Publication Date:
2010-04-03
Description:
The MADS-domain transcription factor APETALA1 (AP1) is a key regulator of Arabidopsis flower development. To understand the molecular mechanisms underlying AP1 function, we identified its target genes during floral initiation using a combination of gene expression profiling and genome-wide binding studies. Many of its targets encode transcriptional regulators, including known floral repressors. The latter genes are down-regulated by AP1, suggesting that it initiates floral development by abrogating the inhibitory effects of these genes. Although AP1 acts predominantly as a transcriptional repressor during the earliest stages of flower development, at more advanced stages it also activates regulatory genes required for floral organ formation, indicating a dynamic mode of action. Our results further imply that AP1 orchestrates floral initiation by integrating growth, patterning, and hormonal pathways.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaufmann, Kerstin -- Wellmer, Frank -- Muino, Jose M -- Ferrier, Thilia -- Wuest, Samuel E -- Kumar, Vijaya -- Serrano-Mislata, Antonio -- Madueno, Francisco -- Krajewski, Pawel -- Meyerowitz, Elliot M -- Angenent, Gerco C -- Riechmann, Jose Luis -- New York, N.Y. -- Science. 2010 Apr 2;328(5974):85-9. doi: 10.1126/science.1185244.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Business Unit Bioscience, Plant Research International, Wageningen 6700 AA, Netherlands.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20360106" target="_blank"〉PubMed〈/a〉
Keywords:
Arabidopsis/*genetics/*growth & development/metabolism
;
Arabidopsis Proteins/genetics/*metabolism
;
Binding Sites
;
Chromatin Immunoprecipitation
;
Down-Regulation
;
Flowers/*growth & development
;
Gene Expression Profiling
;
*Gene Expression Regulation, Plant
;
Genes, Plant
;
Genome, Plant
;
Homeodomain Proteins/genetics/metabolism
;
MADS Domain Proteins/genetics/*metabolism
;
Oligonucleotide Array Sequence Analysis
;
Transcription Factors/genetics/*metabolism
;
Transcription Initiation Site
;
*Transcription, Genetic
;
Transcriptional Activation
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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