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  • 1
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    Ultrasensitivity from opposing phosphorylations [Systems Biology] (2014)
    National Academy of Sciences
    Details
    Publication Date: 2014-09-17
    Description: Circadian oscillations are generated by the purified cyanobacterial clock proteins, KaiA, KaiB, and KaiC, through rhythmic interactions that depend on multisite phosphorylation of KaiC. However, the mechanisms that allow these phosphorylation reactions to robustly control the timing of oscillations over a range of protein stoichiometries are not clear. We show...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 2
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    On the track of a Scottish impact structure: a detrital zircon and apatite provenance study of the Stac Fada Member and wider Stoer Group, NW Scotland (2019)
    Cambridge University Press
    Details
    Publication Date: 2019
    Description: 〈div data-abstract-type="normal"〉〈p〉The Stac Fada Member of the Stoer Group, within the Torridonian succession of NW Scotland, is a melt-rich, impact-related deposit that has not been conclusively correlated with any known impact structure. However, a gravity low approximately 50 km east of the preserved Stac Fada Member outcrops has recently been proposed as the associated impact site. We investigate the location of the impact structure through a provenance study of detrital zircon and apatite in five samples from the Stoer Group. Our zircon U–Pb data are dominated by Archaean grains (〉 2.5 Ga), consistent with earlier interpretations that the detritus was largely derived from local Lewisian Gneiss Complex, whereas the apatite data (the first for the Stoer Group) display a single major peak at 〈span〉c.〈/span〉 1.7 Ga, consistent with regional Laxfordian metamorphism. The almost complete absence of Archaean-aged apatite is best explained by later heating of the 〉 2.5 Ga Lewisian basement (the likely source region) above the closure temperature of the apatite U–Pb system (〈span〉c.〈/span〉 375–450°C). The U–Pb age distributions for zircon and apatite show no significant variation with stratigraphic height. This may be interpreted as evidence that there was no major change in provenance during the course of deposition of the Stoer Group or, if there was any significant change, the different source regions were characterized by similar apatite and zircon U–Pb age populations. Consequently, the new data do not provide independent constraints on the location of the structure associated with the Stac Fada Member impact event.〈/p〉〈/div〉
    Print ISSN: 0016-7568
    Electronic ISSN: 1469-5081
    Topics: Geosciences
    Published by Cambridge University Press
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  • 3
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    Quantal duration of auditory memories (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-12-13
    Description: Neuronal responses in the caudomedial neostriatum (NCM) of adult zebra finches (Taeniopygia guttata) decreased upon repeated, unreinforced presentations of conspecific song, calls, or other complex sounds. This "stimulus-specific habituation" is a form of learning, and its spontaneous loss, a form of "forgetting." Spontaneous forgetting occurred only at narrowly defined times (2 to 3, 6 to 7, 14 to 15, 17 to 18.5, 46 to 48, or 85 to 89 hours after first exposure to a stimulus), determined by stimulus class, number of presentations, and interval between presentations. The first five forgetting times coincided with periods when gene expression and protein synthesis in NCM were required for maintenance of the longer lasting (85 to 89 hours) habituation. The number of successive episodes of gene expression induced by a stimulus, but occurring long after stimulus presentation, appears to determine the quantal duration of auditory memories.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chew, S J -- Vicario, D S -- Nottebohm, F -- MH18343/MH/NIMH NIH HHS/ -- MH40900/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1996 Dec 13;274(5294):1909-14.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Animal Behavior, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8943204" target="_blank"〉PubMed〈/a〉
    Keywords: Acoustic Stimulation ; Animals ; Birds/*physiology ; Cycloheximide/pharmacology ; Dactinomycin/pharmacology ; Female ; Gene Expression ; *Habituation, Psychophysiologic ; Male ; *Memory ; Neostriatum/*physiology ; *Neuronal Plasticity ; Neurons/*physiology ; Protein Biosynthesis ; RNA/biosynthesis ; Time Factors ; Vocalization, Animal
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Neurodegeneration. C9ORF72 repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficits (2015)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2015-05-16
