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  • 1
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    Structure and 40Ar/39Ar thermochronology of an ultrahigh-pressure transition in western Norway (2011)
    Geological Society of London
    Details
    Publication Date: 2011-06-16
    Description: : The Nordfjord region of western Norway hosts an archetypal subducted crustal section, underpinned by ultrahigh-pressure (UHP) eclogite, overlain by Devonian sediments, and cored by a crustal-scale extensional shear zone. Structural mapping reveals two distinct displacement zones that played different roles during the formation and exhumation of this section: (1) the Sandane Shear Zone is a NW-dipping, amphibolite-facies, high-strain zone near the base of the eclogite-bearing crust that separates allochthonous units from underlying crystalline basement; it may have originated during early thrusting, but was overprinted by top-to-the-west extensional fabrics at lower crustal depths; (2) structurally above this, the Nordfjord–Sogn Detachment Zone is a top-to-the-west, amphibolite- to greenschist-facies detachment shear zone within allochthonous units that defines the upper boundary of the eclogitized crust and was responsible for exhumation through at least mid-crustal depths. Muscovite 40 Ar/ 39 Ar ages suggest that amphibolite-facies deformation below the Nordfjord–Sogn Detachment was mostly finished by c . 397 Ma, whereas muscovite ages from the deeper parts of the UHP domain indicate that it cooled after 390 Ma. During exhumation through the middle crust, west-directed stretching was accompanied by north–south folding. Late sinistral transpressional faulting in the middle to upper crust truncated the earlier folds and shear zones. Supplementary material: Complete 40 Ar/ 39 Ar data and a summary geological map of the Nordfjord region are available at http://www.geolsoc.org.uk/SUP18460 .
    Print ISSN: 0016-7649
    Topics: Geosciences
    Published by Geological Society of London
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  • 2
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    Inferring the oriented elastic tensor from surface wave observations: preliminary application across the western United States (2015)
    Oxford University Press
    Details
    Publication Date: 2015-03-26
    Description: Radial and azimuthal anisotropy in seismic wave speeds have long been observed using surface waves and are believed to be controlled by deformation within the Earth's crust and uppermost mantle. Although radial and azimuthal anisotropy reflect important aspects of anisotropic media, few studies have tried to interpret them jointly. We describe a method of inversion that interprets simultaneous observations of radial and azimuthal anisotropy under the assumption of a hexagonally symmetric elastic tensor with a tilted symmetry axis defined by dip and strike angles. We show that observations of radial anisotropy and the 2 component of azimuthal anisotropy for Rayleigh waves obtained using USArray data in the western United States can be fit well under this assumption. Our inferences occur within the framework of a Bayesian Monte Carlo inversion, which yields a posterior distribution that reflects both variances of and covariances between all model variables, and divide into theoretical and observational results. Principal theoretical results include the following: (1) There are two distinct groups of models (Group 1, Group 2) in the posterior distribution in which the strike angle of anisotropy in the crust (defined by the intersection of the foliation plane with Earth's surface) is approximately orthogonal between the two sets. (2) The Rayleigh wave fast axis directions are orthogonal to the strike angle in the geologically preferred group of models in which anisotropy is strongly non-elliptical. (3) The estimated dip angle may be interpreted in two ways: as a measure of the actual dip of the foliation of anisotropic material within the crust, or as a proxy for another non-geometric variable, most likely a measure of the deviation from hexagonal symmetry of the medium. The principal observational results include the following: (1) Inherent S -wave anisotropy ( ) is fairly homogeneous vertically across the crust, on average, and spatially across the western United States. (2) Averaging over the region of study and in depth, in the crust is approximately 4.1 ± 2 per cent. in the crust is approximately the same in the two groups of models. (3) Dip angles in the two groups of models show similar spatial variability and display geological coherence. (4) Tilting the symmetry axis of an anisotropic medium produces apparent radial and apparent azimuthal anisotropies that are both smaller in amplitude than the inherent anisotropy of the medium, which means that most previous studies have probably underestimated the strength of anisotropy.
