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  • 1
    Publication Date: 2018-03-31
    Description: Author(s): R. K. Follett, J. G. Shaw, J. F. Myatt, J. P. Palastro, R. W. Short, and D. H. Froula Three-dimensional laser-plasma interaction simulations show that laser frequency detuning by an amount achievable with current laser technology can be used to suppress the two-plasmon decay (TPD) instability and the corresponding hot-electron generation. For the plasma conditions and laser configura... [Phys. Rev. Lett. 120, 135005] Published Fri Mar 30, 2018
    Keywords: Plasma and Beam Physics
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
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  • 2
    Publication Date: 2018-10-10
    Description: Author(s): R. K. Follett, J. G. Shaw, J. F. Myatt, V. N. Goncharov, D. H. Edgell, D. H. Froula, and J. P. Palastro Cross-beam energy transfer (CBET) is a laser-plasma instability that significantly impacts laser energy deposition in laser-driven inertial confinement fusion (ICF) experiments. Radiation-hydrodynamics simulations, which are used to design and tune ICF implosions, use ray-based CBET models, but exis... [Phys. Rev. E 98, 043202] Published Tue Oct 09, 2018
    Keywords: Plasma Physics
    Print ISSN: 1539-3755
    Electronic ISSN: 1550-2376
    Topics: Physics
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  • 3
    Publication Date: 2010-05-04
    Description: Bacteria coordinate expression of virulence determinants in response to localized microenvironments in their hosts. Here we show that Shigella flexneri, which causes dysentery, encounters varying oxygen concentrations in the gastrointestinal tract, which govern activity of its type three secretion system (T3SS). The T3SS is essential for cell invasion and virulence. In anaerobic environments (for example, the gastrointestinal tract lumen), Shigella is primed for invasion and expresses extended T3SS needles while reducing Ipa (invasion plasmid antigen) effector secretion. This is mediated by FNR (fumarate and nitrate reduction), a regulator of anaerobic metabolism that represses transcription of spa32 and spa33, virulence genes that regulate secretion through the T3SS. We demonstrate there is a zone of relative oxygenation adjacent to the gastrointestinal tract mucosa, caused by diffusion from the capillary network at the tips of villi. This would reverse the anaerobic block of Ipa secretion, allowing T3SS activation at its precise site of action, enhancing invasion and virulence.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750455/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750455/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marteyn, Benoit -- West, Nicholas P -- Browning, Douglas F -- Cole, Jeffery A -- Shaw, Jonathan G -- Palm, Fredrik -- Mounier, Joelle -- Prevost, Marie-Christine -- Sansonetti, Philippe -- Tang, Christoph M -- 084369/Wellcome Trust/United Kingdom -- Howard Hughes Medical Institute/ -- Medical Research Council/United Kingdom -- Wellcome Trust/United Kingdom -- England -- Nature. 2010 May 20;465(7296):355-8. doi: 10.1038/nature08970. Epub 2010 May 2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Molecular Microbiology and Infection, Department of Microbiology, Flowers Building, Imperial College London, London SW7 2AZ, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20436458" target="_blank"〉PubMed〈/a〉
    Keywords: Anaerobiosis/drug effects ; Animals ; Cells, Cultured ; Epithelial Cells/cytology/drug effects/metabolism/microbiology ; Fumarates/metabolism ; Gastrointestinal Tract/cytology/microbiology ; Gene Expression Regulation, Bacterial ; HeLa Cells ; Host-Pathogen Interactions/drug effects/*physiology ; Humans ; Mice ; Nitrates/metabolism ; Oxidation-Reduction ; Oxygen/analysis/*metabolism/pharmacology ; Rabbits ; Shigella flexneri/cytology/*metabolism/*pathogenicity ; Virulence/drug effects/genetics/physiology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 2018-06-19
    Description: Author(s): J. W. Bates, J. F. Myatt, J. G. Shaw, R. K. Follett, J. L. Weaver, R. H. Lehmberg, and S. P. Obenschain Cross-beam energy transfer (CBET) is a significant energy-loss mechanism in directly driven inertial-confinement-fusion (ICF) targets. One strategy for mitigating CBET is to increase the bandwidth of the laser light, thereby disrupting the resonant three-wave interactions that underlie this nonlinea... [Phys. Rev. E 97, 061202(R)] Published Mon Jun 18, 2018
    Keywords: Plasma Physics
    Print ISSN: 1539-3755
    Electronic ISSN: 1550-2376
    Topics: Physics
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  • 5
