Publication Date:
1982-04-02
Description:
The respiratory tract epithelium of dogs, from the nose to the lungs, was examined for cytochrome P-450 and associated biotransformation activities. In the ethmoturbinates, where olfactory epithelium is located, the amount of cytochrome P-450 was comparable to that in the liver, when measured on the basis of activity per milligram of microsomal protein. The rest of the nasal region also contained large quantities of cytochrome P-450. The presence of these enzymes in the nose may be important in chemical-induced tumorigenesis. The nasal carcinogen hexamethyl-phosphoramide was shown to be metabolized by nasal microsomal enzymes to another nasal carcinogen, formaldehyde.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dahl, A R -- Hadley, W M -- Hahn, F F -- Benson, J M -- McClellan, R O -- DE-AC04-76EUO1013/DE/NIDCR NIH HHS/ -- New York, N.Y. -- Science. 1982 Apr 2;216(4541):57-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7063870" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
*Biotransformation
;
Cytochrome P-450 Enzyme System
;
Dogs
;
Liver/enzymology
;
Lung/enzymology
;
Microsomes/enzymology
;
Nasal Mucosa/*enzymology
;
Neoplasms/chemically induced
;
Oxygenases/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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