    Keywords: Seismology
    Print ISSN: 0956-540X
    Electronic ISSN: 1365-246X
    Topics: Geosciences
    Published by Oxford University Press on behalf of The Deutsche Geophysikalische Gesellschaft (DGG) and the Royal Astronomical Society (RAS).
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  • 3
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    Himalayan gneiss dome formation in the middle crust and exhumation by normal faulting: New geochronology of Gianbul dome, northwestern India (2014)
    Geological Society of America (GSA)
    Details
    Publication Date: 2014-12-31
    Description: A general lack of consensus about the origin of Himalayan gneiss domes hinders accurate thermomechanical modeling of the orogen. To test whether doming resulted from tectonic contraction (e.g., thrust duplex formation, antiformal bending above a thrust ramp, etc.), channel flow, or via the buoyant rise of anatectic melts, this study investigates the depth and timing of doming processes for Gianbul dome in the western Himalaya. The dome is composed of Greater Himalayan Sequence migmatite, Paleozoic orthogneiss, and metasedimentary rock cut by multiple generations of leucogranite dikes. These rocks record a major penetrative D2 deformational event characterized by a domed foliation and associated NE-SW–trending stretching lineation, and they are flanked by the top-down-to-the-SW (normal-sense) Khanjar shear zone and the top-down-to-the-NE (normal sense) Zanskar shear zone (the western equivalent of the South Tibetan detachment system). Monazite U/Th-Pb geochronology records (1) Paleozoic emplacement of the Kade orthogneiss and associated granite dikes; (2) prograde Barrovian metamorphism from 37 to 33 Ma; (3) doming driven by upper-crustal extension and positive buoyancy of decompression melts between 26 and 22 Ma; and (4) the injection of anatectic melts into the upper levels of the dome—neutralizing the effects of melt buoyancy and potentially adding strength to the host rock—by ca. 22.6 Ma on the southwestern flank and ca. 21 Ma on the northeastern flank. As shown by a northeastward decrease in 40 Ar/ 39 Ar muscovite dates from 22.4 to 20.2 Ma, ductile normal-sense displacement within the Zanskar shear zone ended by ca. 22 Ma, after which the Gianbul dome was exhumed as part of a rigid footwall block below the brittle Zanskar normal fault, tilting an estimated 5°–10°SW into its present orientation.
    Print ISSN: 0016-7606
    Electronic ISSN: 1943-2674
    Topics: Geosciences
    Published by Geological Society of America (GSA)
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  • 4
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    Escherichia coli induces DNA double-strand breaks in eukaryotic cells (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-08-12
    Description: Transient infection of eukaryotic cells with commensal and extraintestinal pathogenic Escherichia coli of phylogenetic group B2 blocks mitosis and induces megalocytosis. This trait is linked to a widely spread genomic island that encodes giant modular nonribosomal peptide and polyketide synthases. Contact with E. coli expressing this gene cluster causes DNA double-strand breaks and activation of the DNA damage checkpoint pathway, leading to cell cycle arrest and eventually to cell death. Discovery of hybrid peptide-polyketide genotoxins in E. coli will change our view on pathogenesis and commensalism and open new biotechnological applications.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nougayrede, Jean-Philippe -- Homburg, Stefan -- Taieb, Frederic -- Boury, Michele -- Brzuszkiewicz, Elzbieta -- Gottschalk, Gerhard -- Buchrieser, Carmen -- Hacker, Jorg -- Dobrindt, Ulrich -- Oswald, Eric -- New York, N.Y. -- Science. 2006 Aug 11;313(5788):848-51.