    Description: The major genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis is a G4C2 repeat expansion in C9ORF72. Efforts to combat neurodegeneration associated with "c9FTD/ALS" are hindered by a lack of animal models recapitulating disease features. We developed a mouse model to mimic both neuropathological and clinical c9FTD/ALS phenotypes. We expressed (G4C2)66 throughout the murine central nervous system by means of somatic brain transgenesis mediated by adeno-associated virus. Brains of 6-month-old mice contained nuclear RNA foci, inclusions of poly(Gly-Pro), poly(Gly-Ala), and poly(Gly-Arg) dipeptide repeat proteins, as well as TDP-43 pathology. These mouse brains also exhibited cortical neuron and cerebellar Purkinje cell loss, astrogliosis, and decreased weight. (G4C2)66 mice also developed behavioral abnormalities similar to clinical symptoms of c9FTD/ALS patients, including hyperactivity, anxiety, antisocial behavior, and motor deficits.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692360/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692360/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chew, Jeannie -- Gendron, Tania F -- Prudencio, Mercedes -- Sasaguri, Hiroki -- Zhang, Yong-Jie -- Castanedes-Casey, Monica -- Lee, Chris W -- Jansen-West, Karen -- Kurti, Aishe -- Murray, Melissa E -- Bieniek, Kevin F -- Bauer, Peter O -- Whitelaw, Ena C -- Rousseau, Linda -- Stankowski, Jeannette N -- Stetler, Caroline -- Daughrity, Lillian M -- Perkerson, Emilie A -- Desaro, Pamela -- Johnston, Amelia -- Overstreet, Karen -- Edbauer, Dieter -- Rademakers, Rosa -- Boylan, Kevin B -- Dickson, Dennis W -- Fryer, John D -- Petrucelli, Leonard -- P01 NS084974/NS/NINDS NIH HHS/ -- P01NS084974/NS/NINDS NIH HHS/ -- P50 AG016574/AG/NIA NIH HHS/ -- P50AG016574/AG/NIA NIH HHS/ -- R01 NS077402/NS/NINDS NIH HHS/ -- R01ES20395/ES/NIEHS NIH HHS/ -- R01NS063964/NS/NINDS NIH HHS/ -- R01NS077402/NS/NINDS NIH HHS/ -- R01NS088689/NS/NINDS NIH HHS/ -- R21 NS084528/NS/NINDS NIH HHS/ -- R21NS079807/NS/NINDS NIH HHS/ -- R21NS084528/NS/NINDS NIH HHS/ -- R21NS089979/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2015 Jun 5;348(6239):1151-4. doi: 10.1126/science.aaa9344. Epub 2015 May 14.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA. Neurobiology of Disease Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. ; Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA. ; Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA. ; German Center for Neurodegenerative Diseases (DZNE) Munich, Feodor-Lynen-Strasse 17, 81337 Munich, Germany. Institute for Metabolic Biochemistry, Ludwig-Maximilians University Munich, Feodor-Lynen-Strasse 17, 81337 Munich, Germany. Munich Cluster of Systems Neurology (SyNergy), Munich, Germany. ; Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA. Neurobiology of Disease Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. petrucelli.leonard@mayo.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25977373" target="_blank"〉PubMed〈/a〉
    Keywords: Amyotrophic Lateral Sclerosis/*genetics/pathology ; Animals ; Antisocial Personality Disorder/genetics/pathology ; Cerebral Cortex/metabolism/pathology ; DNA-Binding Proteins/*genetics ; Dependovirus ; Dipeptides/metabolism ; *Disease Models, Animal ; Frontotemporal Dementia/*genetics/pathology ; Gene Transfer Techniques ; HEK293 Cells ; Humans ; *Mice ; Proteins/*genetics ; Purkinje Cells/metabolism/pathology ; RNA, Nuclear/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Detecting magma-poor orogens in the detrital record (2016)
    Geological Society of America (GSA)
    In: Geology
    Details
    Publication Date: 2016-10-08
    Description: The clastic record is commonly interrogated by analysis of detrital heavy mineral assemblages, with the bulk of modern detrital geochronological studies employing U-Pb dating of detrital zircon. However, the bias of zircon toward felsic igneous sources, and the limited ability of the U-Pb system in zircon to record low- to medium-grade metamorphic events, means that the U-Pb detrital zircon record is largely insensitive to magma-poor orogens. In this study, U-Pb ages were obtained by laser ablation–inductively coupled plasma–mass spectrometry for apatite and rutile extracted from alluvium of the French Broad River (FBR) in the southern Appalachians (southeastern United States). In contrast to previously published FBR U-Pb zircon data sets, which yield essentially no record of the most recent Appalachian metamorphic events (ca. 320 Ma) associated with assembly of Pangea, the U-Pb detrital rutile and especially the U-Pb apatite systems together provide a complete record of complex polyphase Appalachian orogenesis. It is unexpected that the apatite and rutile U-Pb Appalachian age populations differ significantly, with probable low-temperature breakdown of rutile biasing the rutile data set toward the most recent (Alleghanian) metamorphic event. These data make the FBR one of the most intensely studied river systems globally for multiproxy single-grain U-Pb analysis, clearly demonstrate dependence of provenance information on mineral proxy choice, and emphasize the resolving power of multiproxy provenance studies.
