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  • 1
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    Heavy Rydberg behaviour in high vibrational levels of some ion-pair states of the halogens and inter-halogens (2015)
    American Institute of Physics (AIP)
    Details
    Publication Date: 2015-05-29
    Description: We report the identification of heavy Rydberg resonances in the ion-pair spectra of I 2 , Cl 2 , ICl, and IBr. Extensive vibrational progressions are analysed in terms of the energy dependence of the quantum defect δ( E b ) rather than as Dunham expansions. This is shown to define the heavy Rydberg region, providing a more revealing fit to the data with fewer coefficients and leads just as easily to numbering data sets separated by gaps in the observed vibrational progressions. Interaction of heavy Rydberg states with electronic Rydberg states at avoided crossings on the inner wall of the ion-pair potential is shown to produce distinctive changes in the energy dependence of δ( E b ), with weak and strong interactions readily distinguished. Heavy Rydberg behaviour is found to extend well below near-dissociation states, down to vibrational levels ∼18 000-20 000 cm −1 below dissociation. The rapid semi-classical calculation of δ( E b ) for heavy Rydberg states is emphasised and shows their absolute magnitude to be essentially the volume of phase space excluded from the vibrational motion by avoiding core-core penetration of the ions.
    Print ISSN: 0021-9606
    Electronic ISSN: 1089-7690
    Topics: Chemistry and Pharmacology , Physics
    Published by American Institute of Physics (AIP)
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  • 2
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    Atomic Resolution Structure of Monomorphic Aβ42 Amyloid Fibrils (2016)
    American Chemical Society (ACS)
    Details
    Publication Date: 2016-07-16
    Description: Journal of the American Chemical Society DOI: 10.1021/jacs.6b05129
    Print ISSN: 0002-7863
    Electronic ISSN: 1520-5126
    Topics: Chemistry and Pharmacology
    Published by American Chemical Society (ACS)
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  • 3
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    SURVIVING METAMORPHISM: TAPHONOMY OF FOSSIL ASSEMBLAGES IN MARBLE AND CALC-SILICATE SCHIST (2015)
    Society for Sedimentary Geology (SEPM)
    In: PALAIOS
    Details
    Publication Date: 2015-09-30
    Description: Devonian massive graphitic marble and calc-silicate schist, belonging to the Lower Formation of the Nevado-Filábride Complex of the Internal Zones of the Betic Cordillera, crop out extensively near Águilas (Murcia, SE Spain). These rocks contain a rich fossil record even though they have undergone Alpine metamorphism and deformation (350–480°C; 2 Kb). In this paper, we focus on the taphonomic characteristics of the fossil assemblages to infer the depositional processes that can be reconstructed even after metamorphism. The most abundant fossils are crinoids, followed by phacelloid colonial rugose corals, brachiopods, cephalopods (ammonoids and orthoceratids), and possible gastropods and benthic foraminifers. Crinoids occur as isolated columnal ossicles, as well as articulated portions of columns (pluricolumnals). One complete calyx was also found. Taphonomically delicate crinoids are preserved in the calc-silicate schist beds. In the massive marble beds, crinoids occur mostly as disarticulated ossicles, but they still bear delicate ornamental features. Some corals preserve external walls. The low degree of abrasion indicates disarticulation of the crinoids due to exposure in the taphonomic active zone (TAZ), but under low-energy conditions. Articulated crinoids are preserved due to catastrophic burial events. The preservation of the fauna allows the differentiation of background versus event biostratinomic processes even after being highly altered by metamorphism.
    Print ISSN: 0883-1351
    Electronic ISSN: 0883-1351
    Topics: Geosciences
    Published by Society for Sedimentary Geology (SEPM)
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  • 4
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    Trace analysis in EPMA (2012)
    Institute of Physics (IOP)
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    Publication Date: 2012-03-09
    Description: Trace element micro-analysis has evolved steadily since the early days of EPMA, yet remains an extraordinarily challenging subject. The enhanced capabilities of modern instrumentation, including the use of spectrometers with high X-ray collection efficiencies, high brightness electron sources, and improved stability all contribute to our ability to improve detection limits and analytical spatial resolution. Along with much improved software for data acquisition and analysis, recent progress in EPMA has made the trace realm more accessible than ever. High count precision can be obtained in order to easily bring analytical sensitivity into the single ppm range, but accuracy remains the greatest struggle. With the exception of the calibration, all sources of error encountered in major element analysis are magnified in trace analysis, and other sources become apparent where high spatial resolution is needed. Beam damage and charge effects are difficult problems in high sensitivity, ...