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉INRA, UMR1225, Ecole Nationale Veterinaire de Toulouse, Toulouse F-31076, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16902142" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ataxia Telangiectasia Mutated Proteins ; Cell Cycle ; Cell Cycle Proteins/metabolism ; Cell Death ; Cell Line ; Cell Nucleus/chemistry ; Cytotoxins/*metabolism ; DNA/analysis ; *DNA Damage ; DNA-Binding Proteins/metabolism ; Escherichia coli/genetics/*pathogenicity/*physiology ; G2 Phase ; *Genomic Islands ; HeLa Cells ; Histones/metabolism ; Humans ; Intestinal Mucosa/cytology/microbiology ; Molecular Sequence Data ; Mutagenesis ; Mutagens/*metabolism ; Peptides/*metabolism ; Phosphorylation ; Polyketide Synthases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; Rats ; Signal Transduction ; Tumor Suppressor Proteins/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Inhibition of hepatitis B virus replication by drug-induced depletion of nucleocapsids (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-02-08
    Description: Chronic hepatitis B virus (HBV) infection is a major cause of liver disease. Only interferon-alpha and the nucleosidic inhibitors of the viral polymerase, 3TC and adefovir, are approved for therapy. However, these therapies are limited by the side effects of interferon and the substantial resistance of the virus to nucleosidic inhibitors. Potent new antiviral compounds suitable for monotherapy or combination therapy are highly desired. We describe non-nucleosidic inhibitors of HBV nucleocapsid maturation that possess in vitro and in vivo antiviral activity. These inhibitors have potential for future therapeutic regimens to combat chronic HBV infection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Deres, Karl -- Schroder, Claus H -- Paessens, Arnold -- Goldmann, Siegfried -- Hacker, Hans Jorg -- Weber, Olaf -- Kramer, Thomas -- Niewohner, Ulrich -- Pleiss, Ulrich -- Stoltefuss, Jurgen -- Graef, Erwin -- Koletzki, Diana -- Masantschek, Ralf N A -- Reimann, Anja -- Jaeger, Rainer -- Gross, Rainer -- Beckermann, Bernhard -- Schlemmer, Karl-Heinz -- Haebich, Dieter -- Rubsamen-Waigmann, Helga -- New York, N.Y. -- Science. 2003 Feb 7;299(5608):893-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Virology, Chemistry, Isotope Chemistry, Preclinical Pharmakokinetics, Toxicology, Safety Pharmacology, Bayer Research Center, Wuppertal, Germany. karl.deres.kd1@bayer-ag.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12574631" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcysteine/*analogs & derivatives/pharmacology ; Amino Acid Substitution ; Antiviral Agents/chemistry/metabolism/*pharmacology ; Binding Sites ; Capsid/metabolism ; DNA Replication/drug effects ; DNA, Viral/biosynthesis ; Half-Life ; Hepatitis B Virus, Duck/drug effects/metabolism ; Hepatitis B virus/*drug effects/physiology ; Humans ; Mutation ; Nucleocapsid/*metabolism ; Pyridines/chemistry/metabolism/*pharmacology ; Pyrimidines/chemistry/metabolism/*pharmacology ; Recombinant Proteins/metabolism ; Stereoisomerism ; Triazoles/chemistry/metabolism/*pharmacology ; Tumor Cells, Cultured ; Viral Core Proteins/chemistry/genetics/metabolism ; Virus Assembly/drug effects ; Virus Replication/drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Prokaryotic chromosomes and disease (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-08-09
    Description: Recent insights into bacterial genome organization and function have improved our understanding of the nature of pathogenic bacteria and their ability to cause disease. It is becoming increasingly clear that the bacterial chromosome constantly undergoes structural changes due to gene acquisition and loss, recombination, and mutational events that have an impact on the pathogenic potential of the bacterium. Even though the bacterial genome includes additional genetic elements, the chromosome represents the most important entity in this context. Here, we will show that various processes of genomic instability have an influence on the many manifestations of infectious disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hacker, Jorg -- Hentschel, Ute -- Dobrindt, Ulrich -- New York, N.Y. -- Science. 2003 Aug 8;301(5634):790-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut fur Molekulare Infektionsbiologie, Universitat Wurzburg, Rontgenring 11, 97070 Wurzburg, Germany. j.hacker@mail.uni-wuerzburg.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12907788" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological ; Animals ; Bacteria/*genetics/*pathogenicity ; Bacterial Infections/*microbiology ; Chromosomes, Bacterial/genetics/*physiology ; Drug Resistance, Bacterial/genetics ; Evolution, Molecular ; Gene Transfer, Horizontal ; Genes, Bacterial ; Genome, Bacterial ; Humans ; Interspersed Repetitive Sequences ; Mutation ; Recombination, Genetic ; Symbiosis ; Virulence/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