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 57 (1986), S. 1868-1871 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The NOVA laser has completed its first year of operation. During this period, emphasis has been placed on activation of the facility and of the numerous target and beam diagnostics. Two separate target chambers are in use. NOVA operation is separated into two broad functions: laser operations and experiments. The operations group provides the laser system control, operation, and data acquisition and the experiments group provides experiment definition, diagnostic instrumentation, and overall data processing. On the operations side, VAX 11/780 computers are used to set up diagnostic operating parameters and collect data recorded by the CAMAC and CCD modules. These data are delivered in files by electronic link to the Laser Experiments and Analysis Facility (LEAF) VAX 11/785 of the experiments group for processing. Film data are digitized at LEAF and the film data files are also processed on the LEAF VAX. The LEAF provides collection, processing, analysis, and archiving of the experimental data. The many applications software packages written for LEAF provide the experimental physicists and NOVA operations staff with programs and data bases for interpretation of experimental results. This software makes fundamental use of the ORACLE relational data base management system to both access the required data and archive the obtained results. Post-shot data processing produces sets of scalar values, x, y profiles and x, y, z contour data. The scalar data are stored in the ORACLE DB; the more extensive results are stored in binary files on disk. All data forms are accessed by a comprehensive software system, the electronic SHOTBOOK, developed around the ORACLE DBMS. This software also provides the means to archive relevant data about each experimental activity and allows the physicists to annotate displayed experimental results with technical comment.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Molecular microbiology 4 (1990), S. 0 
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Transposon mutagenesis was used to isolate insertion mutants of the photosynthetic bacterium Rhodobacter capsulatus which were unable to grow under aerobic conditions in the dark on malate, succinate or fumarate as sole carbon sources. Of five mutants isolated, all were deficient in C4-dicarboxylate transport. However, these mutants were still capable of photoheterotrophic growth, although at a slower rate than the wild type, on malate and succinate (but not fumarate). The mutated locus (designated dct) was complemented in trans using a cosmid gene bank. Subcloning and complementation analysis indicated that at least three closely linked genes essential for aerobic dicarboxylate transport were contained within an 8.3kb region of the Rhodobacter capsulatus chromosome.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Molecular microbiology 5 (1991), S. 0 
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: A periplasmic binding protein essential for high-affinity transport of the C4-dicarboxylates malate, succinate and fumarate across the cytoplasmic membrane of the purple photosynthetic bacterium Rhodobacter capsulatus has been purified to homogeneity and some of its ligand-binding properties characterized. The protein was not produced in a Tn5 insertion mutant unable to transport C4-dicarboxylates under aerobic conditions in the dark. Wild-type DNA corresponding to the location of the transposon insertion site was subcloned and a 1.5kb section sequenced. A complete open reading frame of 999bp was identified that encoded a 333-residue protein (DctP) with a molecular weight of 36 128 with a 26-residue amino-terminal signal peptide. The identity of this protein with the purified dicarboxylate-binding protein and the position of the predicted signal peptide cleavage site was confirmed by N-terminal sequencing. No significant homology with other proteins was detected in database searches. A GC-rich region of dyad symmetry was located 7bp downstream of the dctP translational stop codon. This structure may be of significance in regulating the relative abundance of DctP and other dct gene products which comprise the high-affinity dicarboxylate transport system in this bacterium.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Organometallic Chemistry 131 (1977), S. C33-C35 
    ISSN: 0022-328X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Scientometrics 12 (1987), S. 101-110 
    ISSN: 1588-2861
    Source: Springer Online Journal Archives 1860-2000
    Topics: Information Science and Librarianship , Nature of Science, Research, Systems of Higher Education, Museum Science
    Notes: Abstract An article by article analysis produced by ISI has been investigated to see whether this form of feedback might be useful to the editors. The data highlight the different roles of two medical journals, which are often regarded as similar. They also allow a parallel examination of the citation pattern of other items besides the standard scientific research articles.
    Type of Medium: Electronic Resource
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  • 10
    Publication Date: 1991-11-01
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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