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  • 1
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    Cocaine potently blocks neuronal α3β4 nicotinic acetylcholine receptors in SH-SY5Y cells (2019)
    Springer Nature
    Details
    Publication Date: 2019
    Print ISSN: 1671-4083
    Electronic ISSN: 1745-7254
    Topics: Chemistry and Pharmacology , Medicine
    Published by Springer Nature
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  • 2
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    Insights into the Structural Determinants Required for High-Affinity Binding of Chiral Cyclopropane-Containing Ligands to α4β2-Nicotinic Acetylcholine Receptors: An Integrated Approach to Behaviorally Active Nicotinic Ligands (2012)
    American Chemical Society (ACS)
    Details
    Publication Date: 2012-09-08
    Description: Journal of Medicinal Chemistry DOI: 10.1021/jm3008739
    Topics: Chemistry and Pharmacology
    Published by American Chemical Society (ACS)
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  • 3
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    Rapid destruction of human Cdc25A in response to DNA damage (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-05-29
    Description: To protect genome integrity and ensure survival, eukaryotic cells exposed to genotoxic stress cease proliferating to provide time for DNA repair. Human cells responded to ultraviolet light or ionizing radiation by rapid, ubiquitin- and proteasome-dependent protein degradation of Cdc25A, a phosphatase that is required for progression from G1 to S phase of the cell cycle. This response involved activated Chk1 protein kinase but not the p53 pathway, and the persisting inhibitory tyrosine phosphorylation of Cdk2 blocked entry into S phase and DNA replication. Overexpression of Cdc25A bypassed this mechanism, leading to enhanced DNA damage and decreased cell survival. These results identify specific degradation of Cdc25A as part of the DNA damage checkpoint mechanism and suggest how Cdc25A overexpression in human cancers might contribute to tumorigenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mailand, N -- Falck, J -- Lukas, C -- Syljuasen, R G -- Welcker, M -- Bartek, J -- Lukas, J -- New York, N.Y. -- Science. 2000 May 26;288(5470):1425-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen, Denmark.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10827953" target="_blank"〉PubMed〈/a〉
    Keywords: *CDC2-CDC28 Kinases ; Cell Line ; Cell Survival ; Cyclin E/metabolism ; Cyclin-Dependent Kinase 2 ; Cyclin-Dependent Kinases/antagonists & inhibitors/metabolism ; Cysteine Endopeptidases/metabolism ; *DNA Damage ; DNA Repair ; DNA Replication ; G1 Phase ; Humans ; Multienzyme Complexes/metabolism ; Phosphorylation ; Phosphotyrosine/metabolism ; Proteasome Endopeptidase Complex ; Protein Kinase Inhibitors ; Protein Kinases/metabolism ; Protein-Serine-Threonine Kinases/antagonists & inhibitors/metabolism ; Recombinant Fusion Proteins/metabolism ; S Phase ; Transfection ; Tumor Cells, Cultured ; Tumor Suppressor Protein p53/metabolism ; Ultraviolet Rays ; cdc25 Phosphatases/genetics/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Cell cycle. Order from destruction (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-10-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bartek, J -- Lukas, J -- New York, N.Y. -- Science. 2001 Oct 5;294(5540):66-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Cancer Biology, Danish Cancer Society, DK-2100 Copenhagen, Denmark. bartek@biobase.dk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11588240" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Breast Neoplasms/genetics ; *CDC2-CDC28 Kinases ; *Cell Cycle ; Cell Cycle Proteins/genetics/*metabolism ; Cell Membrane/metabolism ; Cell Nucleus/metabolism ; Cyclin E/genetics/*metabolism ; Cyclin-Dependent Kinase 2 ; Cyclin-Dependent Kinases/*metabolism ; Cysteine Endopeptidases/metabolism ; *F-Box Proteins ; Female ; Gene Expression ; Humans ; Multienzyme Complexes/metabolism ; Mutation ; Neoplasms/etiology ; Ovarian Neoplasms/genetics ; Peptide Synthases/*metabolism ; Phosphorylation ; Proteasome Endopeptidase Complex ; Protein-Serine-Threonine Kinases/*metabolism ; SKP Cullin F-Box Protein Ligases ; *Ubiquitin-Protein Ligases ; Ubiquitins/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    DNA repair: New tales of an old tail (2009)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2009-04-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lukas, Jiri -- Bartek, Jiri -- England -- Nature. 2009 Apr 2;458(7238):581-3. doi: 10.1038/458581a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19340068" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Apoptosis ; Cell Survival ; Chromatin Assembly and Disassembly ; DNA Damage ; *DNA Repair ; DNA-Binding Proteins/deficiency/genetics/metabolism ; Histones/genetics/*metabolism ; Humans ; Intracellular Signaling Peptides and Proteins/deficiency/genetics/metabolism ; Nuclear Proteins/deficiency/genetics/metabolism ; Phosphorylation ; Phosphotyrosine/metabolism ; Protein Tyrosine Phosphatases/deficiency/genetics/metabolism ; Tyrosine/*metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 6