    Electronic Resource
    Electronic Resource
    Confirmation of the existence of a third family among peptidyl-prolyl cis/trans isomerases Amino acid sequence and recombinant production of parvulin
    Amsterdam : Elsevier
    FEBS Letters 352 (1994), S. 180-184 
    Details
    ISSN: 0014-5793
    Keywords: Amino acid sequence ; Escherichia coli ; Parvulin ; Peptidyl-prolyl cis/trans isomerase ; Sequence homology
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(94)00932-5
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  • 8
    Electronic Resource
    Electronic Resource
    A homodimer represents an active species of the peptidyl-prolyl cis/trans isomerase FKBP25mem from Legionella pneumophila
    Amsterdam : Elsevier
    FEBS Letters 352 (1994), S. 185-190 
    Details
    ISSN: 0014-5793
    Keywords: Enzyme kinetics ; FK506-binding protein ; Legionella pneumophila ; Mip protein ; Oligomerization ; Peptidyl-prolyl cis/trans isomerase ; Virulence factor
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(94)00970-8
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  • 9
    Electronic Resource
    Electronic Resource
    Yersinia HPI in septicemic Escherichia coli strains isolated from diverse hosts (2001)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 196 (2001), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: High pathogenicity islands (HPIs), first identified in various Yersinia species, encode an iron uptake system. We have studied the occurrence of HPIs in septicemic strains of Escherichia coli isolated from a variety of hosts. The results presented in this communication indicate that most septicemic strains tested contained HPI sequences even though they already have the aerobactin encoding genes. We have also observed two types of HPI deletions, suggesting genetic instability of this element. Notable exceptions are several strains isolated from septicemia in sheep that lacked both iron acquisition systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6968.2001.tb10540.x
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  • 10
    Electronic Resource
    Electronic Resource
    Characterization of legiolysin (lly), responsible for haemolytic activity, colour production and fluorescence of Legionella pneumophila (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Molecular microbiology 5 (1991), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: A genomic library of Legionella pneumophila, the causative agent of Legionnaires’disease in humans was constructed in Escherichia coli K12 and the recombinant clones were tested for haemolysis and other phenotypic properties. Seven clones were identified which were able to confer haemolysis of human, sheep, and canine erythrocytes but which were unable to mediate proteolytic activities or cyto-toxic effects on CHO- or Vero cells. Clones that exhibited this haemolytic property were also able to produce a brown colour and a yellow-green fluorescence activity detected on M9 plates containing tyrosine. The genetic determinant encoding these properties, termed legiolysin (lly) was mapped by Tn 1000 mutagenesis and by subcloning experiments. Southern hybridization with an lly-specific gene probe showed that this determinant is part of the genome of L. pneumophila but is not identical to a protease gene of L. pneumophila which also mediates haemolysis. Minicell analysis of lly-specific plasmids exhibited a protein of 39kDa. Polyclonal antibodies generated against a LacZ-Lly hybrid protein also recognized a 39kDa protein produced either by the recombinant legiolysin-positive E. coli K12 clones or by L. pneumophila wild-type strains.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2958.1991.tb01886.x
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