Publication Date:
2013-04-20
Description:
Both bats and rats exhibit grid cells in medial entorhinal cortex that fire as they visit a regular array of spatial locations. In rats, grid-cell firing field properties correlate with theta-frequency rhythmicity of spiking and membrane-potential resonance; however, bat grid cells do not exhibit theta rhythmic spiking, generating controversy over the role of theta rhythm. To test whether this discrepancy reflects differences in rhythmicity at a cellular level, we performed whole-cell patch recordings from entorhinal neurons in both species to record theta-frequency resonance. Bat neurons showed no theta-frequency resonance, suggesting grid-cell coding via different mechanisms in bats and rats or lack of theta rhythmic contributions to grid-cell firing in either species.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Heys, James G -- MacLeod, Katrina M -- Moss, Cynthia F -- Hasselmo, Michael E -- New York, N.Y. -- Science. 2013 Apr 19;340(6130):363-7. doi: 10.1126/science.1233831.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Graduate Program for Neuroscience, Center for Memory and Brain, Boston University, 2 Cummington Street, Boston, MA 02215, USA. jimheys@bu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23599495" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
*Chiroptera
;
Entorhinal Cortex/cytology/*physiology
;
Female
;
Male
;
Membrane Potentials
;
Models, Neurological
;
Neurons/cytology/*physiology
;
Patch-Clamp Techniques
;
Rats
;
Rats, Long-Evans
;
*Theta Rhythm
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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