Publication Date:
1982-04-30
Description:
The nonhallucinogenic ergot derivative lisuride exerts many pharmacological effects that are similar to those of its hallucinogenic congener, lysergic acid diethylamide (LSD). Animals trained to discriminate between the presence of one drug and the other can be used to differentiate the actions of these compounds on a neuronal level. The discriminative stimulus effect of LSD (the LSD cue) is similar to that of the serotonin agonist quipazine, whereas the lisuride cue is similar to that of the dopamine agonist apomorphine. These data support the hypothesis that serotonin is intricately involved in the hallucinogenic effects of LSD.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉White, F J -- Appel, J B -- 9RO1 DA 02543/DA/NIDA NIH HHS/ -- R01 MH 243593/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1982 Apr 30;216(4545):535-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7071600" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Apomorphine/pharmacology
;
Behavior, Animal
;
Biological Assay
;
Ergolines/*pharmacology
;
Lisuride/*pharmacology
;
Lysergic Acid Diethylamide/*pharmacology
;
Male
;
Quipazine/pharmacology
;
Rats
;
Serotonin/physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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