Publication Date:
1983-04-29
Description:
The reticuloendothelial system of mice bearing EMT6 tumors was effectively blocked by intravenous injections of small unilamellar vesicles that incorporated a 6-aminomannose derivative of cholesterol in the lipid bilayer. Neutral liposomes loaded with indium-111-nitrilotriacetic acid were then injected. Fifty percent more radioactivity was deposited in tumors of the animals with blocked reticuloendothelial systems than in controls. Twenty-four hours after the injection of radioactive vesicles, well-defined tumor images were observed in whole-body gamma camera scintigraphs. Biodistribution studies showed that tumors from animals with blocked reticuloendothelial systems had more than twice the radioactivity per gram than any other tissue analyzed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Proffitt, R T -- Williams, L E -- Presant, C A -- Tin, G W -- Uliana, J A -- Gamble, R C -- Baldeschwieler, J D -- GM 21111-09A1/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 29;220(4596):502-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836294" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Indium
;
Liposomes/*administration & dosage
;
Male
;
Mice
;
Mice, Inbred BALB C
;
Mononuclear Phagocyte System/*physiopathology
;
Neoplasm Transplantation
;
Neoplasms/*radionuclide imaging
;
Neoplasms, Experimental/radionuclide imaging
;
Nitrilotriacetic Acid
;
Radioisotopes
;
Radionuclide Imaging/methods
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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