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  • 1
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    Female x male interactions in Drosophila sperm competition (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-01-08
    Description: In several organisms, the success of a male's sperm in multiply inseminated females depends on the male's genotype. In Drosophila, the female also plays a role in determining which sperm are successful. Pairwise tests among six isogenic lines of Drosophila melanogaster were performed to determine whether there is a genotype-specific interaction in the success of sperm. The success of a particular male's sperm was found to depend on the genotype of the female with which he mates, providing evidence for an interaction with profound evolutionary consequences.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Clark, A G -- Begun, D J -- Prout, T -- New York, N.Y. -- Science. 1999 Jan 8;283(5399):217-20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Pennsylvania State University, University Park, PA 16802, USA. c92@psu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9880253" target="_blank"〉PubMed〈/a〉
    Keywords: Analysis of Variance ; Animals ; *Biological Evolution ; Computer Simulation ; Drosophila melanogaster/genetics/*physiology ; Female ; Genetic Variation ; Genotype ; Male ; Models, Biological ; Sex Characteristics ; *Sexual Behavior, Animal ; Spermatozoa/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Origin and spread of de novo genes in Drosophila melanogaster populations (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-01-25
    Description: Comparative genomic analyses have revealed that genes may arise from ancestrally nongenic sequence. However, the origin and spread of these de novo genes within populations remain obscure. We identified 142 segregating and 106 fixed testis-expressed de novo genes in a population sample of Drosophila melanogaster. These genes appear to derive primarily from ancestral intergenic, unexpressed open reading frames, with natural selection playing a significant role in their spread. These results reveal a heretofore unappreciated dynamism of gene content.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391638/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391638/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhao, Li -- Saelao, Perot -- Jones, Corbin D -- Begun, David J -- GM084056/GM/NIGMS NIH HHS/ -- R01 GM084056/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2014 Feb 14;343(6172):769-72. doi: 10.1126/science.1248286. Epub 2014 Jan 23.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Evolution and Ecology, University of California, Davis, CA 95616, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24457212" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Drosophila melanogaster/*genetics ; *Evolution, Molecular ; Female ; Gene Expression ; Gene Expression Regulation ; *Genes, Insect ; Genetic Association Studies ; Male ; Open Reading Frames ; Selection, Genetic ; Testis/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-06-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Garsin, Danielle A -- Villanueva, Jacinto M -- Begun, Jakob -- Kim, Dennis H -- Sifri, Costi D -- Calderwood, Stephen B -- Ruvkun, Gary -- Ausubel, Frederick M -- GM48707/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2003 Jun 20;300(5627):1921.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics, Massachusetts General Hospital, Boston, MA 02114, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12817143" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Animals ; Caenorhabditis elegans/genetics/immunology/*microbiology/*physiology ; Caenorhabditis elegans Proteins/genetics/physiology ; Enterococcus faecalis/*pathogenicity/physiology ; Escherichia coli/*pathogenicity/physiology ; Forkhead Transcription Factors ; Longevity ; Mutation ; Phenotype ; Phosphatidylinositol 3-Kinases/genetics/physiology ; Receptor, Insulin/genetics/*physiology ; Staphylococcus aureus/*pathogenicity/physiology ; Transcription Factors/genetics/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    CGD and anakinra [Medical Sciences] (2014)
    National Academy of Sciences
    Details
    Publication Date: 2014-03-05
    Description: Patients with chronic granulomatous disease (CGD) have a mutated NADPH complex resulting in defective production of reactive oxygen species; these patients can develop severe colitis and are highly susceptible to invasive fungal infection. In NADPH oxidase-deficient mice, autophagy is defective but inflammasome activation is present despite lack of reactive oxygen...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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