Publication Date:
1990-09-14
Description:
The application of isolated pancreatic islet transplantation for treatment of diabetes mellitus has been hampered by the vulnerability of islet allografts to immunologic rejection. Rat islet allografts that were transplanted into the thymus of recipients treated with a single injection of anti-lymphocyte serum survived indefinitely. A state of donor-specific unresponsiveness was achieved that permitted survival of a second donor strain islet allograft transplanted to an extrathymic site. Maturation of T cell precursors in a thymic microenvironment that is harboring foreign alloantigen may induce the selective unresponsiveness. This model provides an approach for pancreatic islet transplantation and a potential strategy for specific modification of the peripheral immune repertoire.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Posselt, A M -- Barker, C F -- Tomaszewski, J E -- Markmann, J F -- Choti, M A -- Naji, A -- DK26007/DK/NIDDK NIH HHS/ -- DK34878/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 1990 Sep 14;249(4974):1293-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia 19104.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2119056" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antilymphocyte Serum
;
Blood Glucose/metabolism
;
Diabetes Mellitus, Experimental/*surgery
;
Graft Enhancement, Immunologic
;
Immune Tolerance
;
*Islets of Langerhans Transplantation
;
Rats
;
Rats, Inbred Lew
;
Rats, Inbred WF
;
T-Lymphocytes/immunology
;
Thymus Gland/surgery
;
Transplantation, Heterotopic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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