    Print ISSN: 0091-7613
    Electronic ISSN: 1943-2682
    Topics: Geosciences
    Published by Geological Society of America (GSA)
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  • 6
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    Detecting magma-poor orogens in the detrital record (2016)
    Geological Society of America (GSA)
    In: Geology
    Details
    Publication Date: 2016-10-14
    Description: The clastic record is commonly interrogated by analysis of detrital heavy mineral assemblages, with the bulk of modern detrital geochronological studies employing U-Pb dating of detrital zircon. However, the bias of zircon toward felsic igneous sources, and the limited ability of the U-Pb system in zircon to record low- to medium-grade metamorphic events, means that the U-Pb detrital zircon record is largely insensitive to magma-poor orogens. In this study, U-Pb ages were obtained by laser ablation–inductively coupled plasma–mass spectrometry for apatite and rutile extracted from alluvium of the French Broad River (FBR) in the southern Appalachians (southeastern United States). In contrast to previously published FBR U-Pb zircon data sets, which yield essentially no record of the most recent Appalachian metamorphic events (ca. 320 Ma) associated with assembly of Pangea, the U-Pb detrital rutile and especially the U-Pb apatite systems together provide a complete record of complex polyphase Appalachian orogenesis. It is unexpected that the apatite and rutile U-Pb Appalachian age populations differ significantly, with probable low-temperature breakdown of rutile biasing the rutile data set toward the most recent (Alleghanian) metamorphic event. These data make the FBR one of the most intensely studied river systems globally for multiproxy single-grain U-Pb analysis, clearly demonstrate dependence of provenance information on mineral proxy choice, and emphasize the resolving power of multiproxy provenance studies.
    Print ISSN: 0091-7613
    Electronic ISSN: 1943-2682
    Topics: Geosciences
    Published by Geological Society of America (GSA)
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  • 7
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    Oil and Gas Developments in Europe in 1989 (1990)
    American Association of Petroleum Geologists
    Details
    Publication Date: 1990-01-01
    Print ISSN: 0149-1423
    Electronic ISSN: 1943-2674
    Topics: Geosciences
    Published by American Association of Petroleum Geologists
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  • 8
    Electronic Resource
    Electronic Resource
    On the potency of spaces with generalized dispersion points under maps and functions (1977)
    Springer
    Acta mathematica hungarica 29 (1977), S. 51-53 
    Details
    ISSN: 1588-2632
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01896466
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    A COMPARISON OF COUPLED AND SEGREGATED ITERATIVE SOLUTION TECHNIQUE FOR INCOMPRESSIBLE SWIRLING FLOW (1996)
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 22 (1996), S. 353-373 
    Details
    ISSN: 0271-2091
    Keywords: Navier-Stokes equations ; finite differences ; unsymmetric linear systems ; Krylov subspace methods ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: In many popular solution algorithms for the incompressible Navier-Stoke equations the coupling between the momentum equations is neglected when the linearized momentum equations are solved to update the velocities. This is known to lead to poor convergence in highly swirling flows where coupling between the radial and tangential momentum equations is strong. Here we propose a coupled solution algorithm in which the linearized momentum and continuity equations are solved simultaneously. Comparisons between the new method and the well-known SIMPLEC method are presented.
    Additional Material: 23 Ill.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Development of a computer program for the prediction of flow in a rotating cavity (1984)
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 4 (1984), S. 667-683 
    Details
    ISSN: 0271-2091
    Keywords: Rotating Flow ; Finite Differences ; Numerical Stability ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A computer program has been developed to predict laminar source-sink flow in a rotating cylindrical cavity. Although the program is based on a standard finite difference technique for recirculating flow, it incorporates two novel features. Step changes in grid size are employed to obtain sufficient resolution in the boundary layers and special treatment is given to the solution of the pressure correction equations, in the ‘SIMPLE’ algorithm, in order to improve the convergence properties of the method. Results are presented both for the flow in an infinite rotating cylindrical annulus and a finite rotating cylindrical cavity, with the inner cylindrical surface acting as a uniform source and the outer cylinder as a sink. These show good agreement with existing analytical solutions and illustrate some of the problems associated with the computation of rapidly rotating flows.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/fld.1650040706
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