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    Cell biology. Balancing life-or-death decisions (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-10-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bartek, Jiri -- Lukas, Jiri -- New York, N.Y. -- Science. 2006 Oct 13;314(5797):261-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen, Denmark. jb@cancer.dk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17038611" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Apoptosis ; BRCA2 Protein/metabolism ; Cell Cycle ; Cell Nucleus/metabolism ; Cell Survival ; Cyclin-Dependent Kinase 2/antagonists & inhibitors/*metabolism ; *DNA Damage ; DNA Repair ; DNA Replication ; Forkhead Transcription Factors/*metabolism ; Gene Expression Regulation ; Humans ; Mice ; Models, Biological ; Phosphorylation ; RNA, Small Interfering ; Transcription, Genetic ; cdc25 Phosphatases/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    DNA repair: Cyclin D1 multitasks (2011)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2011-06-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bartek, Jiri -- Lukas, Jiri -- England -- Nature. 2011 Jun 8;474(7350):171-2. doi: 10.1038/474171a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21654798" target="_blank"〉PubMed〈/a〉
    Keywords: Cyclin D1/deficiency/*metabolism ; DNA Damage/radiation effects ; DNA Repair/*physiology/radiation effects ; Humans ; Neoplasms/genetics/*metabolism/pathology ; Protein Binding/radiation effects ; Protein Interaction Mapping ; Rad51 Recombinase/metabolism ; Recombination, Genetic/genetics ; Retinoblastoma Protein/deficiency
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 8
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    Cell biology. The stress of finding NEMO (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-02-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bartek, Jiri -- Lukas, Jiri -- New York, N.Y. -- Science. 2006 Feb 24;311(5764):1110-1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen, Denmark. jb@cancer.dk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16497923" target="_blank"〉PubMed〈/a〉
    Keywords: Active Transport, Cell Nucleus ; Ataxia Telangiectasia Mutated Proteins ; Cell Cycle Proteins/*metabolism ; Cell Death ; Cell Nucleus/metabolism ; Cell Survival ; Cytoplasm/metabolism ; *DNA Damage ; DNA Repair ; DNA-Binding Proteins/*metabolism ; Gene Expression Regulation ; Humans ; I-kappa B Kinase/*metabolism ; Models, Biological ; NF-kappa B/metabolism ; Neoplasms/pathology/physiopathology ; Protein-Serine-Threonine Kinases/*metabolism ; SUMO-1 Protein/metabolism ; Signal Transduction ; Tumor Suppressor Proteins/*metabolism ; Ubiquitin/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    Regulation of replication fork progression through histone supply and demand (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2007-12-22
    Description: DNA replication in eukaryotes requires nucleosome disruption ahead of the replication fork and reassembly behind. An unresolved issue concerns how histone dynamics are coordinated with fork progression to maintain chromosomal stability. Here, we characterize a complex in which the human histone chaperone Asf1 and MCM2-7, the putative replicative helicase, are connected through a histone H3-H4 bridge. Depletion of Asf1 by RNA interference impedes DNA unwinding at replication sites, and similar defects arise from overproduction of new histone H3-H4 that compromises Asf1 function. These data link Asf1 chaperone function, histone supply, and replicative unwinding of DNA in chromatin. We propose that Asf1, as a histone acceptor and donor, handles parental and new histones at the replication fork via an Asf1-(H3-H4)-MCM2-7 intermediate and thus provides a means to fine-tune replication fork progression and histone supply and demand.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Groth, Anja -- Corpet, Armelle -- Cook, Adam J L -- Roche, Daniele -- Bartek, Jiri -- Lukas, Jiri -- Almouzni, Genevieve -- New York, N.Y. -- Science. 2007 Dec 21;318(5858):1928-31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Nuclear Dynamics and Genome Plasticity, UMR218 CNRS/Institut Curie, 26 rue d'Ulm, 75248 Paris cedex 05, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18096807" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Cycle Proteins/genetics/*metabolism ; Chromatin/metabolism ; DNA/*metabolism ; *DNA Replication ; DNA, Single-Stranded/metabolism ; HeLa Cells ; Histones/*metabolism ; Humans ; Minichromosome Maintenance Complex Component 2 ; Models, Biological ; Molecular Chaperones/genetics/metabolism ; Nuclear Proteins/metabolism ; Nucleosomes/metabolism ; RNA Interference ; S Phase
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    Molecular biology. Shielding broken DNA for a quick fix (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-02-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lukas, Jiri -- Lukas, Claudia -- New York, N.Y. -- Science. 2013 Feb 8;339(6120):652-3. doi: 10.1126/science.1234602.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3b, 2200 Copenhagen, Denmark. jiri.lukas@cpr.ku.dk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23393250" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromosomal Proteins, Non-Histone/*metabolism ; DNA/*metabolism ; *DNA Breaks, Double-Stranded ; *DNA Repair ; DNA-Binding Proteins/*metabolism ; *Immunoglobulin Class Switching ; Telomere/*metabolism ; Telomere-Binding Proteins/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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