytotoxicity, Immunologic
;
Disease Progression
;
Drug Therapy, Combination
;
HIV Core Protein p24/immunology
;
HIV Envelope Protein gp160/immunology
;
HIV Infections/drug therapy/*immunology/*virology
;
HIV-1/*immunology/physiology
;
Humans
;
Immunologic Memory
;
Interferon-gamma/biosynthesis
;
Lymphocyte Activation
;
Molecular Sequence Data
;
Peptide Fragments/immunology
;
T-Lymphocytes, Cytotoxic/immunology
;
T-Lymphocytes, Helper-Inducer/*immunology
;
Viral Load
;
Viremia/*immunology/virology
;
Virus Replication
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
