Publication Date:
1995-06-30
Description:
In normal Drosophila melanogaster oocytes, meiosis arrests at metaphase I and resumes after oocyte passage through the oviduct. Thus, metaphase arrest defines a control point in the meiotic cell cycle. Metaphase arrest only occurs in oocytes that have undergone at least one meiotic exchange. Here it is shown that crossovers between homologs attached to the same centromere do not induce metaphase arrest. Hence, exchanges induce metaphase arrest only when they physically conjoin two separate kinetochores. Thus, the signal that mediates metaphase arrest is not the exchange event per se but the resulting tension on homologous kinetochores.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jang, J K -- Messina, L -- Erdman, M B -- Arbel, T -- Hawley, R S -- N01-HD-2-3144/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1995 Jun 30;268(5219):1917-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics, University of California at Davis 95616, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7604267" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Crossing Over, Genetic
;
Drosophila melanogaster
;
Female
;
Kinetochores/*physiology
;
*Meiosis
;
*Metaphase
;
Oocytes/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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