Publication Date:
2006-12-02
Description:
Signaling by cell surface receptors and heterotrimeric guanine nucleotide-binding proteins (G proteins) is one of the most exhaustively studied processes in the cell but remains a major focus of molecular pharmacology research. The pheromone-response system in yeast (see the Connections Map at Science's Signal Transduction Knowledge Environment) has provided numerous major advances in our understanding of G protein signaling and regulation. However, the basic features of this prototypical pathway have remained largely unchanged since the mid-1990s. New tools available in yeast are beginning to uncover new pathway components and interactions and have revealed signaling in unexpected locations within the cell.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Slessareva, Janna E -- Dohlman, Henrik G -- P01-GM065533/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2006 Dec 1;314(5804):1412-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599-7260, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17138892" target="_blank"〉PubMed〈/a〉
Keywords:
Cell Membrane/*metabolism
;
Endosomal Sorting Complexes Required for Transport
;
Endosomes/*metabolism
;
GTP-Binding Protein alpha Subunits/metabolism
;
GTP-Binding Protein alpha Subunits, Gq-G11
;
GTP-Binding Protein beta Subunits/metabolism
;
GTP-Binding Protein gamma Subunits/metabolism
;
GTPase-Activating Proteins
;
Heterotrimeric GTP-Binding Proteins/*metabolism
;
Intracellular Membranes/metabolism
;
Models, Biological
;
Phosphatidylinositol 3-Kinases/metabolism
;
Protein-Serine-Threonine Kinases/metabolism
;
RGS Proteins/metabolism
;
Receptors, Mating Factor/metabolism
;
Saccharomyces cerevisiae/genetics/*metabolism
;
Saccharomyces cerevisiae Proteins/metabolism
;
*Signal Transduction
;
Vacuolar Sorting Protein VPS15
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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