Publication Date:
2007-08-11
Description:
Studies of the fat-derived hormone leptin have provided key insights into the molecular and neural components of feeding behavior and body weight regulation. An important challenge lies in understanding how the rewarding properties of food interact with, and can override, physiological satiety signals and promote overeating. We used functional magnetic resonance imaging to measure brain responses in two human patients with congenital leptin deficiency who were shown images of food before and after 7 days of leptin replacement therapy. Leptin was found to modulate neural activation in key striatal regions, suggesting that the hormone acts on neural circuits governing food intake to diminish the perception of food reward while enhancing the response to satiety signals generated during food consumption.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838941/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838941/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Farooqi, I Sadaf -- Bullmore, Edward -- Keogh, Julia -- Gillard, Jonathan -- O'Rahilly, Stephen -- Fletcher, Paul C -- 064351/Wellcome Trust/United Kingdom -- 068086/Wellcome Trust/United Kingdom -- G0001354/Medical Research Council/United Kingdom -- G9824984/Medical Research Council/United Kingdom -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2007 Sep 7;317(5843):1355. Epub 2007 Aug 9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University Department of Medicine and Department of Clinical Biochemistry, Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 2QQ, UK. isf20@cam.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17690262" target="_blank"〉PubMed〈/a〉
Keywords:
Adolescent
;
Adult
;
Brain Mapping
;
Corpus Striatum/drug effects/*physiology
;
Eating
;
Feeding Behavior/drug effects/*physiology
;
Female
;
Humans
;
Leptin/*deficiency/*physiology/therapeutic use
;
Magnetic Resonance Imaging
;
Male
;
Nucleus Accumbens/physiology
;
Satiation/physiology
;
Visual Perception/drug effects/physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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