    Print ISSN: 1757-8981
    Electronic ISSN: 1757-899X
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by Institute of Physics (IOP)
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  • 5
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    Induced electro-optic effects in single-walled carbon nanotubes. II. Hydrodynamics of nanotubes in viscous media (2011)
    American Physical Society (APS)
    Details
    Publication Date: 2011-04-08
    Description: Author(s): T. J. Robb-Smith, K. J. Donovan, K. Scott, and M. Somerton Single-walled carbon nanotubes (SWNTs), when suspended in viscous media in an applied electric field, are caused to align through an induced dipole moment. The consequent introduction of anisotropy into what was a previously isotropic suspension of SWNTs gives rise to induced optical effects such as... [Phys. Rev. B 83, 155415] Published Thu Apr 07, 2011
    Keywords: Surface physics, nanoscale physics, low-dimensional systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 6
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    Induced electro-optic effects in single-walled carbon nanotubes. I. Polarizability of metallic nanotubes (2011)
    American Physical Society (APS)
    Details
    Publication Date: 2011-04-08
    Description: Author(s): T. J. Robb-Smith, K. J. Donovan, K. Scott, and M. Somerton The polarizability of single-walled carbon nanotubes (SWNTs) results in an induced dipole moment which in turn allows their alignment, when in suspension, in an applied electric field. The consequent introduction of anisotropy into what was a previously isotropic suspension of SWNTs gives rise to in... [Phys. Rev. B 83, 155414] Published Thu Apr 07, 2011
    Keywords: Surface physics, nanoscale physics, low-dimensional systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 7
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    Programmable and Multiparameter DNA-Based Logic Platform For Cancer Recognition and Targeted Therapy (2014)
    American Chemical Society (ACS)
    Details
    Publication Date: 2014-11-26
    Description: Journal of the American Chemical Society DOI: 10.1021/ja509263k
    Print ISSN: 0002-7863
    Electronic ISSN: 1520-5126
    Topics: Chemistry and Pharmacology
    Published by American Chemical Society (ACS)
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  • 8
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    Fast Bayesian inference for exoplanet discovery in radial velocity data (2015)
    Oxford University Press
    Details
    Publication Date: 2015-03-12
    Description: Inferring the number of planets N in an exoplanetary system from radial velocity (RV) data is a challenging task. Recently, it has become clear that RV data can contain periodic signals due to stellar activity, which can be difficult to distinguish from planetary signals. However, even doing the inference under a given set of simplifying assumptions (e.g. no stellar activity) can be difficult. It is common for the posterior distribution for the planet parameters, such as orbital periods, to be multimodal and to have other awkward features. In addition, when N is unknown, the marginal likelihood (or evidence) as a function of N is required. Rather than doing separate runs with different trial values of N , we propose an alternative approach using a transdimensional Markov Chain Monte Carlo method within nested sampling. The posterior distribution for N can be obtained with a single run. We apply the method to Oph and Gliese 581, finding moderate evidence for additional signals in Oph with periods of 36.11 ± 0.034, 75.58 ± 0.80, and 1709 ± 183 d; the posterior probability that at least one of these exists is 85 per cent. The results also suggest Gliese 581 hosts many (7–15) ‘planets’ (or other causes of other periodic signals), but only 4–6 have well determined periods. The analysis of both of these data sets shows phase transitions exist which are difficult to negotiate without nested sampling.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
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  • 9
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    The landscape of somatic copy-number alteration across human cancers (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-02-19
    Description: A powerful way to discover key genes with causal roles in oncogenesis is to identify genomic regions that undergo frequent alteration in human cancers. Here we present high-resolution analyses of somatic copy-number alterations (SCNAs) from 3,131 cancer specimens, belonging largely to 26 histological types. We identify 158 regions of focal SCNA that are altered at significant frequency across several cancer types, of which 122 cannot be explained by the presence of a known cancer target gene located within these regions. Several gene families are enriched among these regions of focal SCNA, including the BCL2 family of apoptosis regulators and the NF-kappaBeta pathway. We show that cancer cells containing amplifications surrounding the MCL1 and BCL2L1 anti-apoptotic genes depend on the expression of these genes for survival. Finally, we demonstrate that a large majority of SCNAs identified in individual cancer types are present in several cancer types.