Publication Date:
2013-12-07
Description:
Dyslexia is a severe and persistent reading and spelling disorder caused by impairment in the ability to manipulate speech sounds. We combined functional magnetic resonance brain imaging with multivoxel pattern analysis and functional and structural connectivity analysis in an effort to disentangle whether dyslexics' phonological deficits are caused by poor quality of the phonetic representations or by difficulties in accessing intact phonetic representations. We found that phonetic representations are hosted bilaterally in primary and secondary auditory cortices and that their neural quality (in terms of robustness and distinctness) is intact in adults with dyslexia. However, the functional and structural connectivity between the bilateral auditory cortices and the left inferior frontal gyrus (a region involved in higher-level phonological processing) is significantly hampered in dyslexics, suggesting deficient access to otherwise intact phonetic representations.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932003/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932003/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boets, Bart -- Op de Beeck, Hans P -- Vandermosten, Maaike -- Scott, Sophie K -- Gillebert, Celine R -- Mantini, Dante -- Bulthe, Jessica -- Sunaert, Stefan -- Wouters, Jan -- Ghesquiere, Pol -- 090961/Wellcome Trust/United Kingdom -- 098771/Wellcome Trust/United Kingdom -- 098771/Z/12/Z/Wellcome Trust/United Kingdom -- 101253/Wellcome Trust/United Kingdom -- 101253/Z/13/Z/Wellcome Trust/United Kingdom -- 284101/European Research Council/International -- WT090961MA/Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2013 Dec 6;342(6163):1251-4. doi: 10.1126/science.1244333.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Child and Adolescent Psychiatry, KU Leuven, 3000 Leuven, Belgium.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24311693" target="_blank"〉PubMed〈/a〉
Keywords:
Adult
;
Auditory Cortex/*physiopathology
;
Brain/*physiopathology
;
Brain Mapping
;
Dyslexia/*physiopathology
;
Female
;
Frontal Lobe/*physiopathology
;
Humans
;
Linguistics
;
Magnetic Resonance Imaging
;
Male
;
Neural Pathways
;
Parietal Lobe/physiopathology
;
*Phonetics
;
Reading
;
*Speech Perception
;
Temporal Lobe/physiopathology
;
Young Adult
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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