Publication Date:
2000-07-21
Description:
The developmental mechanisms specifying digital identity have attracted 30 years of intense interest, but still remain poorly understood. Here, through experiments on chick foot development, we show digital identity is not a fixed property of digital primordia. Rather, digital identity is specified by the interdigital mesoderm, demonstrating a patterning function for this tissue before its regression. More posterior interdigits specify more posterior digital identities, and each primordium will develop in accordance with the most posterior cues received. Furthermore, inhibition of interdigital bone morphogenetic protein (BMP) signaling can transform digit identity, suggesting a role for BMPs in this process.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dahn, R D -- Fallon, J F -- HD32551/HD/NICHD NIH HHS/ -- T32HD07477/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 2000 Jul 21;289(5478):438-41.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anatomy, University of Wisconsin, 1300 University Avenue, Madison, WI 53706, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10903202" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
*Body Patterning
;
Bone Morphogenetic Proteins/*physiology
;
Chick Embryo
;
Foot/*embryology
;
Hedgehog Proteins
;
Hindlimb/embryology
;
Limb Buds/anatomy & histology/embryology
;
Mesoderm/*physiology
;
Models, Biological
;
Proteins/pharmacology/physiology
;
Signal Transduction
;
*Trans-Activators
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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