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826709/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826709/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beroukhim, Rameen -- Mermel, Craig H -- Porter, Dale -- Wei, Guo -- Raychaudhuri, Soumya -- Donovan, Jerry -- Barretina, Jordi -- Boehm, Jesse S -- Dobson, Jennifer -- Urashima, Mitsuyoshi -- Mc Henry, Kevin T -- Pinchback, Reid M -- Ligon, Azra H -- Cho, Yoon-Jae -- Haery, Leila -- Greulich, Heidi -- Reich, Michael -- Winckler, Wendy -- Lawrence, Michael S -- Weir, Barbara A -- Tanaka, Kumiko E -- Chiang, Derek Y -- Bass, Adam J -- Loo, Alice -- Hoffman, Carter -- Prensner, John -- Liefeld, Ted -- Gao, Qing -- Yecies, Derek -- Signoretti, Sabina -- Maher, Elizabeth -- Kaye, Frederic J -- Sasaki, Hidefumi -- Tepper, Joel E -- Fletcher, Jonathan A -- Tabernero, Josep -- Baselga, Jose -- Tsao, Ming-Sound -- Demichelis, Francesca -- Rubin, Mark A -- Janne, Pasi A -- Daly, Mark J -- Nucera, Carmelo -- Levine, Ross L -- Ebert, Benjamin L -- Gabriel, Stacey -- Rustgi, Anil K -- Antonescu, Cristina R -- Ladanyi, Marc -- Letai, Anthony -- Garraway, Levi A -- Loda, Massimo -- Beer, David G -- True, Lawrence D -- Okamoto, Aikou -- Pomeroy, Scott L -- Singer, Samuel -- Golub, Todd R -- Lander, Eric S -- Getz, Gad -- Sellers, William R -- Meyerson, Matthew -- K08 AR055688/AR/NIAMS NIH HHS/ -- K08 AR055688-03/AR/NIAMS NIH HHS/ -- K08 AR055688-04/AR/NIAMS NIH HHS/ -- K08 CA122833/CA/NCI NIH HHS/ -- K08 CA122833-01A1/CA/NCI NIH HHS/ -- K08 CA122833-02/CA/NCI NIH HHS/ -- K08 CA122833-03/CA/NCI NIH HHS/ -- K08 CA134931/CA/NCI NIH HHS/ -- K08CA122833/CA/NCI NIH HHS/ -- P01CA 098101/CA/NCI NIH HHS/ -- P01CA085859/CA/NCI NIH HHS/ -- P50CA90578/CA/NCI NIH HHS/ -- R01 CA109038/CA/NCI NIH HHS/ -- R01 GM074024/GM/NIGMS NIH HHS/ -- R01CA109038/CA/NCI NIH HHS/ -- R01CA109467/CA/NCI NIH HHS/ -- T32 GM007753/GM/NIGMS NIH HHS/ -- U24 CA126546/CA/NCI NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2010 Feb 18;463(7283):899-905. doi: 10.1038/nature08822.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cancer Program and Medical and Population Genetics Group, The Broad Institute of M.I.T. and Harvard, 7 Cambridge Center.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20164920" target="_blank"〉PubMed〈/a〉
    Keywords: Apoptosis/genetics ; Cell Line, Tumor ; Cell Survival/genetics ; DNA Copy Number Variations/*genetics ; Gene Amplification/genetics ; Gene Dosage/*genetics ; Genomics ; Humans ; Multigene Family/genetics ; Myeloid Cell Leukemia Sequence 1 Protein ; Neoplasms/classification/*genetics/pathology ; Proto-Oncogene Proteins c-bcl-2/genetics ; Signal Transduction ; bcl-X Protein/genetics
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 10
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    Massive star formation within the Leo 'primordial' ring (2009)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2009-02-20
    Description: Few intergalactic, plausibly primordial clouds of neutral atomic hydrogen (H(i)) have been found in the local Universe, suggesting that such structures have either dispersed, become ionized or produced a stellar population on gigayear timescales. The Leo ring, a massive (M(H(i)) approximately 1.8 x 10(9)M[symbol: see text], M[symbol: see text] denoting the solar mass), 200-kpc-wide structure orbiting the galaxies M105 and NGC 3384 with a 4-Gyr period, is a candidate primordial cloud. Despite repeated atttempts, it has previously been seen only from H i emission, suggesting the absence of a stellar population. Here we report the detection of ultraviolet light from gaseous substructures of the Leo ring, which we attribute to recent massive star formation. The ultraviolet colour of the detected complexes is blue, implying the onset of a burst of star formation or continuous star formation of moderate (approximately 10(8)-yr) duration. Measured ultraviolet-visible photometry favours models with low metallicity (Z approximately Z[symbol: see text]/50-Z[symbol: see text]/5, Z[symbol: see text] denoting the solar metallicity), that is, a low proportion of elements heavier than helium, although spectroscopic confirmation is needed. We speculate that the complexes are dwarf galaxies observed during their formation, but distinguished by their lack of a dark matter component. In this regard, they resemble tidal dwarf galaxies, although without the enrichment preceding tidal stripping. If structures like the Leo ring were common in the early Universe, they may have produced a large, yet undetected, population of faint, metal-poor, halo-lacking dwarf galaxies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thilker, David A -- Donovan, Jennifer -- Schiminovich, David -- Bianchi, Luciana -- Boissier, Samuel -- de Paz, Armando Gil -- Madore, Barry F -- Martin, D Christopher -- Seibert, Mark -- England -- Nature. 2009 Feb 19;457(7232):990-3. doi: 10.1038/nature07780.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Astrophysical Sciences, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA. dthilker@pha.jhu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19225520" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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