Publication Date:
2010-02-12
Description:
Delta-like 4 (DLL4)-mediated Notch signalling has emerged as an attractive target for cancer therapy. However, the potential side effects of blocking this pathway remain uncertain. Here we show that chronic DLL4 blockade causes pathological activation of endothelial cells, disrupts normal organ homeostasis and induces vascular tumours, raising important safety concerns.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yan, Minhong -- Callahan, Christopher A -- Beyer, Joseph C -- Allamneni, Krishna P -- Zhang, Gu -- Ridgway, John Brady -- Niessen, Kyle -- Plowman, Greg D -- England -- Nature. 2010 Feb 11;463(7282):E6-7. doi: 10.1038/nature08751.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Tumor Biology and Angiogenesis, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA. minhong@gene.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20147986" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antineoplastic Agents/*adverse effects/pharmacology
;
Drug-Induced Liver Injury/pathology/physiopathology
;
Endothelial Cells/drug effects/pathology
;
Humans
;
Intracellular Signaling Peptides and Proteins/*antagonists &
;
inhibitors/metabolism
;
Macaca fascicularis
;
Membrane Proteins/*antagonists & inhibitors/metabolism
;
Mice
;
Rats
;
Receptors, Notch/metabolism
;
Signal Transduction
;
Vascular Neoplasms/*chemically induced
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
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