Publication Date:
1996-05-24
Description:
It is widely accepted that tumors are monoclonal in origin, arising from a mutation or series of mutations in a single cell and its descendants. The clonal origin of colonic adenomas and uninvolved intestinal mucosa from an XO/XY mosaic individual with familial adenomatous polyposis (FAP) was examined directly by in situ hybridization with Y chromosome probes. In this patient, the crypts of the small and large intestine were clonal, but at least 76 percent of the microadenomas were polyclonal in origin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Novelli, M R -- Williamson, J A -- Tomlinson, I P -- Elia, G -- Hodgson, S V -- Talbot, I C -- Bodmer, W F -- Wright, N A -- New York, N.Y. -- Science. 1996 May 24;272(5265):1187-90.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cancer Genetics Laboratory, Imperial Cancer Research Fund (ICRF) Laboratories, London, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8638166" target="_blank"〉PubMed〈/a〉
Keywords:
Adenomatous Polyposis Coli/*genetics/pathology
;
Adult
;
Clone Cells
;
Colon/*pathology
;
DNA Probes
;
Genotype
;
Humans
;
Ileum/pathology
;
In Situ Hybridization
;
In Situ Hybridization, Fluorescence
;
Intestinal Mucosa/*pathology
;
Karyotyping
;
Male
;
*Mosaicism
;
Phenotype
;
Y Chromosome
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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