Publication Date:
1995-03-31
Description:
The interleukin-1 beta (IL-1 beta) converting enzyme (ICE) processes the inactive IL-1 beta precursor to the proinflammatory cytokine. Adherent monocytes from mice harboring a disrupted ICE gene (ICE-/-) did not export IL-1 beta or interleukin-1 alpha (IL-1 alpha) after stimulation with lipopolysaccharide. Export of tumor necrosis factor-alpha and interleukin-6 (IL-6) from these cells was also diminished. Thymocytes from ICE-/- mice were sensitive to apoptosis induced by dexamethasone or ionizing radiation, but were resistant to apoptosis induced by Fas antibody. Despite this defect in apoptosis, ICE-/- mice proceed normally through development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kuida, K -- Lippke, J A -- Ku, G -- Harding, M W -- Livingston, D J -- Su, M S -- Flavell, R A -- New York, N.Y. -- Science. 1995 Mar 31;267(5206):2000-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7535475" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
Antibodies, Monoclonal/immunology
;
Antigens, CD95
;
Antigens, Surface/immunology
;
*Apoptosis/drug effects/radiation effects
;
Base Sequence
;
Caspase 1
;
Cells, Cultured
;
Chimera
;
Cysteine Endopeptidases/deficiency/*metabolism
;
Cytokines/*metabolism
;
Dexamethasone/pharmacology
;
Female
;
Interleukin-1/metabolism
;
Lipopolysaccharides/pharmacology
;
Male
;
Mice
;
Mice, Inbred C57BL
;
Molecular Sequence Data
;
Monocytes/*immunology
;
Nigericin/pharmacology
;
T-Lymphocytes/*cytology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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